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Slide 1
Slide 1

... • Site of T cell production and maturation • Develops to maximum size during puberty • Gradually atrophies after that • Has two lobes made of lobules • Cortex contains T cells and thymosins • Medulla has capillaries where T cells enter circulation © 2013 Pearson Education, Inc. ...
Marcus A, Raulet DH. 2013. Evidence for natural killer cell memory. Current Biology 23(17):R817-20.
Marcus A, Raulet DH. 2013. Evidence for natural killer cell memory. Current Biology 23(17):R817-20.

... and certain viruses, and mediate enhanced responses to these antigens upon secondary exposure. In infections with mouse cytomegalovirus (MCMV), MCMV-specific NK cells undergo clonal expansion, and display increased effector function after the resolution of the infection. In addition, inflammatory co ...
lymph node - immunology.unideb.hu
lymph node - immunology.unideb.hu

... 1. The central lymphoid organs are not connected to lymphatics – Isolated from the environment 2. The spleen has no lymph circulation – immune response to blood borne antigens 3. HEV – high endothelial venules – special entry sites of blood circulating lymphocytes to peripheral lymphoid organs 4. 1 ...
Elements of Adaptive Immunity
Elements of Adaptive Immunity

... • The Roles of the Major Histocompatibility Complex – Group of antigens first identified in graft patients – Important in determining compatibility of tissues for tissue grafting – Major histocompatibility antigens are glycoproteins found in the membranes of most cells of vertebrate animals – Hold a ...
Poster
Poster

... Role of Thioredoxin In Bacterium Cell Survival ...
the PDF - British Society for Immunology
the PDF - British Society for Immunology

The Immune System
The Immune System

... Disease D. Memory Cells: cells that are made during an immune response but are kept in storage for a future attack by the same QuickTime™ and a decompressor antigen - these cells are needed to see this picture. contain the “recipe” for making a specific type of antibody ...
Sept15_lecture8a_immunology
Sept15_lecture8a_immunology

... diversity which is then fine tuned ...
Older Syllabus - NIMS University Distance Education
Older Syllabus - NIMS University Distance Education

Immunological aspects of liver disease
Immunological aspects of liver disease

... 1969, and providing important critical and enthusiastic support. In 1970, to add basic science depth to the research, Adrian, with the help of an MRC Travelling Fellowship, went to work with Bob Good in Minneapolis, USA, as an immunology research fellow, and was exposed for a year and a half to this ...
"Immune System". - Roitt`s Essential Immunology
"Immune System". - Roitt`s Essential Immunology

... toxins directly, or coat them for recognition by cells with Fc receptors such as phagocytes or NK cells, or trigger complement by classical pathway Any substance that can be recognized by an antigen receptor (an antigen receptor is defined as the product of rearranging genes and expressed only on T a ...
Invest Ophthalmol Vis Sci 1999 - Weizmann Institute of Science
Invest Ophthalmol Vis Sci 1999 - Weizmann Institute of Science

... and may result in visual impairment or even blindness. These types of keratitis occur either as separate disease entities, in association with episcleritis or other ocular disorders, or as a manifestation of a systemic connective tissue disease such as rheumatoid arthritis, Wegener’s granulomatosis, ...
Test one Part one Selection: DIRECTIONS: Each question below
Test one Part one Selection: DIRECTIONS: Each question below

... b. It rarely recurs in a host who has a high antibody titer c. It can be reactivated by emotional disturbances or prolonged exposure to sunlight d. Initial infection usually occurs by intestinal absorption of the virus e. Infection with type 1 virus is most common 4. The latest and most effective th ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
PHS 398 (Rev. 9/04), Biographical Sketch Format Page

... ones. The present proposal addresses the systematic identification and validation of CD4+ T cell epitopes of MTB binding to a panel of HLA class II molecules representative of the most common specificities expressed worldwide. Our proposal is tailored to address important gaps in epitope knowledge t ...
Probing diversity in a hidden world: applications of NGS in
Probing diversity in a hidden world: applications of NGS in

... Three domains of life ...
Structured illumination microscopy reveals novel insights into
Structured illumination microscopy reveals novel insights into

... Cell Biology and Physiology Center, NHLBI, NIH ...
hybridoma technology for production of monoclonal antibodies
hybridoma technology for production of monoclonal antibodies

... Hybridomas are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, Bcells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow ind ...
Trade-offs in antibody repertoires to complex antigens
Trade-offs in antibody repertoires to complex antigens

Meniere`s disease
Meniere`s disease

... • The inner ear has long been considered to be “immunologically privileged” site relatively protected from inflammatory immune events by the blood-labyrinthine barrier • This theory has been challenged by Mogi et al(1982) and Solares et all (2002) • It is believed now that the inner ear is not “immu ...
Follicular Dendritic Cell Sarcoma of Tonsil
Follicular Dendritic Cell Sarcoma of Tonsil

... therefore, essential for correct diagnosis. The extranodal tumours, therefore, can easily be misdiagnosed as FDC markers and are not routinely been used in the immunohistochemical study of poorly differentiated tumours.10 Differential diagnosis is to be made from several tumours, including undiffere ...
Immune defense at the ocular surface
Immune defense at the ocular surface

Module 1 - BluWiki
Module 1 - BluWiki

... Reasons for Emergence and Maintenance of Infectious Diseases o What are some reasons why infectious diseases may emerge?  Zoonosis MAY cross into human population (zoonotic infections are those which can be spread from vertebrate animals to humans)  For example: rabies, salmonella, leishmaniasis  ...
Antibody-Selected Mimics of Hepatitis C Virus Hypervariable Region
Antibody-Selected Mimics of Hepatitis C Virus Hypervariable Region

... protein that presents B and T epitopes shown to induce protective immunity against hepatitis C virus (HCV), might be suitable for this purpose if its immunogenicity can be improved by generating mimics that induce broad, highly cross-reactive, anti-HVR1 responses. Recently we described a successful ...
CARDIOVASCULAR SYSTEM: BLOOD (Chapter 19) Cardiovascular
CARDIOVASCULAR SYSTEM: BLOOD (Chapter 19) Cardiovascular

... Type AB blood = both A + B antigens (4%) Type O blood =neither A nor B antigen (46%) Rh+ = surface antigen D (85%) Rh- = no D antigen (15%) Type A blood = antibodies against B antigen Type B blood = antibodies against A antigen Type AB blood = neither antibody Type O blood = antibodies against both ...
Evaluation of polyomavirus BK cellular immune response by an
Evaluation of polyomavirus BK cellular immune response by an

... viral exposure could represent a potential immunological boost in this context, therefore preventing the subsequent development of virus-related renal damage. In this connection, further studies should be performed on the impact of different immunosuppressive protocols, as suggested by previous stud ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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