Endometrial dendritic cell populations during the normal menstrual
... focused on DCs in the decidualized endometrium and their possible role in early spontaneous abortion (Kammerer et al., 2000; Gardner and Moffett, 2003; Askelund et al., 2004). DCs are crucial mediators of the immune response and tolerance, and are likely to be involved in this balance between immune ...
... focused on DCs in the decidualized endometrium and their possible role in early spontaneous abortion (Kammerer et al., 2000; Gardner and Moffett, 2003; Askelund et al., 2004). DCs are crucial mediators of the immune response and tolerance, and are likely to be involved in this balance between immune ...
Immuno-Isolation of Pancreatic Islet Allografts Using Pegylated
... Two major hurdles need to be surmounted for cell therapy for diabetes: (i) allo-immune rejection of grafted pancreatic islets, or stem/precursor cell-derived insulin-secreting cells; and (ii) continuing auto-immunity against the diabetogenic endogenous target antigen. Nanotherapeutics offer a novel ...
... Two major hurdles need to be surmounted for cell therapy for diabetes: (i) allo-immune rejection of grafted pancreatic islets, or stem/precursor cell-derived insulin-secreting cells; and (ii) continuing auto-immunity against the diabetogenic endogenous target antigen. Nanotherapeutics offer a novel ...
Thyroid Function Test Pathway PDF, 77.29 KB
... frequently asked questions on interpreting TFTs. This guidance is to assist GPs in decision making and is not ...
... frequently asked questions on interpreting TFTs. This guidance is to assist GPs in decision making and is not ...
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral
... layer to invade the underlying lymphoid tissue [10]. B lymphocytes and dendritic cells are the initial targets of MMTV infection [11]. These infected antigen-presenting cells (APCs) express virus-encoded superantigen (Sag), a type II transmembrane glycoprotein, at the cell surface in association wit ...
... layer to invade the underlying lymphoid tissue [10]. B lymphocytes and dendritic cells are the initial targets of MMTV infection [11]. These infected antigen-presenting cells (APCs) express virus-encoded superantigen (Sag), a type II transmembrane glycoprotein, at the cell surface in association wit ...
Recognition of LPS by TLR4: potential for anti
... eventually to the activation of the transcription factor nuclear factor-κB (NF-κB), which leads to the production of pro-inflammatory cytokines such as IL-6 and tumor necrosis factor-α (TNF-α)(see Figure 1)(Fitzgerald et al. 2004, Akira et al. 2006, Miller et al. 2005). Sepsis and possible use of st ...
... eventually to the activation of the transcription factor nuclear factor-κB (NF-κB), which leads to the production of pro-inflammatory cytokines such as IL-6 and tumor necrosis factor-α (TNF-α)(see Figure 1)(Fitzgerald et al. 2004, Akira et al. 2006, Miller et al. 2005). Sepsis and possible use of st ...
- Wiley Online Library
... ing.24,25 These observations suggest that inflammation might be driving wound fibrosis. Indeed, mice lacking the family transcription factor PU.1, and thus not able to generate any leucocytic lineages, are nonetheless able to heal wounds effectively as neonates, and do so without subsequent scarring ...
... ing.24,25 These observations suggest that inflammation might be driving wound fibrosis. Indeed, mice lacking the family transcription factor PU.1, and thus not able to generate any leucocytic lineages, are nonetheless able to heal wounds effectively as neonates, and do so without subsequent scarring ...
Preeclampsia and the Systemic Inflammatory Response
... A strong candidate is the soluble receptor for vascular endothelial growth factor also known as soluble fms-like tyrosine kinase (sFlt-1), which is produced by the placenta. By its antiangiogenic actions, an excess of sFlt-1 can cause systemic endothelial damage and dysfunction and hence a systemic ...
... A strong candidate is the soluble receptor for vascular endothelial growth factor also known as soluble fms-like tyrosine kinase (sFlt-1), which is produced by the placenta. By its antiangiogenic actions, an excess of sFlt-1 can cause systemic endothelial damage and dysfunction and hence a systemic ...
Immunological Studies in Malignant Melanoma: Importance of TNF and the Thioredoxin System
... The typical melanoma lesion is relatively easy to identify, even macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the ...
... The typical melanoma lesion is relatively easy to identify, even macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the ...
Endotypes and phenotypes of chronic rhinosinusitis
... demonstrated reduced release of host defense molecules, such as psoriasin/S100A7, and decreased expression of members of the palate, lung, nasal epithelium clone (PLUNC) family of LPS-binding antimicrobial peptides (also called the bacterial permeability–inducing family).29-31 Most of these molecule ...
... demonstrated reduced release of host defense molecules, such as psoriasin/S100A7, and decreased expression of members of the palate, lung, nasal epithelium clone (PLUNC) family of LPS-binding antimicrobial peptides (also called the bacterial permeability–inducing family).29-31 Most of these molecule ...
Characterizing the immune response to HIV-1 using host derived epitope R7V
... 4.6 THE R7V PEPTIDE AS STIMULANT OF IFN-γ PRODUCTION .................. 109 4.7 CONCLUDING DISCUSSION....................................................................... 110 4.7.1 Were R7V antibodies produced during natural HIV-1 subtype C infection and to the same extent as in published literatu ...
... 4.6 THE R7V PEPTIDE AS STIMULANT OF IFN-γ PRODUCTION .................. 109 4.7 CONCLUDING DISCUSSION....................................................................... 110 4.7.1 Were R7V antibodies produced during natural HIV-1 subtype C infection and to the same extent as in published literatu ...
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... Shanna Pace, DVM Practice Limited to Internal Medicine VCA Veterinary Specialty Center of Seattle ...
... Shanna Pace, DVM Practice Limited to Internal Medicine VCA Veterinary Specialty Center of Seattle ...
... (GM-CSF), IL-3 and IL-5) possibly derived from antigen-stimulated T-lymphocytes, mast cells, platelets, or interleukin-1 (IL-1)- and tumour necrosis factor (TNF)stimulated endothelium, 6 , eosinophils may undergo priming and augment the membrane expression of adhesion molecules such as CD 11b, B . A ...
Psoriasis – Pathophysiology, Conventional, and Alternative Approaches to Treatment Review Article
... Review Article Methotrexate (MTX) is the most commonly used systemic agent for psoriasis and, because it has been available for 35 years, most dermatologists are comfortable with its use. Methotrexate inhibits dihydrofolate reductase (resulting in a deficiency of active folic acid) and induces adeno ...
... Review Article Methotrexate (MTX) is the most commonly used systemic agent for psoriasis and, because it has been available for 35 years, most dermatologists are comfortable with its use. Methotrexate inhibits dihydrofolate reductase (resulting in a deficiency of active folic acid) and induces adeno ...
Psoriasis – Pathophysiology, Conventional, and Alternative
... Review Article Methotrexate (MTX) is the most commonly used systemic agent for psoriasis and, because it has been available for 35 years, most dermatologists are comfortable with its use. Methotrexate inhibits dihydrofolate reductase (resulting in a deficiency of active folic acid) and induces adeno ...
... Review Article Methotrexate (MTX) is the most commonly used systemic agent for psoriasis and, because it has been available for 35 years, most dermatologists are comfortable with its use. Methotrexate inhibits dihydrofolate reductase (resulting in a deficiency of active folic acid) and induces adeno ...
Beyond Hemostasis: The Role of Platelets in Inflammation and Infection Archibald McNicol
... thromboxane synthetase for the final synthesis of TxA2. Attenuation of either of these amplification pathways inhibits platelet function and significantly prolongs bleeding in vivo. Therapeutic ADP receptor antagonists, such as clopidogrel, and the cyclooxygenase inhibitor aspirin are effective anti ...
... thromboxane synthetase for the final synthesis of TxA2. Attenuation of either of these amplification pathways inhibits platelet function and significantly prolongs bleeding in vivo. Therapeutic ADP receptor antagonists, such as clopidogrel, and the cyclooxygenase inhibitor aspirin are effective anti ...
Killed but metabolically active microbes: a new vaccine paradigm for
... of infected DC 2.4 cells, a mouse dendritic cell line17, by not shown). In contrast, we detected less than 5% of S-59/UVA wild-type fluorescence microscopy. We measured the frequency of cytosolic Lm or Lm ∆hly (LLO–) in the cytosol (Fig. 1c). L. monocytogenes by colocalization of bacteria with host- ...
... of infected DC 2.4 cells, a mouse dendritic cell line17, by not shown). In contrast, we detected less than 5% of S-59/UVA wild-type fluorescence microscopy. We measured the frequency of cytosolic Lm or Lm ∆hly (LLO–) in the cytosol (Fig. 1c). L. monocytogenes by colocalization of bacteria with host- ...
chapter 16 the adaptive immune response
... Microbiology: A Clinical Approach [9780815365143] © Garland Science ...
... Microbiology: A Clinical Approach [9780815365143] © Garland Science ...
Integrin-associated protein (CD47) and its ligands
... muscle cells11 and platelets12. CD47 is expressed ubiquitously, and, after its cDNA was cloned and expressed, antibodies to CD47 were shown to recognize integrin-associated protein, demonstrating that the two molecules were the same13. Molecular cloning also demonstrated that CD47 was identical to a ...
... muscle cells11 and platelets12. CD47 is expressed ubiquitously, and, after its cDNA was cloned and expressed, antibodies to CD47 were shown to recognize integrin-associated protein, demonstrating that the two molecules were the same13. Molecular cloning also demonstrated that CD47 was identical to a ...
STUDIES ON THE IMMOBILIZATION ANTIGENS OF PARAMECIUM
... was incubated two to three hours at 37"C, and then to each was added two parts of antiserum diluted with buffered saline. The antiserum was 25 times as strong as the greatest dilution giving complete immobilization in one half hour. After five minutes the mixtures were diluted by adding 36 parts of ...
... was incubated two to three hours at 37"C, and then to each was added two parts of antiserum diluted with buffered saline. The antiserum was 25 times as strong as the greatest dilution giving complete immobilization in one half hour. After five minutes the mixtures were diluted by adding 36 parts of ...
Linköping University Post Print Semi Mature Blood Dendritic Cells Exist in
... The connection between these different medical conditions is some degree of chronic inflammation. Patients with PDAC exhibit elevated levels of circulating epithelial growth factor (EGF), IL-6, CXCL8, PGE2, IL-10, and IL-1RA [14,30,31,32]. In accordance to these findings, high levels of several infl ...
... The connection between these different medical conditions is some degree of chronic inflammation. Patients with PDAC exhibit elevated levels of circulating epithelial growth factor (EGF), IL-6, CXCL8, PGE2, IL-10, and IL-1RA [14,30,31,32]. In accordance to these findings, high levels of several infl ...
Plaque reduction test: an alternative method to assess specific
... Phage-displayed peptide systems have been used to identify the immunogenic epitopes and to develop the design of peptidebased or peptide-displaying phages themselves as vaccine candidates. To estimate the humoral immunity of phage-based vaccine, it is necessary to evaluate the antibody response spec ...
... Phage-displayed peptide systems have been used to identify the immunogenic epitopes and to develop the design of peptidebased or peptide-displaying phages themselves as vaccine candidates. To estimate the humoral immunity of phage-based vaccine, it is necessary to evaluate the antibody response spec ...
Hannah Akuffo Publications 1990 to 1999
... Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop Med Hyg. 1994 MayJun;88(3):303-6. 36. Wolday D, Akuffo H, Bri ...
... Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop Med Hyg. 1994 MayJun;88(3):303-6. 36. Wolday D, Akuffo H, Bri ...
Adverse Outcomes in Blood and Blood Component Therapy
... therapy, no transfusion should be given until the decision is made that it is absolutely necessary and even then it must be done with the utmost care. The adverse and at times very severe transfusion reactions experienced by some recipients of blood and blood components therapy, have various causes ...
... therapy, no transfusion should be given until the decision is made that it is absolutely necessary and even then it must be done with the utmost care. The adverse and at times very severe transfusion reactions experienced by some recipients of blood and blood components therapy, have various causes ...