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Exome Sequencing Project release
Exome Sequencing Project release

... for unambiguous genetic links to disease by focusing attention on the protein coding portion of the genome In the journal Science**, Dr. Leal and her colleagues wrote that GWAS have substantially improved knowledge about common genetic variation, but have been generally uninformative about the patte ...
Identifying Chromosomal Abnormalities Using Infinium
Identifying Chromosomal Abnormalities Using Infinium

... Copy-neutral loss of heterozygosity (or “acquired uniparental disomy”) – Case in which one allele of a gene in a heterozygote is already inactivated and the second, “good” allele is lost without a net change in copy number. This can occur through a gene conversion event in which the chromosome regio ...
Scanning Life`s Matrix: Genes, Proteins, and Small Molecules (2002
Scanning Life`s Matrix: Genes, Proteins, and Small Molecules (2002

... today. What I'd like to do in today's lecture is talk about the Human Genome Project and about what we learn by studying genomes. See, I'm a geneticist, and as a geneticist, what I do is...I study variation. I'm really interested-- all geneticists are really interested--in variation. And this pictur ...
Gene Mapping using 3 Point Test Crosses: Outlined below are the
Gene Mapping using 3 Point Test Crosses: Outlined below are the

... genotypes, we use that information along with the information obtained from the doublecrossover. The double-crossover gametes are always in the lowest frequency. From the table the ABc and abC genotypes are in the lowest frequency. The next important point is that a double-crossover event moves the ...
Gene Ontology
Gene Ontology

... Current  status  of  Gene  Ontology ...
Analysis of mutant strains
Analysis of mutant strains

... will be looking for correct usage in your reports! Pay close attention to italics and capital letters. Gene names are placed in italics, while proteins and phenotypes are referred to with normal font. Gene names that begin with capital letters refer to dominant alleles, while gene names beginning wi ...
The Chromosomal Basis of Inheritance
The Chromosomal Basis of Inheritance

... A-B-C-D-E-F-G-H-I-J & M-N-O-P-Q-R-S-T deletion inversion translocation What chromosome alterations have occurred if daughter cells have a gene sequence of A-B-C-O-P-Q-G-J-I-H on the first chromosome? ...
DOCX format - 64 KB - Office of the Gene Technology Regulator
DOCX format - 64 KB - Office of the Gene Technology Regulator

... The risk assessment concludes that risks to the health and safety of people, or the environment, from the proposed dealings are negligible. The risk assessment process considers how the genetic modifications and proposed activities conducted with the GM vaccines might lead to harm to people or the e ...
Introduction to Biological Data
Introduction to Biological Data

... 1a Locus Name (HSHFE) - The locus name is a tag for grouping similar sequences. The first two or three letters usually designate the organism. In this case HS stands for Homo sapiens The last several characters are associated with another group designation, such as gene product. In this example, the ...
Document
Document

... chromosome based on _________________________________ Distances between genes can be expressed as map units; one map unit, or _______________, represents a _____ recombination frequency Map units indicate _______________________ and order, not precise locations of genes Sturtevant used recombination ...
Hypergeometric Tests for Gene Lists
Hypergeometric Tests for Gene Lists

Query Results
Query Results

... Step 4: The user can choose to map the experimental tags against a subset of genomic tags upon a large amount of different features. For details see the help links or: Malig, R., Varela, C., Agosin, E. and Melo, F. (2006) Accurate and unambiguous tag-to-gene mapping in SAGE by a hierarchical gene a ...
Supplementary Results dN/dS Complete results for all three models
Supplementary Results dN/dS Complete results for all three models

... high rates of evolution. However, the difficulties in subdividing these variable groups into correct orthogroups may be the cause of some of these elevated dN/dS values. In our analysis, the PE and PPE gene families were highly enriched for the high- dN/dS orthogroups in the basic model, but we were ...
Informed consent.
Informed consent.

... both parents (familial inheritance), or can be generated for the first time in the egg or sperm that leads to that person (de novo). • An alteration that does not affect the function of the gene or whose possible effects remain unknown, which is called a variant, can be benign or of uncertain signif ...
This project aims to investigate the use of Petri Nets to model
This project aims to investigate the use of Petri Nets to model

Quantitative real-time PCR - Springer Static Content Server
Quantitative real-time PCR - Springer Static Content Server

... variables than samples, so those models which included more predictor genes than samples were omitted from the discriminant analysis simulations. In order to fairly compare the ability to classify using chromosome 21 genes versus non-chromosome 21 genes, the same model space was used for both simula ...
Homology-based cloning and expression analysis of Rf genes
Homology-based cloning and expression analysis of Rf genes

... restoration against cytoplasmic male sterility (CMS). CMS often causes the production of flowers with non-functional pollen, and its corresponding nuclear restoration of fertility (Rf) genes can suppress the expression of CMS inducer genes in mitochondria. The CMS and fertility-restoration system ha ...
How To Use GOstats Testing Gene Lists for GO Term Association 1 Introduction
How To Use GOstats Testing Gene Lists for GO Term Association 1 Introduction

... term is larger than expected. The hyperGTest function provides an implementation of the commonly applied Hypergeometric calculation for over or under-representation of GO terms in a specified gene list. This computation ignores the structure of the GO terms, treating each term as independent from al ...
Kein Folientitel
Kein Folientitel

... 1) Assume that you are interested in the p53-homolog p63, also known as Ket (TrEMBL: Q9UE10) What kind of fragment(s) would you use for expression analysis? Why? 2) The cytochrome P450 family is very important for toxicological microarray analysis since most isoforms repond to different toxic compou ...
Gene Transcription in Prokaryotes
Gene Transcription in Prokaryotes

... • Operons: in prokaryotes, genes that encode protein participating in a common pathway are organized together. – This group of genes, arranged in tandem, is called an OPERON. ...
ppt6
ppt6

... Maximum Parsimony Algorithm (Following Fitch 1971): Start with D=0, up_set[i] a bitvector for each node ...
Comparative DNA Sequence Analysis of Mouse and Human
Comparative DNA Sequence Analysis of Mouse and Human

... Single large exon encodes an 818aa protein containing a signal peptide ...
BISC 6274 - GWU Biology Department
BISC 6274 - GWU Biology Department

... 1. Be aware of the cellular processes involved in the control of gene expression in bacteria leading to metabolic adjustment, virulence and cell differentiation. 2. Appreciate the importance of “model” bacteria for studying the regulation of cell differentiation in prokaryotic and eukaryotic cells. ...
EBI Research - Microarray - Introduction To Biology
EBI Research - Microarray - Introduction To Biology

... Although forces such as hydrogen bonds are weak individually, when two or more biological macromolecules with complementary shapes come close to each other, the sum of all such weak forces may cause the molecules interact rather strongly, e.g., to make them stick together. In fact, such weak inter-m ...
laboratory of developmental genetics and genetic analysis
laboratory of developmental genetics and genetic analysis

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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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