msb20105-sup-0002 - Molecular Systems Biology
... As in our previous model (Proctor & Gray, 2008), we assume that DNA damage activates ATM which then phosphorylates both p53 and Mdm2 to interrupt their binding. This leads to stabilisation of p53. Since p53 is a transcription factor for Mdm2, there is also an increase in Mdm2 levels, which then bind ...
... As in our previous model (Proctor & Gray, 2008), we assume that DNA damage activates ATM which then phosphorylates both p53 and Mdm2 to interrupt their binding. This leads to stabilisation of p53. Since p53 is a transcription factor for Mdm2, there is also an increase in Mdm2 levels, which then bind ...
Mitochondrial Genome, Role of Mitochondria in Cell Metabolism
... • Usually heteroplasmy • Symptoms depend on distribution of mutated mtDNA and energy requirements of particular tissues - clinical phenotype ...
... • Usually heteroplasmy • Symptoms depend on distribution of mutated mtDNA and energy requirements of particular tissues - clinical phenotype ...
Lh6Ch19bEtrans
... EOC Problem 17 Gets into the rate of ATP turnover in heart muscle…the muscle that always has to be “on”. EOC Problem 18 Gets into the same in insect flight muscle. ...
... EOC Problem 17 Gets into the rate of ATP turnover in heart muscle…the muscle that always has to be “on”. EOC Problem 18 Gets into the same in insect flight muscle. ...
10 - LifeSciTRC
... 1. Increase in ROS (Reactive Oxygen Species) 2. NADPH, Xanthine Oxidase, Complex I & III 3. Inhibition of Ox-Phos allows ubiquinone to form ubisemiubiquinone. ...
... 1. Increase in ROS (Reactive Oxygen Species) 2. NADPH, Xanthine Oxidase, Complex I & III 3. Inhibition of Ox-Phos allows ubiquinone to form ubisemiubiquinone. ...
Supplementary Methods
... (LKB Wallac; Turku, Finland). All data are representative experiments of at least three independent repetitions and are shown as mean ± standard error. Oxidative stress measurements: Dichlorofluorescein (DCF) Fluorescence - 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl es ...
... (LKB Wallac; Turku, Finland). All data are representative experiments of at least three independent repetitions and are shown as mean ± standard error. Oxidative stress measurements: Dichlorofluorescein (DCF) Fluorescence - 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl es ...
word
... Pyruvate as critical point – availability of oxygen determine next steps; lactic acidosis Shuttle for NADH into mitochondrion Glycolysis generates precursors for other paths Ch 23 oxidation of fatty acids, ketones Oxidation of long-chain fatty acids (LCFA) – from absorption or degradation from adipo ...
... Pyruvate as critical point – availability of oxygen determine next steps; lactic acidosis Shuttle for NADH into mitochondrion Glycolysis generates precursors for other paths Ch 23 oxidation of fatty acids, ketones Oxidation of long-chain fatty acids (LCFA) – from absorption or degradation from adipo ...
Role of IDH2 in the brown adipose tissue Abstract
... though IDH2 is involved in intermediary metabolism and decrease of reactive oxygen species (ROS), there is currently a limited understanding of how IDH2 ameliorates ROS-based obesity at the molecular level. Here, we describe the function of IDH2 in high fat diet-induced obesity. IDH2 knockout (KO) m ...
... though IDH2 is involved in intermediary metabolism and decrease of reactive oxygen species (ROS), there is currently a limited understanding of how IDH2 ameliorates ROS-based obesity at the molecular level. Here, we describe the function of IDH2 in high fat diet-induced obesity. IDH2 knockout (KO) m ...
Slide 1
... oxygen forming to small end products such as CO2, H2O and NH3 to yield energy. These processes are oxidative (meaning substrates are loosing electrons) and exergonic (energy releasing). In order to capture the energy from these compounds, the oxidation reactions must be coupled with reactions that c ...
... oxygen forming to small end products such as CO2, H2O and NH3 to yield energy. These processes are oxidative (meaning substrates are loosing electrons) and exergonic (energy releasing). In order to capture the energy from these compounds, the oxidation reactions must be coupled with reactions that c ...
Mechanisms
... Reactions with target molecules Cellular deregulation Repair mechanisms “Essentials of Toxicology” by Klaassen Curtis D. and Watkins John B ...
... Reactions with target molecules Cellular deregulation Repair mechanisms “Essentials of Toxicology” by Klaassen Curtis D. and Watkins John B ...
Preface
... Molecular oxidation affects cell function and can lead to cell degeneration or cell death. Free radicals are a major factor in inducing this oxidation and they can attack and inactivate or alter the biological activity of molecules such as lipids and proteins that are essential for cell function. If ...
... Molecular oxidation affects cell function and can lead to cell degeneration or cell death. Free radicals are a major factor in inducing this oxidation and they can attack and inactivate or alter the biological activity of molecules such as lipids and proteins that are essential for cell function. If ...
Mechanisms of Ischemic Brain Damage
... So, when calcium concentration is transient,particularly when Ca+2 is excessive and sustained, membrane function and metabolic activities alteration can cause harmful effects. ...
... So, when calcium concentration is transient,particularly when Ca+2 is excessive and sustained, membrane function and metabolic activities alteration can cause harmful effects. ...
oxidation, reduction, redox potential, citric acid cycle, respiratory
... radicals, hydrogen peroxide (H2O2), hydroxyl radical OH. and superoxide O2-. Reactive nitrogen species (RNS) have similar characteristic and function as ROS. The main source of ROS under physiological conditions is respiratory chain. ROS are products of imperfect oxygen reduction. Fenton reaction is ...
... radicals, hydrogen peroxide (H2O2), hydroxyl radical OH. and superoxide O2-. Reactive nitrogen species (RNS) have similar characteristic and function as ROS. The main source of ROS under physiological conditions is respiratory chain. ROS are products of imperfect oxygen reduction. Fenton reaction is ...
Mitochondrial Function, Cellular Energy Flux and Hypoxia Analysis
... Isolated mitochondria and permeabilised cells ...
... Isolated mitochondria and permeabilised cells ...
No Slide Title
... the common pathway of apoptosis. Upon PT, apoptogenic factors leak into the cytoplasm from the mitochondrial intermembrane space. Two such factors, cytochrome c and apoptosis inducing factor (AIF), begin a cascade of proteolytic activity that ultimately leads to nuclear damage (DNA fragmentation, DN ...
... the common pathway of apoptosis. Upon PT, apoptogenic factors leak into the cytoplasm from the mitochondrial intermembrane space. Two such factors, cytochrome c and apoptosis inducing factor (AIF), begin a cascade of proteolytic activity that ultimately leads to nuclear damage (DNA fragmentation, DN ...
Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. Examples include peroxides. superoxide, hydroxyl radical, and singlet oxygen.ROS are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically. This may result in significant damage to cell structures. Cumulatively, this is known as oxidative stress. ROS are also generated by exogenous sources such as ionizing radiation.