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Finding orthologous groups
Finding orthologous groups

... Genes are homologous if and only if they derive from the same ancestral gene • Sufficient sequence similarity proofs homology • Very dissimilar sequences: PSI blast, HMM searches ...
Epigenomics Workshop - Institute for Systems Genomics
Epigenomics Workshop - Institute for Systems Genomics

How to find genes whose expression profile is similar
How to find genes whose expression profile is similar

... You need to specify either the index position of the genes you want (which row of the expression array the gene is in) or the name (consistent with the featureNames of the ExpressionSet). A vector of names can be specified and matches for all will be computed. The number of matches and the distance ...
Mendelian Genetics and Extensions to Mendelism
Mendelian Genetics and Extensions to Mendelism

Human Genome
Human Genome

... 2. Pour the pea mixture through a strainer into another container. Add about 2 tablespoons of liquid detergent to the mixture. Let it sit for 5 to 10 minutes. 3. Pour the mixture into three test tubes or smaller containers so that each is one-third full. Then add a pinch of meat tenderizer to each c ...
Branchiootorenal (BOR/BOS) Spectrum Disorder Panel
Branchiootorenal (BOR/BOS) Spectrum Disorder Panel

Inheritance - Glen Rose FFA
Inheritance - Glen Rose FFA

... Inheritance: the way genes are passed down. • If a father doesn’t have a leg does that mean his children will be born with out a leg???? ...
X-linked Inheritance - Great Ormond Street Hospital
X-linked Inheritance - Great Ormond Street Hospital

... Genes are instructions that control the way that we grow and develop. We have many thousands of genes and have two copies of nearly every gene. Normally we inherit one copy from each parent and pass one copy onto each child. We all have several genes that have a misprint in them, but usually these a ...
Presentation - Broad Institute
Presentation - Broad Institute

... The Contribution of Ploidy to Evolutionary Divergence of Gene Expression in Yeasts Eric Delgado Regev Group Summer Research Program in Genomics ...
Slide 1
Slide 1

... Every time the sequence data for a particular record is changed, its version number increases and it receives a new GI. However, while each new version number is based upon the previous version number, a new GI for an altered sequence may be completely different from the previous GI. For example, in ...
Genética Molecular em Medicina Transfusional
Genética Molecular em Medicina Transfusional

... sequenced. If enough fragments are sequenced, it will be possible to reconstruct the BAC based on overlapping fragments. ...
LB 144: Organismal Biology
LB 144: Organismal Biology

... held  together   during  synapsis   ...
Chapter 14 * The Human Genome
Chapter 14 * The Human Genome

... A human diploid cell contains 46 chromosomes Chromosomes 21 and 22 are the smallest human autosomes  they were the first two chromosomes to be sequenced and their structural features are representative of other chromosomes On both chromosomes there are long stretches of DNA that do not code for g ...
Additional Glossary and Concepts List for Vertebrate Genetics
Additional Glossary and Concepts List for Vertebrate Genetics

A History of Genetics and Genomics
A History of Genetics and Genomics

... The information age is essential to genomics. The electronic analysis, distribution and storage of genomic data is a hallmark of the science. Critical to this was the development of computers, both large and small, which put computing power in the hands of all scientists. The free distribution of an ...
linkage
linkage

...  So far the crosses we have learnt about ...
Multiple Sclerosis Basic Facts Series
Multiple Sclerosis Basic Facts Series

... areas throughout the human genome. When one of them is identified as being consistently inherited by people with MS, the scientists focus on that area, seeking additional markers that may be closer to the actual gene. Eventually the absolute location of a gene can be identified. This process of movi ...
Learning objectives: • Define the terms `Gene` and `Chromosome
Learning objectives: • Define the terms `Gene` and `Chromosome

lecture 5
lecture 5

... » Expressivity may vary with number of loci – Many other factors complicate analysis » Some mutant genes may have large effect » Mutations at some loci may be recessive while others are dominant or codominant ...
A History of Genetics and Genomics
A History of Genetics and Genomics

Presentation Tuesday
Presentation Tuesday

... Orthologs are expected to have relatively high levels of sequence identity to each other (compared to to other non-orthologous homologs), because they diverged relatively recently, and …… because they have similar functions…. (???) Large scale orthology determination is often done using bidirectiona ...
Chromosomal Mapping of Murine c-fes and c
Chromosomal Mapping of Murine c-fes and c

... Polymorphism within the murine c-fes locus was detected by Southern blotting of restriction endonuclease-digested DNA of the two progenitor strains A and B, followed by hybridization with a c-fes probe (7). The pattern obtained by using DNA digested with four different restriction enzymes suggests t ...
paper by Acquisti, Elser and Kumar
paper by Acquisti, Elser and Kumar

... 2007; Bragg et al. 2006; Bragg & Hyder 2004; Kolkman et al. 2006; McEwan et al. 1998). In the future, availability of completely sequenced and better annotated plant genomes (including those that are undomesticated, symbiotic with N-fixing bacteria, and crop species) will permit further quantificati ...
Integrons: natural tools for bacterial genome evolution
Integrons: natural tools for bacterial genome evolution

Heredity Lecture -Epistasis, Polygenic and Sex
Heredity Lecture -Epistasis, Polygenic and Sex

... Epistasis: "To Stand Upon" - An Override Gene ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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