Comparative Analysis of Structural Diversity and
... clear genes. Pearson’s correlation test was used to determine if there is any significant correlation between Ks and GC3s or Ks and ENC. The statistically significant level was set at 95%. The statistical analyses were conducted using the program R (http://www.r-project.org/). Results and Discussion ...
... clear genes. Pearson’s correlation test was used to determine if there is any significant correlation between Ks and GC3s or Ks and ENC. The statistically significant level was set at 95%. The statistical analyses were conducted using the program R (http://www.r-project.org/). Results and Discussion ...
Problem Sets - MIT Biology
... dominant phenotypes were used (and these cannot be used in complementation tests), or strains that were not true-breeding were used. Using strains that are not true-breeding is not the proper way to do a complementation test, because then multiple genotypes and phenotypes are produced instead of jus ...
... dominant phenotypes were used (and these cannot be used in complementation tests), or strains that were not true-breeding were used. Using strains that are not true-breeding is not the proper way to do a complementation test, because then multiple genotypes and phenotypes are produced instead of jus ...
p16INK4a immunocytochemical analysis is an
... modify the results. It has been suggested in previous studies that the significance of p16INK4a gene deletions would disappear within the subgroups of T-ALL and B-precursor ALL.16,17 Our data show that T phenotype does not account for the poorer outcome of p16INK4a ICC–negative patients. However, th ...
... modify the results. It has been suggested in previous studies that the significance of p16INK4a gene deletions would disappear within the subgroups of T-ALL and B-precursor ALL.16,17 Our data show that T phenotype does not account for the poorer outcome of p16INK4a ICC–negative patients. However, th ...
chicken.db - Bioconductor
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
A Novel Splicing Mutation of KIT Results in Piebaldism and Auburn
... Piebaldism is a rare autosomal dominant disorder of melanocyte development, which is mostly caused by KIT gene. The key characteristics of piebaldism include localized poliosis, congenital leukoderma, and other variable manifestations. The previous study has illustrated that the homogeneous MC1R (a ...
... Piebaldism is a rare autosomal dominant disorder of melanocyte development, which is mostly caused by KIT gene. The key characteristics of piebaldism include localized poliosis, congenital leukoderma, and other variable manifestations. The previous study has illustrated that the homogeneous MC1R (a ...
Population genetics by Knud Christensen
... 12.2 The significance of artificial insemination for estimation of breeding values ......................................... 92 12.3 Transgene and transgenic animals .............................................................................................................. 93 12.4 Utilization o ...
... 12.2 The significance of artificial insemination for estimation of breeding values ......................................... 92 12.3 Transgene and transgenic animals .............................................................................................................. 93 12.4 Utilization o ...
Thyroid Disease - the British Acupuncture Council
... closely match the default mode network and the anti-correlated task-positive network. The effect of acupuncture on the brain is integrated at multiple levels, down to the brainstem and cerebellum and appears to go beyond either simple placebo or somatosensory needling effects. Needling needs to be d ...
... closely match the default mode network and the anti-correlated task-positive network. The effect of acupuncture on the brain is integrated at multiple levels, down to the brainstem and cerebellum and appears to go beyond either simple placebo or somatosensory needling effects. Needling needs to be d ...
The new cardiac genetic testing panels
... Every application for a new test that is submitted has to include testing criteria. The UKGTN developed the concept of testing criteria as part of the new test application process. Testing criteria define the appropriateness of a genetic test referral, and it is intended that the test is only carrie ...
... Every application for a new test that is submitted has to include testing criteria. The UKGTN developed the concept of testing criteria as part of the new test application process. Testing criteria define the appropriateness of a genetic test referral, and it is intended that the test is only carrie ...
Efficiency of gene silencing in Arabidopsis
... intron-spliced fragments of the target gene whereas transitive vectors have the target sequence fragment adjacent to an intron-spliced, inverted repeat of heterologous origin. Both transitive and hIR constructs facilitated specific and heritable silencing in the three genes studied (AP1, ETTIN and T ...
... intron-spliced fragments of the target gene whereas transitive vectors have the target sequence fragment adjacent to an intron-spliced, inverted repeat of heterologous origin. Both transitive and hIR constructs facilitated specific and heritable silencing in the three genes studied (AP1, ETTIN and T ...
Photodynamic Therapy - Holistic Alternative cancer treatment photo
... in a sequence of photochemical and photobiologic processes that cause irreversible photodamage to tumor tissues. Results from preclinical and clinical studies conducted worldwide over a 25-year period have established photodynamic therapy as a useful treatment approach for some cancers. Since 1993, ...
... in a sequence of photochemical and photobiologic processes that cause irreversible photodamage to tumor tissues. Results from preclinical and clinical studies conducted worldwide over a 25-year period have established photodynamic therapy as a useful treatment approach for some cancers. Since 1993, ...
Red cell pyruvate kinase deficiency: molecular and clinical aspects
... activity has been shown to be of great importance not only for glycolysis itself, but also for the entire cellular metabolism. Thus, one of the main features of this enzyme is its allosteric response to a large number of effectors, whose precise chemical nature depends on the type of organism or tis ...
... activity has been shown to be of great importance not only for glycolysis itself, but also for the entire cellular metabolism. Thus, one of the main features of this enzyme is its allosteric response to a large number of effectors, whose precise chemical nature depends on the type of organism or tis ...
Inverse correlation between SMN1 and SMN2 copy numbers
... between homologous chromosomes during meiosis. Because of the presence of a large inverted repeat in the 5q13 region, and multiple smaller repeats contained therein, the SMN locus is considered highly susceptible to recombination. And, in fact, studies have shown that unequal crossing over at the SM ...
... between homologous chromosomes during meiosis. Because of the presence of a large inverted repeat in the 5q13 region, and multiple smaller repeats contained therein, the SMN locus is considered highly susceptible to recombination. And, in fact, studies have shown that unequal crossing over at the SM ...
Gene Section KLK4 (kallikrein-related peptidase 4) Atlas of Genetics and Cytogenetics
... Hormone dependent cancer. Disease Kallikrein 4 has been reported to be more highly expressed in cancerous than benign prostate tissues at both the mRNA and protein levels. For example, a tissue microarray study carried out on 42 benign and 207 malignant prostate tissues found that KLK4 was more high ...
... Hormone dependent cancer. Disease Kallikrein 4 has been reported to be more highly expressed in cancerous than benign prostate tissues at both the mRNA and protein levels. For example, a tissue microarray study carried out on 42 benign and 207 malignant prostate tissues found that KLK4 was more high ...
Hemophilia
... since the other copy of the gene compensates with a normal product. Having two defective copies of a gene is the only cause of hemophilia in females, ...
... since the other copy of the gene compensates with a normal product. Having two defective copies of a gene is the only cause of hemophilia in females, ...
Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae.
... related: although instances of relationships between the concentrations of metabolites and related biosynthetic enzymes have been described [9,16], other systems-level studies have noted that the majority of individual gene–metabolite correlations that they observed had no direct interpretation [11] ...
... related: although instances of relationships between the concentrations of metabolites and related biosynthetic enzymes have been described [9,16], other systems-level studies have noted that the majority of individual gene–metabolite correlations that they observed had no direct interpretation [11] ...
Biotechnology/Cloning poster - SPARK: Scholarship at Parkland
... but allowing therapeutic cloning). The international stance on cloning is clearer, with the United Nations General Assembly banning all forms of human cloning in 2005, including both reproductive and therapeutic. For these legal reasons as well as ethical reasons, it's probable that the future of cl ...
... but allowing therapeutic cloning). The international stance on cloning is clearer, with the United Nations General Assembly banning all forms of human cloning in 2005, including both reproductive and therapeutic. For these legal reasons as well as ethical reasons, it's probable that the future of cl ...
- LSHTM Research Online
... mean that our understanding of the survival and pathogenesis of this important bacterium at the genetic level is still rudimentary. The size and plasticity of the B. pseudomallei genome as well as the necessity to handle the pathogen under high-level containment conditions have made a comprehensive ...
... mean that our understanding of the survival and pathogenesis of this important bacterium at the genetic level is still rudimentary. The size and plasticity of the B. pseudomallei genome as well as the necessity to handle the pathogen under high-level containment conditions have made a comprehensive ...
Analysis of DNA transcription termination sequences of gene coding
... dissociation of TEC into RNA, DNA and an RNA polymerase, what means the ending of transcription. In this study, the sequences located between phaC1 and phaZ genes in Pseudomonas species were analysed to identify the bacteria for Rho-independent transcription terminator. Five of studied sequences (tw ...
... dissociation of TEC into RNA, DNA and an RNA polymerase, what means the ending of transcription. In this study, the sequences located between phaC1 and phaZ genes in Pseudomonas species were analysed to identify the bacteria for Rho-independent transcription terminator. Five of studied sequences (tw ...
Genetic Polymorphism of Human CYP2E1
... also expressed and induced in the brain after ethanol treatment or ischemia (1, 2) and furthermore is distributed in many other tissues (3). The physiological role of this enzyme seems to be connected mainly with the conversion of acetone to gluconeogenetic precursors. Among the more than 70 differe ...
... also expressed and induced in the brain after ethanol treatment or ischemia (1, 2) and furthermore is distributed in many other tissues (3). The physiological role of this enzyme seems to be connected mainly with the conversion of acetone to gluconeogenetic precursors. Among the more than 70 differe ...
The Mouse Prolactin Gene Family Locus
... incorrect. Members of the PRL family are expressed in celland temporal-specific patterns in the uteroplacental compartment and anterior pituitary (1). An overriding theme characteristic of the PRL family is its association with pregnancy and regulatory mechanisms controlling viviparity. The initial ...
... incorrect. Members of the PRL family are expressed in celland temporal-specific patterns in the uteroplacental compartment and anterior pituitary (1). An overriding theme characteristic of the PRL family is its association with pregnancy and regulatory mechanisms controlling viviparity. The initial ...
High-Dose Ibuprofen in Cystic Fibrosis
... activity of NF-κB and other pro-inflammatory transcription factors [66]. In CF, ibuprofen is administered to achieve low millimolar concentrations in blood plasma. These concentrations could theoretically exert anti-inflammatory effects in CF by suppressing NF-κB and, thus, NF-κB dependent inflammat ...
... activity of NF-κB and other pro-inflammatory transcription factors [66]. In CF, ibuprofen is administered to achieve low millimolar concentrations in blood plasma. These concentrations could theoretically exert anti-inflammatory effects in CF by suppressing NF-κB and, thus, NF-κB dependent inflammat ...
Corticosteroids Therapy for the Tinnitus Associated with Sudden
... underwent intratympanic corticosteroid therapy after failure of corticosteroid therapy orally and those who underwent treatment with oral corticosteroids. No significant differences were observed between these two groups. However, an association was observed between the results obtained by the THI a ...
... underwent intratympanic corticosteroid therapy after failure of corticosteroid therapy orally and those who underwent treatment with oral corticosteroids. No significant differences were observed between these two groups. However, an association was observed between the results obtained by the THI a ...
Table of Contents - Scholars` Bank
... mRNA to distinguish which amino acid was required to construct the desired protein. However, before the “adaptor” could be found, the specifics of the genetic code became known. F. H. C. Crick, J. S. Griffith and L. E. Orgel proposed that codons are three adjacent nucleotides whose unique order corr ...
... mRNA to distinguish which amino acid was required to construct the desired protein. However, before the “adaptor” could be found, the specifics of the genetic code became known. F. H. C. Crick, J. S. Griffith and L. E. Orgel proposed that codons are three adjacent nucleotides whose unique order corr ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.