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Immunology
Immunology

... CD4+ (Helper) T Cells: CD4 co-receptor binds APCs class II MHC (self-class II MHC restricted); function to secrete cytokines to modulate immune response  TH1: secrete IL-2 and IFN-γ o T cell proliferation, macrophage activation and Ab production  TH2: secretes IL-4, IL-5 and IL-13 o Eosinophil act ...
, THE GENERATIVE GRAMMAR OF THE IMMUNE SYSTEM
, THE GENERATIVE GRAMMAR OF THE IMMUNE SYSTEM

... so-called receptor molecules on their surface (about 105 identical receptors per B cell), and when such a “resting” B cell is properly stimulated to divide and to mature, its descendants will end up excreting about 2000 antibody molecules per second, all of which are identical, and similar or identi ...
Immunomodulatory Activity of Dalbergia Latifolia on Swis Albino Mice
Immunomodulatory Activity of Dalbergia Latifolia on Swis Albino Mice

... Today’s world is full of stress. Stress, basically is a reaction of mind and body against which have a significant impact on the immune response in general. The immune system is known to be involved in the etiology as well as pathologic mechanisms of many diseases. Immunology is thus probably one of ...
not currently active, names provided by Division Head
not currently active, names provided by Division Head

... which the student is working. At least one of the rotations should be outside of the site at which the student is working. The time allotted to each research rotation has generally been at least 4 full work days over each period, but any arrangement can be made between the individual student and fac ...
Anti-CD43 antibody ab68421 Product datasheet 2 Images Overview
Anti-CD43 antibody ab68421 Product datasheet 2 Images Overview

... physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Sigl ...
Maria Prostova 1
Maria Prostova 1

... therapy)? PVS-RIPO is infused directly into a patients’ tumor (e.g. in the brain). This assures that the maximal amount of virus is delivered directly to the tumor. Once inside the tumor, PVSs-RIPO infects and kills tumor cells. Although this tumor cell killing alone may have tumor-fighting results, ...
Lactic acid bacteria for mucosal vaccines and therapy
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Diapositiva 1
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Hemophagocytic Lymphohistiocytosis (HLH)

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Slides - View the full AIDS 2016 programme
Slides - View the full AIDS 2016 programme

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Biology
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Idiotype builder - Bullet Biotechnology
Idiotype builder - Bullet Biotechnology

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Is atherosclerosis an autoimmune disease? Open Access
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Big, Bigger, Biggest - Yale Peabody Museum of Natural History
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... Create models of a virus, a bacterium and a protozoan to illustrate the size and scale comparison. (Assume that the average protozoan is approximately the same size as a skin cell.) Topics covered include microorganisms, pathogens, characteristics of life, prokaryotes and eukaryotes, the nature of a ...
Monoclonal Antibodies
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... circumvent PCR inhibition or interference with large amounts of contaminating host and commensal DNA from specimens. PCR inhibitors viz. heme molecule, lipopolysaccharides and others are known to affect test sensitivity, in particular those with low target copy numbers. The requirements for subjecti ...
Monoclonal Antibodies
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... of Genetic Information and Protein B. Virus’s Host Range Consists of the Organisms It Infects • Virus can enter only a cell that has a specific receptor on its surface • Virtually all species of animals, fungi, plants, protists, and bacteria get viral infections • Reservoir of a virus is the site wh ...
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Gene therapy for inborn errors of metabolism of the liver

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Immune Mechanisms Are Major Players in Cancer Karl Erik
Immune Mechanisms Are Major Players in Cancer Karl Erik

... Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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