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Immunology and Blood Groups
Immunology and Blood Groups

... Natural passive immunity - Antibodies made in one individual are passed into another individual of the same species. This only affords temporary protection, for, as the antibodies do their job, or are broken down by the body's natural processes, their number diminishes and protection is slowly lost. ...
Immunity
Immunity

... primary immune response IgA – dimer that helps prevent attachment of pathogens to epithelial cell surfaces IgG – monomer that is the most abundant and diverse antibody in primary and secondary response; crosses the placenta and confers passive immunity IgE – monomer that binds to mast cells and baso ...
Přednáška 1
Přednáška 1

... Koch and Petri in 1882 - medium in which to grow bacteria no better solidifying agent in microbiological media has been found microbiological, biotechnological, and public health laboratories, and an important colloid in other industries permitted gelling, stabilizing, and thickening agent for food ...
Stomach, Glandular Stomach – Infiltration, Cellular
Stomach, Glandular Stomach – Infiltration, Cellular

... Focal collections of mast cells can occasionally be found in the submucosa of the stomach. Mast cells have been shown to contribute importantly to acute allergic reactions, late-phase reactions, and chronic allergic inflammation. Focal accumulations of mast cells in the submucosa of the gastrointest ...
Immunological Genome Project and systems immunology
Immunological Genome Project and systems immunology

... cell types and the basis for division of labor within a cell system. As examples, cell type-specific function of SMAD3 downstream of transforming growth factor (TGF)b is dictated by lineage-specific master transcription factors (TFs) [4]; and context-dependent functions of interferon-regulatory fact ...
Immunosuppressants: A Review - The Pharma Innovation Journal
Immunosuppressants: A Review - The Pharma Innovation Journal

... differentiated T cells. As such, it is one of the most potent immunosuppressive substances and is clinically used to control the steroid and/or polyclonal antibodies resistant acute rejection episodes. For acting more specifically than polyclonal antibodies, it is also used preventively in transplan ...
P E R S P E C T I V...
P E R S P E C T I V...

... cally and functionally distinct subsets. It is no longer tenable sorting experiments was the isolation of antibody-secreting to study immune-related effects using ‘bulk’ lymphocyte pop- B cells1. Nonetheless, it was quickly appreciated that one fluulations such as ‘memory CD8+ T cells’. Instead, inv ...
Primary antibody deficiency
Primary antibody deficiency

... use of preventative antibiotics. Immunoglobulin therapy is offered to people affected by more severe primary antibody deficiency. Therapeutic immunoglobulin products contain a wide mixture of antibodies that help fight infections. Immunoglobulin is made from screened, donated, blood-derived plasma. ...
BIOGRAPHICAL SKETCH Roland W. Herzog HERZOG
BIOGRAPHICAL SKETCH Roland W. Herzog HERZOG

... This proposal seeks to define the mechanism by which tyrosine mutant AAV capsids direct higher efficiency of gene transfer and potentially circumvent T cell responses against AAV capsid, to develop a baculovirus-based production system for such novel AAV vectors, and to test efficacy in treatment of ...
A role for antigen in the maintenance of immunological memory
A role for antigen in the maintenance of immunological memory

... New memory cells are generated throughout life; however, the memory pool, like all lymphocyte populations, is finite in size9,10. A process of homeostasis must operate to regulate the survival and/or the deletion of memory cells. What happens when new memory cells are generated? Current evidence ind ...
BKLR1
BKLR1

... each time the same antigen symbol appears in the rest of the sequence, even if this antigen symbol does not belong to a binding site. The learning ability is described from the movement to a state, which contains as index the corresponding symbol ri. ...
Modeling and Simulation of the Innate Immune System
Modeling and Simulation of the Innate Immune System

Document
Document

... Thyroid Autoimmunity • Macrophages ingest foreign material and present peptide ...
Carotenoid Action on the Immune Response
Carotenoid Action on the Immune Response

... (12,13). Enhanced NK cell cytotoxicity was observed in human subjects given oral ␤-carotene (14). Similarly, long-term ␤-carotene supplementation to elderly but not middle-age men increased NK cell activity (15). In vitro, ␤-carotene induced hamster macrophages to produce TNF␣ (16). Activation of TN ...
Chap 22
Chap 22

Memory B cells, but not long-lived plasma cells, possess antigen
Memory B cells, but not long-lived plasma cells, possess antigen

Animal models for AIDS
Animal models for AIDS

... Chimpanzee (Pan troglodytes) is the ape that has genetic similarity to human (about 98.5%). Some strains of HIV-1 can infect chimpanzees, thereby establishing an animal model to evaluate vaccines and infection with HIV-1. However, infection with most HIV isolates has not been accompanied by developm ...
Document
Document

... system. Specifically, opioids, including 2-n-pentyloxy-2-phenyl-4-methylmorpholine, naloxone, and beta-endorphin, have been shown to interact with IL-2 receptors and regulate production of IL-1 and IL-2. Conversely, IL-1 has been shown to up-regulate opioid peptide binding in brain tissue.  These r ...
PDF (522KB)
PDF (522KB)

... free mice resistant to experimental allergic diarrhea and the 17 strains have a prophylactic effect in mouse colitis models. The proportion of Clostridia clusters XIVa and IV in ...
Assessment Schedule – 2005 Human Biology: Describe how
Assessment Schedule – 2005 Human Biology: Describe how

Biological Activity of Marine Polysaccharides and Animal Health
Biological Activity of Marine Polysaccharides and Animal Health

... Enhanced expression of maturation markers on the surface of fucoidan-treated DCs (Kim and Joo, 2012) ...
miRNA-124 in Immune System and Immune Disorders
miRNA-124 in Immune System and Immune Disorders

A matter of bacterial life and death
A matter of bacterial life and death

... ‘Resuscitation’, the keystone of the VBNC hypothesis Given that it is conventional microbiological wisdom to equate viability with culturability, it has widely been recognized that confirmation of the VBNC hypothesis would ultimately require recovery of culturable cells from a population of non-cult ...
The Population of CD40L-expressing Cells was Slightly but not
The Population of CD40L-expressing Cells was Slightly but not

... In CIA, blocking B cell activation by treatment with anti-CD40 ligand leads to protection against the disease and a total block of the antibody response.3) Other investigators demonstrated that the administration of stimulatory anti-CD40 mAb resulted in earlier onset and more severe disease using CI ...
Characterization of Bartonella-Bacilliformis Flagella and Effect of
Characterization of Bartonella-Bacilliformis Flagella and Effect of

... carrier states sometimes occur (6). B. bacilliformis is placed in the Rickettsiales family on the basis of its 16S rRNA sequence homology (4, 5), cell size, and route of transmission (4). However, within this family, B. bacilliformis is uniquely motile, possessing 1 to 10 polar flagella 3 to 10 ,um ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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