Caffeoylquinic acids as inhibitors for HIV-I protease and HIV
... the fact that they do not contain any macro cycles or resemble the conformation of a β-strand protein. The results from the blind docking also support this as all molecules were docked with a very similar conformation at the active site (data not shown). Conclusion Naturally occurring caffeoylquinic ...
... the fact that they do not contain any macro cycles or resemble the conformation of a β-strand protein. The results from the blind docking also support this as all molecules were docked with a very similar conformation at the active site (data not shown). Conclusion Naturally occurring caffeoylquinic ...
bme-biochem-3-kh-enzymes-9
... Enzymes are mostly proteins They are highly specific to a reaction They catalyze many reactions including breaking down nutrients, storing and releasing energy, creating new molecules, and coordinating biological reactions. Enzymes use an active site, but can be affected by bonding at other areas ...
... Enzymes are mostly proteins They are highly specific to a reaction They catalyze many reactions including breaking down nutrients, storing and releasing energy, creating new molecules, and coordinating biological reactions. Enzymes use an active site, but can be affected by bonding at other areas ...
757 (Agus Kurnia)ok
... conserved in all bacterial xylanases (Figure 1), while that of at the position of 227 was asparagine (N) in GX WBI and GTX, and it was glutamate (E) in BX NG-27, BHX, and BFX. Interestingly, amino acid residue at the position 227 in GSX T-6 was aspartate (D). It was seemed that strongly ionic bindin ...
... conserved in all bacterial xylanases (Figure 1), while that of at the position of 227 was asparagine (N) in GX WBI and GTX, and it was glutamate (E) in BX NG-27, BHX, and BFX. Interestingly, amino acid residue at the position 227 in GSX T-6 was aspartate (D). It was seemed that strongly ionic bindin ...
enzyme
... positively charged Lys or Arg residues H2N-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Lys-Ile-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr------ ...
... positively charged Lys or Arg residues H2N-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Lys-Ile-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr------ ...
Amino Acid Requirements for Formation of the
... procedure was doubtful since the curves varied somewhat in form and it was difficult to decide the incubation times required to produce cultures of strictly comparable physiological age. Forunately, however, the ' age of culture' effect proved to be very much less marked on simple media. Both the ba ...
... procedure was doubtful since the curves varied somewhat in form and it was difficult to decide the incubation times required to produce cultures of strictly comparable physiological age. Forunately, however, the ' age of culture' effect proved to be very much less marked on simple media. Both the ba ...
bimat.org
... composites of CaCO3 crystals and organic polymers exhibiting exceptional nanoscale regularity and strength (1–14). Nacre, the lustrous material of pearl and the inner “mother of pearl” layers of many shells, exhibits a fracture toughness ;3,000 times greater than that of the mineral alone (15, 16). ...
... composites of CaCO3 crystals and organic polymers exhibiting exceptional nanoscale regularity and strength (1–14). Nacre, the lustrous material of pearl and the inner “mother of pearl” layers of many shells, exhibits a fracture toughness ;3,000 times greater than that of the mineral alone (15, 16). ...
Serine racemase: a KEY PLAYER in NEURON activity and in
... parallel -sheet surrounded by three -helices, one located on the solvent side and two at the domains interface. The small and large domains are connected by a flexible hinge region formed by amino acids 69-77, not fully detected in the hSR structure. In the SpSR, the PLP cofactor is bound to Lys56 ...
... parallel -sheet surrounded by three -helices, one located on the solvent side and two at the domains interface. The small and large domains are connected by a flexible hinge region formed by amino acids 69-77, not fully detected in the hSR structure. In the SpSR, the PLP cofactor is bound to Lys56 ...
Divergent evolution of the thiolase superfamily and chalcone
... (HMGS) also contains the CHN triad, although it catalyzes a non-decarboxylative condensation. That the enzymes of the thiolase superfamily share overall similarity in protein structure and function suggested a common evolutionary origin. All thiolases were found to have, in addition to the Cys–His d ...
... (HMGS) also contains the CHN triad, although it catalyzes a non-decarboxylative condensation. That the enzymes of the thiolase superfamily share overall similarity in protein structure and function suggested a common evolutionary origin. All thiolases were found to have, in addition to the Cys–His d ...
Using pyruvic acid as a solvent for dynamic nuclear
... evaluations. Recently, hyperpolarized 13C labeled pyruvate has been used in a prove-of-concept clinical trial in prostate cancer patients (3). Although neat pyruvic acid is typically used as the sole substrate in the DNP sample matrix, it may be feasible to use pyruvic acid as the solvent and dissol ...
... evaluations. Recently, hyperpolarized 13C labeled pyruvate has been used in a prove-of-concept clinical trial in prostate cancer patients (3). Although neat pyruvic acid is typically used as the sole substrate in the DNP sample matrix, it may be feasible to use pyruvic acid as the solvent and dissol ...
Amino Acids - Portal UniMAP
... when amino acid is dissolved in water, it exist predominantly in the isoelectric form Upon titration with base, it act as an acid (donate proton) Upon titration with acid, it act as a base (accept proton) ...
... when amino acid is dissolved in water, it exist predominantly in the isoelectric form Upon titration with base, it act as an acid (donate proton) Upon titration with acid, it act as a base (accept proton) ...
Sample questions from old exam I BCHS 3304 – Dr. Yeo T
... In the tripeptide Arg-Pro-Tyr, the C-terminal residue is Arg. Open systems, such as living creatures, are not at equilibrium. ...
... In the tripeptide Arg-Pro-Tyr, the C-terminal residue is Arg. Open systems, such as living creatures, are not at equilibrium. ...
exam I keys
... In the tripeptide Arg-Pro-Tyr, the C-terminal residue is Arg. Open systems, such as living creatures, are not at equilibrium. ...
... In the tripeptide Arg-Pro-Tyr, the C-terminal residue is Arg. Open systems, such as living creatures, are not at equilibrium. ...
Amino Acids and Simple Proteins
... This research programme enables the studets to progress their understanding of biochemistry and molecular biology to an advanced level and to contribute to the progression of research in this specialist field. The practical laboratory skills the students develop on this programme will be vital to th ...
... This research programme enables the studets to progress their understanding of biochemistry and molecular biology to an advanced level and to contribute to the progression of research in this specialist field. The practical laboratory skills the students develop on this programme will be vital to th ...
Concept 3.1 Nucleic Acids Are Informational
... the 2nd Law of thermodynamics? • The entropy of a system may decrease, but the entropy of the system plus its surroundings must always increase. If the system is open, highly ordered organisms don’t violate the 2nd law. • They maintain highly ordered structure at the expense of increased entropy of ...
... the 2nd Law of thermodynamics? • The entropy of a system may decrease, but the entropy of the system plus its surroundings must always increase. If the system is open, highly ordered organisms don’t violate the 2nd law. • They maintain highly ordered structure at the expense of increased entropy of ...
Catalytic triad
A catalytic triad refers to the three amino acid residues that function together at the centre of the active site of some hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). An Acid-Base-Nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to regenerate free enzyme. The nucleophile is most commonly a serine or cysteine amino acid, but occasionally threonine. Because enzymes fold into complex three-dimensional structures, the residues of a catalytic triad can be far from each other along the amino-acid sequence (primary structure), however, they are brought close together in the final fold.As well as divergent evolution of function (and even the triad's nucleophile), catalytic triads show some of the best examples of convergent evolution. Chemical constraints on catalysis have led to the same catalytic solution independently evolving in at least 23 separate superfamilies. Their mechanism of action is consequently one of the best studied in biochemistry.