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PSY236 -‐ Biopsychology and Learning
PSY236 -‐ Biopsychology and Learning

... Alterations  or  deletions  of  DNA  sequence  can  be  either  beneficial  or  detrimental:   • Down’s  syndrome  results  from  having  three  chromosomes  instead  of  the  usual  two  at  chromosome   ...
Selection Coevolution
Selection Coevolution

... Red Queen situation: to remain in one place (survive without being vulnerable to pathogens), you have to keep evolving new defenses. In this case there is frequency-dependent selection, where the common phenotype has a reduced fitness (pathogens will easily infect individuals who all have the same i ...
GENETICS
GENETICS

... Chromosome has a completely different chemical composition from the starting two chromosomes. ...
DNA 1: Today`s story, logic & goals
DNA 1: Today`s story, logic & goals

... Lesch KP, et al Science 1996 274:1527-31 Association of anxiety-related traits with a polymorphism in the serotonin transporter ...
The Importance of Genetic Testing
The Importance of Genetic Testing

... -Scans coding region for potential sequence changes - Followed by sequencing to identify the specific change Sequence Analysis - Determines sequence for coding region Resequencing Array -Array (chip) based sequencing - Includes known intronic mutations ...
Chapter 9, part A
Chapter 9, part A

... DNA can be inserted into a cell by: • Microinjection • Gene gun ...
Name: Period _______ Date FINAL EXAM STUDY GUIDE G
Name: Period _______ Date FINAL EXAM STUDY GUIDE G

... Sex-Linked (give an example): Multiple allele traits: Sex chromosomes: Male/Female Karyotype (know how to read and analyze): Be able to analyze blood types as co-dominant and multiple alleles Be able to set up and complete a dihybrid Punnett square and analyze probability ratios for genotype and phe ...
Evolutionary dynamics and emergence of panzootic H5N1 Influenza
Evolutionary dynamics and emergence of panzootic H5N1 Influenza

... • Current models either take the nucleotide or the codon as the unit of evolution • The structure of the genetic code determines that realistic models of evolution should consider triplets of nucleotides (i.e. codons) to be the basic unit of evolution ...
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F plasmid

... - Called attenuator -Like transcriptional terminator Sequence2: 3 pair - weak loop won’t block translation ...
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... mitochondrial DNA (mtDNA). Without sufficient copies of mtDNA, the mitochondria cannot manufacture an adequate amount of ATP, leading to complications in energy expensive tissues such as the brain and liver, ultimately causing death in early infancy. Deoxyguanosine kinase (dGK), an enzymatic protein ...
Bacterial Genetics
Bacterial Genetics

... 1. Base substitutions Silent mutation – No change of amino acid Missense mutation – Switch to another amino acid Nonsense mutation – Change to a stop codon 2. Deletion & Insertion - Change more base pairs in DNA => frameshift => truncated gene product ...
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... • Mobile genetic elements = Transposons • Present in all organisms (yes - even Humans!!) ...
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Etiology of hypoplastic left heart syndrome: insights from mutant
Etiology of hypoplastic left heart syndrome: insights from mutant

... specific genes and mechanism of disease pathogenesis for HLHS is not well understood. In this study, we report findings from the first animal model of HLHS recovered from a large-scale recessive mouse mutagenesis screen. From over 100,000 fetuses ultrasound scanned, only 9 fetuses from 8 mutant line ...
Genetic Mutations
Genetic Mutations

... – nonsense mutations: code for a stop, which can translate the protein – missense mutations: code for a different amino acid – silent mutations: code for the same amino acid ...
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Ch 5
Ch 5

... mRNA attaches to the ribosome. Amino acids are transported to the mRNA by transfer RNA (tRNA). mRNA has codons – a sequence of 3 nucleotides that codes for an amino acid. tRNA has anticodons that are complementary to mRNA’s codons. AUG is the universal ‘start’ codon that tells the ribosome to start ...
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Mr. Carpenter`s Biology RNA 10 Name

...  Transcription factors (regulatory proteins in eukaryotes) help arrange RNA polymerases in the correct position on the ________________________.  A gene can be influenced by many different ________________________ ________________________.  An ________________________ is a sequence of DNA that ca ...
Genetics Slides
Genetics Slides

... Most human traits are polygenic, which means they are controlled by multiple genes. –  This leads to a wide array of phenotypes. –  Simple Punnett squares do NOT work for polygenic traits. §  EX: Human height & eye color. ...
PowerPoint 演示文稿
PowerPoint 演示文稿

... by a loss-of-function. A null allele has total loss-of-function. Dominant alleles are caused by gain-of-function. 6 A mutation consists of a change in the sequence of A T and G C base pairs in DNA. A mutation in a coding sequence may change the sequence of amino acids in the corresponding protein. A ...
Unit 1 - Moodle
Unit 1 - Moodle

... Polynucleotide formation Identify how complimentary base pairing and the hydrogen bonding between two complimentary strands are involved in the formation of the DNA double helix. Identify how Meselson and Stahl’s classic experiment provided new data that supported the accepted theory of replication ...
Genetics - Mr. Coleman's Biology
Genetics - Mr. Coleman's Biology

... Multiple alleles – more than two alleles for a gene are found within a population. Polygenic traits – many genes contribute to a phenotype. ...
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... Multiple alleles – more than two alleles for a gene are found within a population. Polygenic traits – many genes contribute to a phenotype. ...
assignmentschapters16-19and11-1
assignmentschapters16-19and11-1

... to the amino acid sequence or protein produced as a result of this mutation? (Note: Position 1 refers to the first base at the 3 end of the transcribed strand. The last base in the DNA strand, at the 5 end, is at position 21.) ...
Natural selection on the molecular level
Natural selection on the molecular level

... Allowed to develop methods of testing for positive selection (using the neutral model as a null hypothesis) ...
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Mutation



In biology, a mutation is a permanent change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from damage to DNA which is not repaired or to RNA genomes (typically caused by radiation or chemical mutagens), errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity.Mutation can result in several different types of change in sequences. Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Mutations can also occur in nongenic regions. One study on genetic variations between different species of Drosophila suggests that, if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms that have damaging effects, and the remainder being either neutral or weakly beneficial. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent or correct mutations by reverting the mutated sequence back to its original state.
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