How to minimize “bubble-ascus” abortion in crosses for cytology. Background
... have shown that vegetatively normal haploid isolates from natural populations carry on average one or more deleterious recessive mutations that can be detected when made homozygous by backcrossing. In constructing the widely used Oak Ridge N. crassa wild type strains for use as standards, backcrosse ...
... have shown that vegetatively normal haploid isolates from natural populations carry on average one or more deleterious recessive mutations that can be detected when made homozygous by backcrossing. In constructing the widely used Oak Ridge N. crassa wild type strains for use as standards, backcrosse ...
Acinetobacter baumannii
... pili were present in all fully sequenced A. baumannii isolates included (data not shown). Furthermore, most proteins encoding structural subunits of the type IV pili showed a high level of conservation (e.g. PilB and PilD), except for PilA, the major fimbrial subunit. In P. aeruginosa, a distinctive ...
... pili were present in all fully sequenced A. baumannii isolates included (data not shown). Furthermore, most proteins encoding structural subunits of the type IV pili showed a high level of conservation (e.g. PilB and PilD), except for PilA, the major fimbrial subunit. In P. aeruginosa, a distinctive ...
Andreas Mock Cancer Research UK Cambridge Institute, University
... than a ‘hard’ threshold ττ. However, this hard threshold does not reflect the underlying continuous co-expression measure and leads to a significant loss of information. As a consequence, Horvath and colleagues introduced a new framework for weighted gene co-expression analysis (WGCNA)5. At its core ...
... than a ‘hard’ threshold ττ. However, this hard threshold does not reflect the underlying continuous co-expression measure and leads to a significant loss of information. As a consequence, Horvath and colleagues introduced a new framework for weighted gene co-expression analysis (WGCNA)5. At its core ...
THR_Paper2_CRISPR
... Mechanism of CRISPR/Cas systems Prokaryotic viruses (bacteriophages or phages) are one of the most plentiful organisms on earth, and a major threat to bacteria. CRISPR-Cas immunity is a process of bacteria and archaea to prevent bacteriophage infection by providing quick and forceful adaptation to t ...
... Mechanism of CRISPR/Cas systems Prokaryotic viruses (bacteriophages or phages) are one of the most plentiful organisms on earth, and a major threat to bacteria. CRISPR-Cas immunity is a process of bacteria and archaea to prevent bacteriophage infection by providing quick and forceful adaptation to t ...
Ab initio gene prediction
... probability of being in an intron “state” (based solely on donor sites) Note – these probabilities are qualitative and are intended only to portray the local trends. ...
... probability of being in an intron “state” (based solely on donor sites) Note – these probabilities are qualitative and are intended only to portray the local trends. ...
In(IL mat A
... opposite mating type are heterokaryon-incompatible in the vegetative phase. This hypothesis was supported by the finding that when H4250 duplications are homozygous mat A/mat A or mat a/mat.a, they do not show the DA phenotype. Also, when other duplications are heterozygous for heterokaryon incompat ...
... opposite mating type are heterokaryon-incompatible in the vegetative phase. This hypothesis was supported by the finding that when H4250 duplications are homozygous mat A/mat A or mat a/mat.a, they do not show the DA phenotype. Also, when other duplications are heterozygous for heterokaryon incompat ...
Alpha Thalassemia - ARUP Lab Test Directory
... o Nondeletional α-globin mutations may be pathogenic or benign Both may result in an abnormal protein detectable by Hb evaluation Pathogenic nondeletional mutations often have a more severe effect than single gene deletions • α-globin gene triplications result in three active α-globin genes on a ...
... o Nondeletional α-globin mutations may be pathogenic or benign Both may result in an abnormal protein detectable by Hb evaluation Pathogenic nondeletional mutations often have a more severe effect than single gene deletions • α-globin gene triplications result in three active α-globin genes on a ...
The UCSC Known Genes
... proteins were not available. Hence we decided to develop an automated process to construct the UCSC Known Genes dataset based on the latest protein data from Swiss-Prot/TrEMBL (Bairoch et al., 2005), now also known as UniProt, and the associated mRNA data from GenBank (Benson et al., 2005). While th ...
... proteins were not available. Hence we decided to develop an automated process to construct the UCSC Known Genes dataset based on the latest protein data from Swiss-Prot/TrEMBL (Bairoch et al., 2005), now also known as UniProt, and the associated mRNA data from GenBank (Benson et al., 2005). While th ...
The Modest Beginnings of One Genome Project
... Determining Gene Numbers in the Basement At the time Norm(an) and his laboratory members were labeling genes so they could be either mapped by electron microscopy or enriched or isolated to enable further study. In these very early times of molecular cloning, unless one had a gene or lots of its mRN ...
... Determining Gene Numbers in the Basement At the time Norm(an) and his laboratory members were labeling genes so they could be either mapped by electron microscopy or enriched or isolated to enable further study. In these very early times of molecular cloning, unless one had a gene or lots of its mRN ...
chapter introduction - McGraw
... provides free access to over 80,000 articles from 100 medical journals. Since the site deals with a broad array of biotechnology topics, it is not restricted to genetics. However, because of the centrality of molecular genetics to biotechnology, a vast array of information on genetics is available a ...
... provides free access to over 80,000 articles from 100 medical journals. Since the site deals with a broad array of biotechnology topics, it is not restricted to genetics. However, because of the centrality of molecular genetics to biotechnology, a vast array of information on genetics is available a ...
Finding the genes that direct mammalian development
... that was previously shown to be important in the development of one of the model organisms. Methods for making targeted chromosomal deletions throughout the genome will make region-based screens possible in many genomic regions8,9. In the near future, one important application of region-based screen ...
... that was previously shown to be important in the development of one of the model organisms. Methods for making targeted chromosomal deletions throughout the genome will make region-based screens possible in many genomic regions8,9. In the near future, one important application of region-based screen ...
Full-Text PDF
... Several type I methanotrophs of the family Methylococcaceae isolated and detected in various permanently cold habitats [24], such as Methylosoma difficile [25], Methylobacter tundripaludum [26], Methylomonas scandinavica [27] and Methylomonas paludis [28], have been described as new species or gener ...
... Several type I methanotrophs of the family Methylococcaceae isolated and detected in various permanently cold habitats [24], such as Methylosoma difficile [25], Methylobacter tundripaludum [26], Methylomonas scandinavica [27] and Methylomonas paludis [28], have been described as new species or gener ...
Ch. 21
... the pace of genome sequencing • The most ambitious mapping project to date has been the sequencing of the human genome • Officially begun as the Human Genome Project in 1990, the sequencing was largely ...
... the pace of genome sequencing • The most ambitious mapping project to date has been the sequencing of the human genome • Officially begun as the Human Genome Project in 1990, the sequencing was largely ...
The degenerate Y chromosome – can
... RBMY evolved from a ubiquitously expressed partner RBMX on the X (Delbridge et al. 1999; Mazeyrat et al. 1999), as did the testis-specific TSPY from a ubiquitously expressed TSPX (Delbridge et al. in press) and USP9Y, shown to be required for spermatogenesis in human beings (Sun et al. 1999), and Ub ...
... RBMY evolved from a ubiquitously expressed partner RBMX on the X (Delbridge et al. 1999; Mazeyrat et al. 1999), as did the testis-specific TSPY from a ubiquitously expressed TSPX (Delbridge et al. in press) and USP9Y, shown to be required for spermatogenesis in human beings (Sun et al. 1999), and Ub ...
The Gene Balance Hypothesis: From Classical Genetics to Modern
... As this work continued, trisomics were found for all of the possible 12 chromosomes of Datura, but additional forms continued to arise, each with different characteristics. Some of these new forms accentuated a portion of the phenotypic characteristics of the original set of primary trisomics but we ...
... As this work continued, trisomics were found for all of the possible 12 chromosomes of Datura, but additional forms continued to arise, each with different characteristics. Some of these new forms accentuated a portion of the phenotypic characteristics of the original set of primary trisomics but we ...
Nomenclature I
... families should be used where possible. A stem (or root) symbol as a basis for a symbol series allows easy identification of other family members in both database searches and the literature. Gene family members should be designated by Arabic numerals placed immediately after the gene stem symbol, w ...
... families should be used where possible. A stem (or root) symbol as a basis for a symbol series allows easy identification of other family members in both database searches and the literature. Gene family members should be designated by Arabic numerals placed immediately after the gene stem symbol, w ...
What does the apicoplast do?
... • Apicoplast is home to several biosynthetic pathways that are specific to the parasite • Genetic studies show that some of these pathways are essential to parasite growth • Certain antibiotics that target these pathways in bacteria also inhibit parasites and some show promise in clinical trials • C ...
... • Apicoplast is home to several biosynthetic pathways that are specific to the parasite • Genetic studies show that some of these pathways are essential to parasite growth • Certain antibiotics that target these pathways in bacteria also inhibit parasites and some show promise in clinical trials • C ...
Molecular identification of tick-borne pathogens in
... Haemaphysalis longicornis, confirmed with light microscopy and PCR amplification. The pathogens identified in these ticks included bacteria of the genus Anaplasma (Anaplasma ovis, A. bovis, A. phagocytophilum) and piroplasmal protozoans (Theileria luwenshuni, Babesia motasi). Our results show the hi ...
... Haemaphysalis longicornis, confirmed with light microscopy and PCR amplification. The pathogens identified in these ticks included bacteria of the genus Anaplasma (Anaplasma ovis, A. bovis, A. phagocytophilum) and piroplasmal protozoans (Theileria luwenshuni, Babesia motasi). Our results show the hi ...
Uncovering evolutionary patterns of gene expression using
... have begun to be used in comparative studies of gene expression evolution, providing us with useful insights into several fundamental questions in evolutionary biology. Here, we review the recent literature on the use of highthroughput technologies to study the evolution of gene expression patterns ...
... have begun to be used in comparative studies of gene expression evolution, providing us with useful insights into several fundamental questions in evolutionary biology. Here, we review the recent literature on the use of highthroughput technologies to study the evolution of gene expression patterns ...
A Comparative Genomic Analysis of Two Distant Diptera, the Fruit
... comparative study of genome organization in the main African malaria vector, Anopheles gambiae, relative to the recently determined sequence of the Drosophila melanogaster genome. The ancestral lines of these two dipteran insects are thought to have separated ∼250 Myr, a long period that makes this ...
... comparative study of genome organization in the main African malaria vector, Anopheles gambiae, relative to the recently determined sequence of the Drosophila melanogaster genome. The ancestral lines of these two dipteran insects are thought to have separated ∼250 Myr, a long period that makes this ...
A global test for groups of genes
... expression in gene group B. Basic idea: nA genes in group A, nB genes in group B Order the genes with respect to the expression value. If there is a difference between both groups, the expression values will be separated. The position of a value in group A will have the tendency to be high or low. I ...
... expression in gene group B. Basic idea: nA genes in group A, nB genes in group B Order the genes with respect to the expression value. If there is a difference between both groups, the expression values will be separated. The position of a value in group A will have the tendency to be high or low. I ...