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WORD - ctahr
WORD - ctahr

... species, it has been shown that the genes required for nodulation (nod) and nitrogen fixation (nif) are located on large plasmids (12). The nitrogenase enzyme complex is composed of two enzymes, nitrogenase (Mo-Fe protein) and nitrogenase reductase (Fe protein). The Mo-Fe protein is composed of two ...
Replicational and transcriptional selection on codon usage in
Replicational and transcriptional selection on codon usage in

... (7) and also M. pneumoniae (20). These organisms all seem to be benefiting from a mechanism of genome organization that maintains genes on the leading strand of replication. It is unlikely that this effect is a result of random genetic drift, because there seems to be an obvious selective advantage ...
Carbapenemase and virulence factors of
Carbapenemase and virulence factors of

- Philsci
- Philsci

... One of the earliest accepted definitions of homology was stated by Owen in 1843, as “the same organ in different animals...”. This original concept of homology was defined as structural similarity between organisms and given in terms of their relative position and orientation. However, this definiti ...
Micro Array Explorer MAExplorer
Micro Array Explorer MAExplorer

... • Correlation of gene expression changes with biological state implies a relationship but does not imply cause and effect ...
Complete mitochondrial genome of a natural triploid
Complete mitochondrial genome of a natural triploid

... 2008, was found in Pingxiang district of Jiangxi Province in China, and the ratio of males to females was about 1:10 in natural water areas. Hong et al. (2005) concluded that the fish was a natural triploid crucian carp mutant based on DNA content measurement and chromosome analysis, and it had dual ...
Comparative Sequence Analysis of a Region on Human
Comparative Sequence Analysis of a Region on Human

... as previously described (Kapanadze et al., 1996), and further screened with the above-mentioned probes. PCR and sequencing. Human and mouse RNA (mRNA and total RNA) was purchased directly from Clontech (Palo Alto, CA), and cDNA was prepared with first-strand beads (Ready-To-Go), according to the man ...
11-3 Exploring Mendelian Genetics
11-3 Exploring Mendelian Genetics

... Section 11-3 Exploring Mendelian Genetics ...
The DNA sequence of human chromosome 21
The DNA sequence of human chromosome 21

(2013). Nothing in genetics makes sense except in light of genomic
(2013). Nothing in genetics makes sense except in light of genomic

... selection advantage, causing a maladaptive phenotype to develop in the sex favoring the “losing” allele (Rice 1984). Alternatively, both alleles may sometimes persist as a balanced polymorphism, in which case both sexes are harmed because some individuals of each sex sometimes express the allele tha ...
Supporting Protocols
Supporting Protocols

... replicated to SC-Ura plates and to plates containing lawns of MATa (D297-4B or R113) and MAT tester strains (B3847 or R194). The mating-type switching efficiency was determined by dividing the number of Ura+ MAT colonies with the total number of Ura+ colonies. The numbers are means of five to seve ...
Seed Germination Multiplexed Quantitative Gene Expression
Seed Germination Multiplexed Quantitative Gene Expression

... Slightly more variation was observed in the real time-qPCR analysis compared to the GeXP system. In our experience these differences between expression levels are not biologically significant and can easily arise from random variation inherent ...
Supplementary Methods S2: Exome Sequencing
Supplementary Methods S2: Exome Sequencing

... (i) Preprocessing the aligned reads in the tumor and normal sequencing data. In this step we ignore reads with too many mismatches or very low quality scores since these represent noisy reads that introduce more noise than signal. (ii) A statistical analysis that identifies sites that are likely to ...
Researching causes of schizophrenia: methodological madness
Researching causes of schizophrenia: methodological madness

... • Because of attitudes and values within the medical research profession, it is not likely that anyone from a medical background will identify genuine causes of schizophrenia and other forms of psychosis • Such progress is more likely to come from within the social sciences ...
chesler_reviewer_res..
chesler_reviewer_res..

... authors could carry out such an analysis at every other main effect, how do they arrive at a significant interaction P-value of <0.01? Surely there is an issue of multiple testing here. The method for epistasis detection is not given. *This section can be removed, or simply retitled to reflect it’s ...


... found a single P. mirabilis strain that was resistant to chloramphenicol, trimethoprim/sulfamethoxazole and tetracycline. In a study conducted in France, Even et al. (2010) isolated 33 strains of Staphylococcus epidermidis from cheese and dry fermented sausages samples, and clinical samples from hos ...
Behold the fowls of the air
Behold the fowls of the air

Lecture 14 - The Chromosomal Basis of Inheritance
Lecture 14 - The Chromosomal Basis of Inheritance

... X inactivation in female mammals • One of the two X chromosomes in each cell is randomly inactivated during embryonic development • The inactive X condenses into a Barr body • If a female is heterozygous for a particular gene located on the X chromosome, she will be a mosaic for that character ...
Comprehensive Genetic Testing
Comprehensive Genetic Testing

Human Genetics Course Advisor: Prof Jane Farrar TR073
Human Genetics Course Advisor: Prof Jane Farrar TR073

... In this course we study how proteins evolve from the perspective of their three-dimensional structure. In especial, we examine the main parameters that feature the structure of a protein and how these parameters make proteins robust to translation errors. Proteins are studied since their synthesis u ...
Supporting Information (SI) for “Theoretical models of the influence
Supporting Information (SI) for “Theoretical models of the influence

... 50,000 generations of allopatry allowed sufficient divergence to accumulate such that the populations did not fuse when secondary contact occurred, but (B,F) allopatric divergence for 10,000 generations was followed by fusion of the populations, and then divergence much later. (C,G) We “replayed the ...
Rate Asymmetry After Genome Duplication Causes Substantial
Rate Asymmetry After Genome Duplication Causes Substantial

microarray data analysis using r programming
microarray data analysis using r programming

... Pathway responsible for cause of cancer identified. There are different pathways involved in the cancer but we selected only the P53 signalling pathway and pathways in cancer. From the annotation summary results we have selected only P53 signalling pathway by referring the KEGG chart from which high ...
Yeast genetics to investigate the function of core pre
Yeast genetics to investigate the function of core pre

... A URA3 marked plasmid containing two wild-type genes for complementation of the two gene deletions can be constructed as described above for a URA3 plasmid containing a single gene (3.1.1) by inserting two genes into the MCS instead of one. 3.2.2 Construction of double knockout strains The construct ...
- Purugganan Lab
- Purugganan Lab

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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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