Gene expression analysis
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
Rapid Diversification of RNase A Superfamily Ribonucleases from
... ribonuclease genes both within and between subclusters A and B (Fig. 2B). The ratio of nonsynonymous to synonymous substitutions between subclusters was unremarkable, with all values falling well below 1.0, and an average dN/dS of 0.63 ± 0.08 for the 35 pairs evaluated. In contrast, the values for d ...
... ribonuclease genes both within and between subclusters A and B (Fig. 2B). The ratio of nonsynonymous to synonymous substitutions between subclusters was unremarkable, with all values falling well below 1.0, and an average dN/dS of 0.63 ± 0.08 for the 35 pairs evaluated. In contrast, the values for d ...
documentation in PDF format
... Restrict results - for many variants the VEP will report multiple consequence types - typically this is because the variant overlaps more than one transcript. For each of these options the VEP uses consequence ranks that are subjectively determined by Ensembl. This table gives all of the consquence ...
... Restrict results - for many variants the VEP will report multiple consequence types - typically this is because the variant overlaps more than one transcript. For each of these options the VEP uses consequence ranks that are subjectively determined by Ensembl. This table gives all of the consquence ...
Document
... Insight into Human Genetic Disorder • Waardenburg’s syndrome is characterized by pigmentary dysphasia • Gene implicated in the disease was linked to human chromosome 2 but it was not clear where exactly it is located on chromosome 2 ...
... Insight into Human Genetic Disorder • Waardenburg’s syndrome is characterized by pigmentary dysphasia • Gene implicated in the disease was linked to human chromosome 2 but it was not clear where exactly it is located on chromosome 2 ...
Alarmingly High Segregation Frequencies of Quinolone Resistance
... TRAs to each of the three antibiotic classes are summarized in table 1. As can be seen, many of these TRAs are known to confer resistance across highly diverse bacterial phyla. In many metagenomic studies, large assemblages of bacteria are sequenced directly from their natural environments. In such ...
... TRAs to each of the three antibiotic classes are summarized in table 1. As can be seen, many of these TRAs are known to confer resistance across highly diverse bacterial phyla. In many metagenomic studies, large assemblages of bacteria are sequenced directly from their natural environments. In such ...
Male-killing i n two species of insect Wolbachia 1~ THE ROYAL
... filarial nematodes, where it is thought to be a beneficial symbiont (Bandi et al. 1998). The frequent incidence of Wolbachia ( Werren et al. 1995x), and their ability to manipulate host reproduction, have led to their being proposed as important agents in the evolution of arthropod hosts (Werren 199 ...
... filarial nematodes, where it is thought to be a beneficial symbiont (Bandi et al. 1998). The frequent incidence of Wolbachia ( Werren et al. 1995x), and their ability to manipulate host reproduction, have led to their being proposed as important agents in the evolution of arthropod hosts (Werren 199 ...
C 2: A A -
... SHV types. Indeed, several oxacillinases (OXA-2 and OXA-10 derivatives, and OXA18) have been reported in P. aeruginosa that have extended substrate profiles including extended-spectrum cephalosporins (7, 40, 45). Thirdly, expression of the chromosomeencoded cephalosporinase of P. aeruginosa may be u ...
... SHV types. Indeed, several oxacillinases (OXA-2 and OXA-10 derivatives, and OXA18) have been reported in P. aeruginosa that have extended substrate profiles including extended-spectrum cephalosporins (7, 40, 45). Thirdly, expression of the chromosomeencoded cephalosporinase of P. aeruginosa may be u ...
Genome Biology - Department of Computer Science and
... recruit chromatin modification enzymes to induce chromatin structure changes, which in turn affect the accessibility of factors to genomic DNA regions [3, 4]. The target genes of a TF change according to developmental, physiological and extra-cellular environmental conditions [5]. In addition, TFs i ...
... recruit chromatin modification enzymes to induce chromatin structure changes, which in turn affect the accessibility of factors to genomic DNA regions [3, 4]. The target genes of a TF change according to developmental, physiological and extra-cellular environmental conditions [5]. In addition, TFs i ...
The Complex Inheritance of Maize Domestication Traits and Gene
... Candidate genes enriched in various functional categories . . . . . . 86 ...
... Candidate genes enriched in various functional categories . . . . . . 86 ...
SNP Discovery and Genotyping Workshop (PowerPoint)
... Warfarin Pharmacogenetics 1. Background • Warfarin characteristics • Pharmacokinetics/Pharmacodynamics • Discovery of VKORC1 2. VKORC1 - SNP Discovery 3. VKORC1 - SNP Selection (tagSNPs) 4. VKORC1 - SNP Testing • SNP/Haplotype Inference • Haplotype Inference, Testing 5. VKORC1 - SNP Replication/Fun ...
... Warfarin Pharmacogenetics 1. Background • Warfarin characteristics • Pharmacokinetics/Pharmacodynamics • Discovery of VKORC1 2. VKORC1 - SNP Discovery 3. VKORC1 - SNP Selection (tagSNPs) 4. VKORC1 - SNP Testing • SNP/Haplotype Inference • Haplotype Inference, Testing 5. VKORC1 - SNP Replication/Fun ...
... favorable genes is “the generally accepted” explanation of hybrid vigor. Such a statement seems to imply that the heterosis problem has been completely solved and requires no further investigation. To point the fallacy of such a conclusion I call attention to an important paper by EAST,published in ...
1 FRQ-interacting RNA Helicase (FRH) Mediates Negative and
... loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et al. 2003), and this negative feedback gives rise to rhythmic expression of frq and other ccg ...
... loop (Crosthwaite et al. 1997). Later work established that FRQ actually binds to and inhibits the activity of its own transcription activators, the WCC (Cheng et al. 2001a; Denault et al. 2001; Froehlich et al. 2003), and this negative feedback gives rise to rhythmic expression of frq and other ccg ...
Comparative gene mapping in Arabidopsis lyrata chromosomes 6
... the formation of the A. thaliana chromosomes. Like A. thaliana chromosome I, chromosome IV evolved from two A. lyrata chromosomes, but, rather than a fusion, there was a reciprocal translocation between AL6 and AL7, with the loss of an NOR probably present on A. lyrata chromosome 7 (Lysak et al., 20 ...
... the formation of the A. thaliana chromosomes. Like A. thaliana chromosome I, chromosome IV evolved from two A. lyrata chromosomes, but, rather than a fusion, there was a reciprocal translocation between AL6 and AL7, with the loss of an NOR probably present on A. lyrata chromosome 7 (Lysak et al., 20 ...
Genome-Wide Association Mapping Reveals Novel QTL for
... made it feasible to genotype a large collection of germplasm lines with thousands of SNP markers. As a result, the GWAS approach, based on the principle of linkage disequilibrium (LD), has been effectively used to exploit existing allelic diversity for traits of agronomic importance. Compared with b ...
... made it feasible to genotype a large collection of germplasm lines with thousands of SNP markers. As a result, the GWAS approach, based on the principle of linkage disequilibrium (LD), has been effectively used to exploit existing allelic diversity for traits of agronomic importance. Compared with b ...
Comparison of different PCR tests for detecting Shiga toxin
... and Paton, 1998). These tests are suited to the identification of isolated strains of bacteria and have been shown to be specific and sensitive for the examination of complex matrices such as foods and stools (Sharma and Dean-Nystrom, 2003). However, in a mixture of bacteria, the genetic profile obt ...
... and Paton, 1998). These tests are suited to the identification of isolated strains of bacteria and have been shown to be specific and sensitive for the examination of complex matrices such as foods and stools (Sharma and Dean-Nystrom, 2003). However, in a mixture of bacteria, the genetic profile obt ...
Deciphering the Galaxy Guppy phenotype
... assigned to various strains. If I am not mistaken, he thought there was a single platinum gene found in many modern guppy strains, including the Galaxy, Medusa and such broad types as the Full Gold guppies, Santa Marias and so on. But in attempting to reproduce his strain I discovered that there are ...
... assigned to various strains. If I am not mistaken, he thought there was a single platinum gene found in many modern guppy strains, including the Galaxy, Medusa and such broad types as the Full Gold guppies, Santa Marias and so on. But in attempting to reproduce his strain I discovered that there are ...