A phase III randomized trial comparing glucocorticoid monotherapy
... on the surface of B-lymphocytes, and it is known that this agent depletes the blood of circulating B-lymphocytes for several months (Roll et al, 2006). Rituximab is licensed for the treatment of malignant B-cell lymphomas and rheumatoid arthritis, but has also been reported to be effective against o ...
... on the surface of B-lymphocytes, and it is known that this agent depletes the blood of circulating B-lymphocytes for several months (Roll et al, 2006). Rituximab is licensed for the treatment of malignant B-cell lymphomas and rheumatoid arthritis, but has also been reported to be effective against o ...
Antiviral applications of Toll-like receptor agonists
... Phase III for the topical treatment of genital herpes before being discontinued due to a lack of adequate efficacy. Resiquimod has also been investigated as an oral treatment of HCV infection in a Phase IIa study in which patients received a 0.01 mg/kg dose of resiquimod twice weekly for 4 weeks.38 ...
... Phase III for the topical treatment of genital herpes before being discontinued due to a lack of adequate efficacy. Resiquimod has also been investigated as an oral treatment of HCV infection in a Phase IIa study in which patients received a 0.01 mg/kg dose of resiquimod twice weekly for 4 weeks.38 ...
Cross-reactivity of anti-human cytokine monoclonal
... sterile permBuffer (Tube 2) or 15 μL whole serum blocking buffer (permBuffer supplemented with 5% mouse/rat serum, both from the animal facility at the Centro de Pesquisas René Rachou, FIOCRUZ-Minas) to monitor nonspecific binding (Tube 3). The cells were incubated in the dark for 30 min at room tem ...
... sterile permBuffer (Tube 2) or 15 μL whole serum blocking buffer (permBuffer supplemented with 5% mouse/rat serum, both from the animal facility at the Centro de Pesquisas René Rachou, FIOCRUZ-Minas) to monitor nonspecific binding (Tube 3). The cells were incubated in the dark for 30 min at room tem ...
Dendritic Cells: Features and Functions
... without added complement. Under the assay conditions we employ. M0 from spleen, peritoneal cavity, thymus, liver and blood show clear-cut Fc mediated binding and uptake. The absence of typical F, receptors on DC has been confirmed using a monoclonal anti-F,. receptor antibody, clone 24G2 (Unkeless 1 ...
... without added complement. Under the assay conditions we employ. M0 from spleen, peritoneal cavity, thymus, liver and blood show clear-cut Fc mediated binding and uptake. The absence of typical F, receptors on DC has been confirmed using a monoclonal anti-F,. receptor antibody, clone 24G2 (Unkeless 1 ...
Pathogen Associated Molecular Patterns, Pattern Recognition Receptors and Pediatric Sepsis Lesley
... lipopolysaccharide (LPS), peptidoglycan (PGN), other cellular components including flagellin, microbial RNA and DNA, viral structures such as envelopes and capsids, as well as many other proteins, glycoproteins and glycolipids. In addition PRRs can respond to some host derived “danger signals” that ...
... lipopolysaccharide (LPS), peptidoglycan (PGN), other cellular components including flagellin, microbial RNA and DNA, viral structures such as envelopes and capsids, as well as many other proteins, glycoproteins and glycolipids. In addition PRRs can respond to some host derived “danger signals” that ...
Macrophage Function During Wallerian Degeneration of Rat Optic
... containing multiple vacuoles and myelin debris and lacking intermediate filaments. The same cell type was labeled by ED1 antibodies. Our results indicate that macrophages remove the vast majority of debris during Wallerian degeneration in the CNS; a proportion of these macrophages concomitantly expr ...
... containing multiple vacuoles and myelin debris and lacking intermediate filaments. The same cell type was labeled by ED1 antibodies. Our results indicate that macrophages remove the vast majority of debris during Wallerian degeneration in the CNS; a proportion of these macrophages concomitantly expr ...
Dectin 1
... 1. Specific delivery of antigens to DCs (e.g. on Ag-covered particles). This approach was proved to work, but remains expensive and difficult. 2. Targeting DEC205, DC-SIGN or mannose receptor by antibodies induces CD4+ and CD8+ cells responses. This can be used to induce tolerance to pancreatic β-ce ...
... 1. Specific delivery of antigens to DCs (e.g. on Ag-covered particles). This approach was proved to work, but remains expensive and difficult. 2. Targeting DEC205, DC-SIGN or mannose receptor by antibodies induces CD4+ and CD8+ cells responses. This can be used to induce tolerance to pancreatic β-ce ...
The role of glucose and lipid metabolism in the
... The cellular growth, function, and survival of activated T cells depend on a dramatic increase in glucose metabolism to provide cellular fuel. This augmented glucose metabolism is highly regulated and has a profound impact on a sustained antiviral response. Thus, impaired glucose metabolism in T cel ...
... The cellular growth, function, and survival of activated T cells depend on a dramatic increase in glucose metabolism to provide cellular fuel. This augmented glucose metabolism is highly regulated and has a profound impact on a sustained antiviral response. Thus, impaired glucose metabolism in T cel ...
Controlling Cytomegalovirus: Helping the Immune System Take the
... Immediate early (IE) proteins are translated within 2 h of infection and do not require the de novo synthesis of viral proteins for their translation [10]. These IE proteins then control subsequently gene expression and virus replication. As such, suppression of IE proteins is thought to contribute ...
... Immediate early (IE) proteins are translated within 2 h of infection and do not require the de novo synthesis of viral proteins for their translation [10]. These IE proteins then control subsequently gene expression and virus replication. As such, suppression of IE proteins is thought to contribute ...
Nature Medicine Essay - The Lasker Foundation
... recognizing and responding to microbial components and other disease-related stimuli. The dendritic-cell lineage of white blood cells controls this intricate system (Fig. 1). After nearly 35 years of research, there are many perspectives from which to appreciate the powerful influence of dendritic c ...
... recognizing and responding to microbial components and other disease-related stimuli. The dendritic-cell lineage of white blood cells controls this intricate system (Fig. 1). After nearly 35 years of research, there are many perspectives from which to appreciate the powerful influence of dendritic c ...
30-01-12 ALLERGY: • GALECTIN-9: A SUPPRESSOR OF FOOD
... BAFF/BLyS: growth factor for B cells after the T-1 stage, essentially in the follicular milieu. BAFF is also required for the differentiation in the spleen of transitional and FO-II cells into MZP B cells and MZ B cells. High levels of BAFF can contribute to autoimmune disease by preventing the tole ...
... BAFF/BLyS: growth factor for B cells after the T-1 stage, essentially in the follicular milieu. BAFF is also required for the differentiation in the spleen of transitional and FO-II cells into MZP B cells and MZ B cells. High levels of BAFF can contribute to autoimmune disease by preventing the tole ...
Evidence for specific immune response against P210 BCR
... colonies in a clonogenic assay.7,8 Residual disease was detected by the latter assay even in patients who had maintained complete remission for up to 3 years.9 How can we thus explain the presence of residual clonogenic Ph-positive cells, which apparently do not repopulate the bone marrow but mainta ...
... colonies in a clonogenic assay.7,8 Residual disease was detected by the latter assay even in patients who had maintained complete remission for up to 3 years.9 How can we thus explain the presence of residual clonogenic Ph-positive cells, which apparently do not repopulate the bone marrow but mainta ...
acALY-18 stimulates release of
... activators. Peripheral blood monocytes – another innate immune cell type – responded poorly to acALY-18. However, monocytes treated with supernatants of acALY-18-activated platelets exhibited increased expression of pro-inflammatory cytokines including IL-6, IL-8 and IL-18. acALY-18 is an exciting n ...
... activators. Peripheral blood monocytes – another innate immune cell type – responded poorly to acALY-18. However, monocytes treated with supernatants of acALY-18-activated platelets exhibited increased expression of pro-inflammatory cytokines including IL-6, IL-8 and IL-18. acALY-18 is an exciting n ...
Regenerating an Immune System: Gene Therapy and Stem Cell
... in the generation of mature B-cells with a high affinity for antigen. The majority of genetically characterized abnormalities that result in a lack of mature B-cells involve defective signaling through the pre-BCR. Of these, approximately 85% of patients that present with early onset recurrent bacte ...
... in the generation of mature B-cells with a high affinity for antigen. The majority of genetically characterized abnormalities that result in a lack of mature B-cells involve defective signaling through the pre-BCR. Of these, approximately 85% of patients that present with early onset recurrent bacte ...
1. What is the lymphatic system and what are its functions? 2. Detail
... A. Diseases-causing agents, also called pathogens, can produce infections within the body. B. The body has two lines of defense against pathogens: nonspecific defenses that guard against any pathogen, and specific defenses (immunity) that mount a response against a very specific target. ...
... A. Diseases-causing agents, also called pathogens, can produce infections within the body. B. The body has two lines of defense against pathogens: nonspecific defenses that guard against any pathogen, and specific defenses (immunity) that mount a response against a very specific target. ...
Effect of Highly Active Antiretroviral Therapy (HAART) on Human
... in the cytokines and other inflammatory markers (IL-6 and C-reactive protein) and other have revealed a decrease in IL-1β, IL-6, IL-12, IFN- γ and TNF- α after 4-6 months of HAART [38,39,40]. In correlation with TCD4+ cells, it was noted that low counts were observed with increased cytokine levels o ...
... in the cytokines and other inflammatory markers (IL-6 and C-reactive protein) and other have revealed a decrease in IL-1β, IL-6, IL-12, IFN- γ and TNF- α after 4-6 months of HAART [38,39,40]. In correlation with TCD4+ cells, it was noted that low counts were observed with increased cytokine levels o ...
Vaccine development strategies Plasmodium falciparum
... as saliva, tears, mucus, and breast milk. IgG constitutes about 80% of the total serum antibodies and are associated with phagocytosis (mainly IgG1 and IgG3), activation of complement system (IgG3 and IgG1, to a smaller extent IgG2), and the release of immune effectors, including highly reactive oxy ...
... as saliva, tears, mucus, and breast milk. IgG constitutes about 80% of the total serum antibodies and are associated with phagocytosis (mainly IgG1 and IgG3), activation of complement system (IgG3 and IgG1, to a smaller extent IgG2), and the release of immune effectors, including highly reactive oxy ...
Butyrophilin and Butyrophilin- like genes and their role in
... the damage they cause, by a variety of effector cells, tissues and molecules that together make up the immune system. The immune system is traditionally classified in two types: innate and adaptive. The innate immune system is the early line of host defense, and consists of biochemical and cellular ...
... the damage they cause, by a variety of effector cells, tissues and molecules that together make up the immune system. The immune system is traditionally classified in two types: innate and adaptive. The innate immune system is the early line of host defense, and consists of biochemical and cellular ...
Mini review Targeting Cancer-Derived Adenosine: New Therapeutic
... practice. Inhibitory immune checkpoint molecules cytotoxic T-like antigen-4 (CTLA4) and programmed death-1 (PD1), expressed on dysfunctional tumor-infiltrating lymphocytes, have been highlighted as targets to reset the effector T-cell immune response. The monotherapies ipilimumab (antiCTLA4) and niv ...
... practice. Inhibitory immune checkpoint molecules cytotoxic T-like antigen-4 (CTLA4) and programmed death-1 (PD1), expressed on dysfunctional tumor-infiltrating lymphocytes, have been highlighted as targets to reset the effector T-cell immune response. The monotherapies ipilimumab (antiCTLA4) and niv ...
Cell proliferation in human epiretinal membranes:
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...