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The polyvagal theory: phylogenetic substrates of
The polyvagal theory: phylogenetic substrates of

... brain is processing emotional stimuli. Usually, the emotional states were associated with fight!flight behaviors and the sympathetic-adrenal system Že.g. increases in heart rate, sweat gland activity, and circulating catecholamines . as described by Cannon Ž1928.. The current emphasis on cortisol as ...
The polyvagal theory: phylogenetic substrates of a
The polyvagal theory: phylogenetic substrates of a

... brain is processing emotional stimuli. Usually, the emotional states were associated with fight᎐flight behaviors and the sympathetic-adrenal system Že.g. increases in heart rate, sweat gland activity, and circulating catecholamines . as described by Cannon Ž1928.. The current emphasis on cortisol as ...
Oxidative stress-driven parvalbumin interneuron impairment as a
Oxidative stress-driven parvalbumin interneuron impairment as a

... Figure 1. Relationship between oxidative stress and PVI integrity in the ACC of 2–3 month-old animal models relevant to schizophrenia, autism and/or redox dysregulation. (a) Oxidative stress (assessed by the immunoreactivity intensity against 8-oxo-2'-deoxyguanosine (8-oxodG), a marker of mitochondr ...
Disruption of the Blood-Brain Barrier and Neuronal Cell Death in
Disruption of the Blood-Brain Barrier and Neuronal Cell Death in

... We investigated the effects of a combined exposure to restraint stress and low doses of chemicals pyridostigmine bromide (PB), N, N-diethyl-m-toluamide (DEET), and permethrin in adult male rats, a model of Gulf-War syndrome. Animals were exposed daily to one of the following for 28 days: (i) a combi ...
Advances in Heart Failure - Circulation: Heart Failure
Advances in Heart Failure - Circulation: Heart Failure

... interleukin-6 (IL-6). Progressive increases in IL-6 concentrations were seen in all patients over time, but the rate of increase was significantly higher in members of the care giver cohort, who were under increased stress.76 Similar increases in IL-6 were seen in other stress states such as marital ...
Psychosocial Stress in Rats: Animal Model of PTSD Based on
Psychosocial Stress in Rats: Animal Model of PTSD Based on

... individuals also develop an array of other debilitating symptoms, including persistent anxiety, an exaggerated startle response, cognitive impairments, and an impaired ability to extinguish conditioned fear (Stam 2007). Trauma exposure is a necessary, but not sufficient, component of PTSD development ...
E ffects of different kinds of acute stress on nerve growth factor
E ffects of different kinds of acute stress on nerve growth factor

... One possible explanation for this finding is that glucocorticoids, which are elevated during stress, reduce NGF synthesis [5,40]. However, contrary to this hypothesis, the change of glucocorticoid concentration during stress experiments does not always correspond to the reduction of measured NGF con ...
IN VIVO Research Article  SHIVAPRIYA SHIVAKUMAR
IN VIVO Research Article SHIVAPRIYA SHIVAKUMAR

... cognitive decline. In the present study the level of acetylcholine and ChAT activity is found to decrease in the aged brain also support significant relationship between ageing, cholinergic impairment and cognitive decline. The test drug increases the acetylcholine and ChAT activity by stimulating t ...
Co-Occurring Mental and Substance Use Disorders
Co-Occurring Mental and Substance Use Disorders

... heroin-dependent individuals with and without depression have also been reported (35). Blunted peripheral stress hormone responses may be a marker for increased HPA axis activity (36, 37). Evidence of altered neuroendocrine response to stress challenges in substance use disorders is consistent with ...
Humor an Antidote for Stress
Humor an Antidote for Stress

... and tear within the body" as it adapts to change or threat. (6) Chronic exposure to job stress can lead to burnout which Christine Maslach defines as "a syndrome of emotional exhaustion and cynicism that occurs frequently among individuals who do 'people work' of some kind". (1) Nurses are compassio ...
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive

... Keywords: Ascorbic acid Antioxidant Depression Chronic unpredictable stress Oxidative stress ...
Stress and Glucocorticoids Affect the Expression of Brain
Stress and Glucocorticoids Affect the Expression of Brain

... Because neurotrophic factors are necessary for the normal development, survival, and plasticity of neurons, we reasoned that they too might be relevant to the neuropathological effects of chronic stress. In addition to NGF, several related neurotrophic factors have been recently characterized includ ...
Autonomic Nervous System IV
Autonomic Nervous System IV

... • Reflex regulation of the GI tract (CNS & LOCAL) ...
Nursing Burnout Paper
Nursing Burnout Paper

... Spence Laschinger et. al, 2009). When a negative working environment exists, nurses may have negative feelings towards their profession or place of employment causing low quality patient care. Moreover, effects of low staffing may increase workload; therefore, the stress experienced by nurses is als ...
Control of dopaminergic neuron survival by the unfolded protein
Control of dopaminergic neuron survival by the unfolded protein

... a control, we determined the efficiency of the neurotoxin-induced lesion by measuring the extent of striatal denervation triggered by 6OHDA (Fig. 1C and Fig. S1C). XBP1 Deficiency Triggers Spontaneous ER Stress in the SNpc. XBP1 is crucial to the function of professional secretory cells, and its def ...
Chronic stress prior to hippocampal stroke
Chronic stress prior to hippocampal stroke

... profiles of stress and CORT-related changes, but also highlight the central role of psychological conditions (e.g., emotional disturbances) in the development of the brain structure and function. Because little is known about the contribution of CORT in stress-dependent challenges before the ischemic ...
How the Brain Makes Play Fun
How the Brain Makes Play Fun

... both group-housed and socially isolated rats developed social conditioned place preference of comparable magnitudes, despite the fact that the isolated animals played more during conditioning. Conditioned place preference did not develop in group-housed rats that were conditioned with an isolated pa ...
Impact of early-life stress on the medial prefrontal cortex functions
Impact of early-life stress on the medial prefrontal cortex functions

... Although anxiety and mood disorders (MDs) are the most common mental diseases, the etiologies and mechanisms of these psychopathologies are still a matter of debate. The medial prefrontal cortex (mPFC) is a brain structure that is strongly implicated in the pathophysiology of these disorders. A grow ...
White Paper Changing people`s habits is associated with reductions
White Paper Changing people`s habits is associated with reductions

A Brief Overview of Molecular Mechanisms of Depression and its
A Brief Overview of Molecular Mechanisms of Depression and its

... The most prominent SNP site associated with the therapeutic response to selective serotonin reuptake inhibitors (SSRIs) in MDD patients occurs in the transcriptional control ...
S - 7473-2390-3942 Accountability in United States
S - 7473-2390-3942 Accountability in United States

... with neuronal development coupled with relatively small hippocampus size to the detriment of the fetus. The hippocampus is an organ in the brain responsible for numerous functions, among them memory and navigation (Mandal, 2015). Any interference with hippocampus development results into severe memo ...
pre_print_Blunted_and_exaggerated_cardiac_stress_reactivity
pre_print_Blunted_and_exaggerated_cardiac_stress_reactivity

... engagement, stressfulness, or difficulty. This study supports the notion that blunted peripheral physiological stress reactivity may be a marker of some form of biological disengagement in brain areas supporting motivated behaviour. ...
Progress and Controversy in the Study of Posttraumatic Stress
Progress and Controversy in the Study of Posttraumatic Stress

... its biological basis, it does not capture this uniquely human aspect of trauma. ...
Neurology and Trauma: Impact and Implications
Neurology and Trauma: Impact and Implications

... flashbacks, nightmares, and physiological responses similar to when the traumatic event was occurring (racing heart, dizziness, sweating, erratic breathing); b) avoidance and numbing such as avoiding situations and people that remind them of the trauma, amnesia for trauma related information, loss o ...
Neurotransmitters Role in Health 2008 PPT
Neurotransmitters Role in Health 2008 PPT

... 3. Differentiate inhibitory and excitatory neurotransmitters 4. Describe the importance of neurotransmitter homeostasis in health 5. Identify stressors that affect neurotransmitter levels 6. State the methods used to measure neurotransmitter levels 7. Specify the correlation between urinary neurotra ...
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Social stress

Social stress is stress that stems from one's relationships with others and from the social environment in general. A person experiences stress when he or she does not have the ability or resources to cope when confronted with an external stimulus (stressor), or when they fear they do not have the ability or resources. An event which exceeds the ability to cope does not necessarily have to occur in order for one to experience stress, as the threat of such an event occurring can be sufficient. This can lead to emotional, behavioral, and physiological changes that can put one under greater risk for developing a mental disorder and physical illness.Humans are social beings by nature, as they typically have a fundamental need and desire to maintain positive social relationships. Thus, they usually find maintaining positive social ties to be beneficial. Social relationships can offer nurturance, foster feelings of social inclusion, and lead to reproductive success. Anything that disrupts or threatens to disrupt their relationships with others can result in social stress. This can include low social status in society or in particular groups, giving a speech, interviewing with potential employers, caring for a child or spouse with a chronic illness, meeting new people at a party, the threat of or actual death of a loved one, divorce, and discrimination. Social stress can arise from one's micro-environment (e.g., family ties) and macro-environment (e.g., hierarchical societal structure). Social stress is typically the most frequent type of stressor that people experience in their daily lives and affects people more intensely than other types of stressors.
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