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Inflammatory Myopathies
Inflammatory Myopathies

... • Aim of the study to determine if these antibodies were predictive of clinical course of ILD in idiopathic inflammatory myositis patients. • Retrospective study of 74 patients who met Peter-Bohan criteria. • The patients with ILD have a worse prognosis than those without. • Anti-ARS are strongly as ...
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European Respiratory Society Annual Congress 2013
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Discrete Gene Loci Regulate Neurodegeneration, Lymphocyte

... crucial mechanisms, especially such that lead to the death of damaged cells and regulate the activation of CNS resident glial cells. The glial cell activation may be important for the interaction with the immune system through the expression of immune-related molecules such as MHC antigens (Kreutzbe ...
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DIET AND THE IMMUNE SYSTEM Professor Parveen Yaqoob 2010
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L1 Nephritis 2013

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Slide 1
Slide 1

... - mechanisms of recognition of “danger” signal - mechanisms of activation and regulation of defense - effector mechanisms of destruction and elimination of pathogens and neutralization of their harmful products ...
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Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Prominent examples include Celiac disease, diabetes mellitus type 1, Sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, Churg-Strauss Syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's Disease, rheumatoid arthritis (RA), Polymyositis (PM), and Dermatomyositis (DM). Autoimmune diseases are very often treated with steroids.The misconception that an individual's immune system is totally incapable of recognizing self antigens is not new. Paul Ehrlich, at the beginning of the twentieth century, proposed the concept of horror autotoxicus, wherein a ""normal"" body does not mount an immune response against its own tissues. Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. Now, it is accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed ""natural autoimmunity""), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. Autoimmunity should not be confused with alloimmunity.
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