Copy number variants and genetic traits: closer to the resolution of
... and association studies for polygenic complex traits. This list is not exhaustive, and the literature is continuously expanding with elegant experimental uses of genetic variation. To date, SNPs are the variant type of choice for association studies in common diseases and complex traits. The results ...
... and association studies for polygenic complex traits. This list is not exhaustive, and the literature is continuously expanding with elegant experimental uses of genetic variation. To date, SNPs are the variant type of choice for association studies in common diseases and complex traits. The results ...
Identification of Candidate Genes for Rice Grain Aroma by
... environment it is difficult to identify genes that undermine this trait (Pachauri et al. 2010). Initially, it was reported that rice aroma is controlled by a single dominant gene with a segregation ratio of 3:1 (Kadam and Patankar 1938). Subsequently, Jodon (1944) contradicted this observation and r ...
... environment it is difficult to identify genes that undermine this trait (Pachauri et al. 2010). Initially, it was reported that rice aroma is controlled by a single dominant gene with a segregation ratio of 3:1 (Kadam and Patankar 1938). Subsequently, Jodon (1944) contradicted this observation and r ...
Ovation™ RNA Amplification System
... gene expression) was obtained with QPCR primers and probes (Dual ...
... gene expression) was obtained with QPCR primers and probes (Dual ...
All these mutants are being deposited at FGSC (Table... information will be made available to anyone interested in analyzing...
... close to expectation for random coincidence.] When this is the case, two closely linked markers like galD-pyrG (average 3%, Table 2) can reliably be arranged in sequence only if an outside marker is reasonably close. For example, suAadE, at a distance of less than 10%, mapped closer to pyrG than gal ...
... close to expectation for random coincidence.] When this is the case, two closely linked markers like galD-pyrG (average 3%, Table 2) can reliably be arranged in sequence only if an outside marker is reasonably close. For example, suAadE, at a distance of less than 10%, mapped closer to pyrG than gal ...
Genetic Risk Modeling: An Application of Bayes Nets
... place utility and decision nodes in a Bayes Net (the result is called an Influence Diagram). With these nodes, the net not only can be used to predict probabilities of genotype, disease or outcome, but also to recommend specific cost-effective choices. The recognition that Bayes Nets could be used i ...
... place utility and decision nodes in a Bayes Net (the result is called an Influence Diagram). With these nodes, the net not only can be used to predict probabilities of genotype, disease or outcome, but also to recommend specific cost-effective choices. The recognition that Bayes Nets could be used i ...
Hidradenitis suppurativa/Acne inversa
... considerably over time, but still remains unclear. Due to the specific anatomical distribution of the disease, HS was initially believed to be a disorder of the apocrine glands (1, 2, 4). It is well known, that the apocrine sweat glands, mainly distributed in the axillary and anogenital skin, are ev ...
... considerably over time, but still remains unclear. Due to the specific anatomical distribution of the disease, HS was initially believed to be a disorder of the apocrine glands (1, 2, 4). It is well known, that the apocrine sweat glands, mainly distributed in the axillary and anogenital skin, are ev ...
Gene cloning of P43 surface protein of toxoplasma gondii tachyzoite
... intermediate hosts. The sexual and asexual cycle of parasite respectively takes place in the intestinal epithelial of the cat (as definitive host) and any warm blooded, like mammals and birds (as intermediate hosts) (Frankel et al, 1970). Previous studies have showed that the main human infection ca ...
... intermediate hosts. The sexual and asexual cycle of parasite respectively takes place in the intestinal epithelial of the cat (as definitive host) and any warm blooded, like mammals and birds (as intermediate hosts) (Frankel et al, 1970). Previous studies have showed that the main human infection ca ...
Diagnostic and Prognostic Significance of Gene Expression
... preferentially expressed in lymphoid cells and genes with known or suspected roles in immunology or cancer – 12,069 out of 17,856 cDNA from a germinal center Bcell library – 2,338 cDNA from libraries derived from DLBCL, follicular lymphoma, mantle cell lymphoma, chronic ...
... preferentially expressed in lymphoid cells and genes with known or suspected roles in immunology or cancer – 12,069 out of 17,856 cDNA from a germinal center Bcell library – 2,338 cDNA from libraries derived from DLBCL, follicular lymphoma, mantle cell lymphoma, chronic ...
Cloning and Sequencing of a Gene from Bacillus
... ability to sporulate on further cultures of MY2000.68. Lysates were checked, before testing, to see that there was no bacterial contamination. A single colony was selected from the first sub-culture of one of the eight isolates. This strain was used for all subsequent work. The transducing lysate ob ...
... ability to sporulate on further cultures of MY2000.68. Lysates were checked, before testing, to see that there was no bacterial contamination. A single colony was selected from the first sub-culture of one of the eight isolates. This strain was used for all subsequent work. The transducing lysate ob ...
IMSR File Format
... Embryonic Stem (ES) Cell Undifferentiated cells derived from blastocyst-stage embryos. ES cells can differentiate in culture to a number of different cell types. When incorporated into chimeric mouse embryos they are totipotent and can differentiate into any cell type in the mouse. If these cells be ...
... Embryonic Stem (ES) Cell Undifferentiated cells derived from blastocyst-stage embryos. ES cells can differentiate in culture to a number of different cell types. When incorporated into chimeric mouse embryos they are totipotent and can differentiate into any cell type in the mouse. If these cells be ...
Gene Section IGH (Immunoglobulin Heavy) Atlas of Genetics and Cytogenetics
... Seven non-mapped IGHV genes have been described as insertion/deletion polymorphism but have not yet been precisely located. The most 5' IGHV genes occupy a position very close to the chromosome 14q telomere whereas the IGHC genes are in a more centromeric position. The potentiel genomic IGH repertoi ...
... Seven non-mapped IGHV genes have been described as insertion/deletion polymorphism but have not yet been precisely located. The most 5' IGHV genes occupy a position very close to the chromosome 14q telomere whereas the IGHC genes are in a more centromeric position. The potentiel genomic IGH repertoi ...
Genetic Risk Modeling: An Application of Bayes Nets
... place utility and decision nodes in a Bayes Net (the result is called an Influence Diagram). With these nodes, the net not only can be used to predict probabilities of genotype, disease or outcome, but also to recommend specific cost-effective choices. The recognition that Bayes Nets could be used i ...
... place utility and decision nodes in a Bayes Net (the result is called an Influence Diagram). With these nodes, the net not only can be used to predict probabilities of genotype, disease or outcome, but also to recommend specific cost-effective choices. The recognition that Bayes Nets could be used i ...
View Full PDF - Biochemical Society Transactions
... unguiculata are found in a separated, deep branch. This distribution suggests distinct evolutionary origins for hydrogenase genes in Bradyrhizobium. In addition, the phylogenetic analysis of hup genes showed minimal distances between hup ...
... unguiculata are found in a separated, deep branch. This distribution suggests distinct evolutionary origins for hydrogenase genes in Bradyrhizobium. In addition, the phylogenetic analysis of hup genes showed minimal distances between hup ...
Canine Hyperadrenocorticism - VCA Specialty Animal Hospitals
... B. Insulin requirements may change rapidly. Owner should monitor urine samples 2-3 times a day for glucose. With negative results, insulin dose is lowered 25% at next injection. C. Cortisol causes insulin antagonism so with resolution of hyperadrenocorticism: 1. Insulin requirements will decrease. 2 ...
... B. Insulin requirements may change rapidly. Owner should monitor urine samples 2-3 times a day for glucose. With negative results, insulin dose is lowered 25% at next injection. C. Cortisol causes insulin antagonism so with resolution of hyperadrenocorticism: 1. Insulin requirements will decrease. 2 ...
Final Paper
... diseases ranging from cholera to potentially AIDS. Such developments have profound implications for improving human health worldwide and save millions of lives. It has been shown that plants have a great economic value to pharmaceuticals, cosmetics, and other industries. As the world population cont ...
... diseases ranging from cholera to potentially AIDS. Such developments have profound implications for improving human health worldwide and save millions of lives. It has been shown that plants have a great economic value to pharmaceuticals, cosmetics, and other industries. As the world population cont ...
CyKEGGParser User Manual - Institute of Molecular Biology NAS RA
... KEGG pathways are generalized pathways, with nodes representing collections of gene products, with abstract interactions between them, not always occurring together in the same biological context. Specifically, one of the abstractions is that paralogous genes/gene products are grouped into one node. ...
... KEGG pathways are generalized pathways, with nodes representing collections of gene products, with abstract interactions between them, not always occurring together in the same biological context. Specifically, one of the abstractions is that paralogous genes/gene products are grouped into one node. ...
Single-Molecule Analysis of Translational Dynamics.
... genome diversity, and many questions remain about how an individual human's genome is edited by these two processes. Here, we describe a high-throughput method for single-cell wholegenome analysis that was used to measure the genomic diversity in one individual's gamete genomes. A microfluidic syste ...
... genome diversity, and many questions remain about how an individual human's genome is edited by these two processes. Here, we describe a high-throughput method for single-cell wholegenome analysis that was used to measure the genomic diversity in one individual's gamete genomes. A microfluidic syste ...
VOLUME 31 ISSUE 9 ... EDITOR: KEITH BERMAN ... ISSN 0742-7719
... Study of its autologous hematopoietic stem cell gene therapy, “BB305” or LentiGlobin, for the treatment of beta-thalassemia major. The first of up to 15 subjects was transplanted last month. A separate Phase I/II trial of LentiGlobin for beta-thalassemia major is also underway in France. The disease ...
... Study of its autologous hematopoietic stem cell gene therapy, “BB305” or LentiGlobin, for the treatment of beta-thalassemia major. The first of up to 15 subjects was transplanted last month. A separate Phase I/II trial of LentiGlobin for beta-thalassemia major is also underway in France. The disease ...
Letter Neighboring Genes Show
... 2004). Closely located genes show more similar gene expression patterns than randomly chosen gene pairs. The general phenomenon of coexpression of neighboring genes has been reported in several model eukaryotes such as Saccharomyces cerevisiae (Kruglyak and Tang 2000; Fukuoka et al. 2004; Lercher an ...
... 2004). Closely located genes show more similar gene expression patterns than randomly chosen gene pairs. The general phenomenon of coexpression of neighboring genes has been reported in several model eukaryotes such as Saccharomyces cerevisiae (Kruglyak and Tang 2000; Fukuoka et al. 2004; Lercher an ...
BGS 99, Lesser internode number 1, lin1
... Triple Bearded Mariout (BGS 57) made study of lin1 locus difficult in some environments; therefore, a new BGS number was recommended (2). In some six-rowed cultivars such as Morex, the reduction in rachis internodes associated with the lin1 gene is less obvious (1). A significant reduction triplet n ...
... Triple Bearded Mariout (BGS 57) made study of lin1 locus difficult in some environments; therefore, a new BGS number was recommended (2). In some six-rowed cultivars such as Morex, the reduction in rachis internodes associated with the lin1 gene is less obvious (1). A significant reduction triplet n ...
Somatic MEN1 gene mutation does not contribute
... pituitary adenomas. Indeed, Zhuang et al. using single strand conformational polymorphism analysis found only 2 missense mutations among 4 pituitary adenomas with LOH for MEN1 in a sample of 39 sporadic tumours (9). Prezant et al. using dideoxy fingerprinting analysis (which is more sensitive) studi ...
... pituitary adenomas. Indeed, Zhuang et al. using single strand conformational polymorphism analysis found only 2 missense mutations among 4 pituitary adenomas with LOH for MEN1 in a sample of 39 sporadic tumours (9). Prezant et al. using dideoxy fingerprinting analysis (which is more sensitive) studi ...
Conservation and co-option in developmental programmes: the
... One of the surprising insights gained from research in evolutionary developmental biology (evodevo) is that increasing diversity in body plans and morphology in organisms across animal phyla are not reflected in similarly dramatic changes at the level of gene composition of their genomes. For instan ...
... One of the surprising insights gained from research in evolutionary developmental biology (evodevo) is that increasing diversity in body plans and morphology in organisms across animal phyla are not reflected in similarly dramatic changes at the level of gene composition of their genomes. For instan ...
Conservation and co-option in developmental programmes: the
... One of the surprising insights gained from research in evolutionary developmental biology (evodevo) is that increasing diversity in body plans and morphology in organisms across animal phyla are not reflected in similarly dramatic changes at the level of gene composition of their genomes. For instan ...
... One of the surprising insights gained from research in evolutionary developmental biology (evodevo) is that increasing diversity in body plans and morphology in organisms across animal phyla are not reflected in similarly dramatic changes at the level of gene composition of their genomes. For instan ...
Noradrenaline and hsp70 expression in mollusc immune cells
... Furthermore, exposure of hemocytes to NA or to the αINTRODUCTION The induction of ‘heat shock’ or ‘stress’ proteins represents a homeostatic defense mechanism of cells in response to metabolic and environmental insults. Heat shock proteins (hsp) are encoded by a family of highly conserved genes pres ...
... Furthermore, exposure of hemocytes to NA or to the αINTRODUCTION The induction of ‘heat shock’ or ‘stress’ proteins represents a homeostatic defense mechanism of cells in response to metabolic and environmental insults. Heat shock proteins (hsp) are encoded by a family of highly conserved genes pres ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.