How to write research & review articles !!!
... (mOzn), thiazoline (Tzn), 3-amino-6-hydroxy-2-piperidone (Ahp) c) With fatty acid acyl chains or even more complex ‘with galactose bridges’ and ‘histidino-tyrosine moiety’. * Proteins (actin, myocin, myoglobulin) are polypeptides in folded form which function as enzymes (Human glyoxalase I), hormone ...
... (mOzn), thiazoline (Tzn), 3-amino-6-hydroxy-2-piperidone (Ahp) c) With fatty acid acyl chains or even more complex ‘with galactose bridges’ and ‘histidino-tyrosine moiety’. * Proteins (actin, myocin, myoglobulin) are polypeptides in folded form which function as enzymes (Human glyoxalase I), hormone ...
(HMG-CoA) REDUCTASE INHIBITORS ON THE CYP3A4
... administered in the active acid form, there was no evidence suggesting any drug interaction with itraconazole either in clinical situations (Neuvonen and Jalava, 1996; Neuvonen et al., 1998) or in vitro (Ishigami et al., submitted). These results strongly suggest that pravastatin does not exhibit a ...
... administered in the active acid form, there was no evidence suggesting any drug interaction with itraconazole either in clinical situations (Neuvonen and Jalava, 1996; Neuvonen et al., 1998) or in vitro (Ishigami et al., submitted). These results strongly suggest that pravastatin does not exhibit a ...
REVIEW ARTICLE
... dose, potential drug of choice for travelers to endemic areas for short periods and can be stopped immediately upon leaving endemic are, chemoprophylactic property against vivax & falciparum& has potential for radical cure of P. vivax but it is not prescribed in G6PD deficiency due to risk of hemoly ...
... dose, potential drug of choice for travelers to endemic areas for short periods and can be stopped immediately upon leaving endemic are, chemoprophylactic property against vivax & falciparum& has potential for radical cure of P. vivax but it is not prescribed in G6PD deficiency due to risk of hemoly ...
Pharmacology lecture 1 Dr. Sameer Al
... Advantages of PG over Oxytocin [ which also used in labor] : a- PGs are more safe in pregnant women with pre-eclampsia , cardiac and renal diseases . b- PGs unlike Oxytocin, having no anti-diuretic effect. PGE2 and PGF2α are involved in primary dysmenorrhia. PGE1 is used in sexual dysfunction , inje ...
... Advantages of PG over Oxytocin [ which also used in labor] : a- PGs are more safe in pregnant women with pre-eclampsia , cardiac and renal diseases . b- PGs unlike Oxytocin, having no anti-diuretic effect. PGE2 and PGF2α are involved in primary dysmenorrhia. PGE1 is used in sexual dysfunction , inje ...
Mechanism of action
... Misoprostol is Abortificient drug (stimulate uterine contraction), so it should not be used during pregnancy. Drug interactions: No significant drug interactions are reported. (III) Drugs that do not directly inhibit gastric acid secretion. (1) Colloidal bismuth compounds: they include:Bismuth subsa ...
... Misoprostol is Abortificient drug (stimulate uterine contraction), so it should not be used during pregnancy. Drug interactions: No significant drug interactions are reported. (III) Drugs that do not directly inhibit gastric acid secretion. (1) Colloidal bismuth compounds: they include:Bismuth subsa ...
Alex A. Adjei, Roswell Park Cancer Institute, Buffalo, NY
... • MTD may not be the goal of Phase I as specificity of effect may be lost at MTD • Pharmacological effect may not equal biological effect • Goal: Identify OBED ...
... • MTD may not be the goal of Phase I as specificity of effect may be lost at MTD • Pharmacological effect may not equal biological effect • Goal: Identify OBED ...
DPP-4 inhibitors
... data reported a small increased risk of • nasopharyngitis (relative risk [RR] 1.2, 95% CI 1.0-1.4) • urinary tract infection (RR 1.5, 95% CI 1.02.2), and • headache (RR 1.4, 95% CI 1.1-1.7) [7 ...
... data reported a small increased risk of • nasopharyngitis (relative risk [RR] 1.2, 95% CI 1.0-1.4) • urinary tract infection (RR 1.5, 95% CI 1.02.2), and • headache (RR 1.4, 95% CI 1.1-1.7) [7 ...
Exam One Notes
... 2. Trapping of chlororquine in the malaria lysosome increases pH, which inactivates hemoglobin-digesting enzymes. - This will disrupt the pH-sensitive proteolytic enzymes & inactivate the lysosomal proton pump. Mechanism of Resistance to Quinolines: - Several chlororquine& other quinolines resistant ...
... 2. Trapping of chlororquine in the malaria lysosome increases pH, which inactivates hemoglobin-digesting enzymes. - This will disrupt the pH-sensitive proteolytic enzymes & inactivate the lysosomal proton pump. Mechanism of Resistance to Quinolines: - Several chlororquine& other quinolines resistant ...
Serotonin-Norepinephrine Reuptake Inhibitors
... These three biogenic monoamines are associated with depression and increasing the availability in the brain is one method used to treat the condition. SNDRIs are so-called triple reuptake inhibitors (TRIs), which elevate extracellular plasma concentrations of all three monoamine neurotransmitters, s ...
... These three biogenic monoamines are associated with depression and increasing the availability in the brain is one method used to treat the condition. SNDRIs are so-called triple reuptake inhibitors (TRIs), which elevate extracellular plasma concentrations of all three monoamine neurotransmitters, s ...
Histone Deacetylase Inhibitors: Updated Studies in Various
... apoptotic signals and osteoblast differentiation pathways [42]. Unfortunately, TSA 7 did not meet the high expectations regarding its activity in clinical trials, possibly due to its low biodistribution and rapid metabolism [43]. Despite this, Ranganathan et al. were able to demonstrate that TSA cou ...
... apoptotic signals and osteoblast differentiation pathways [42]. Unfortunately, TSA 7 did not meet the high expectations regarding its activity in clinical trials, possibly due to its low biodistribution and rapid metabolism [43]. Despite this, Ranganathan et al. were able to demonstrate that TSA cou ...
Angiotensin-Converting Enzyme Inhibitors
... resistance but cause little change in heart rate With chronic ACE inhibition, AT II and aldosterone levels tend to return to pretreatment levels (AJC ...
... resistance but cause little change in heart rate With chronic ACE inhibition, AT II and aldosterone levels tend to return to pretreatment levels (AJC ...
Document
... Norepinephrine reuptake inhibitors (NRIs), also known as noradrenaline reuptake inhibitors (NARIs), are compounds that elevate the extracellular level of the neurotransmitter norepinephrine in the central nervous system by inhibiting its reuptake from the synaptic cleft into the presynaptic neuronal ...
... Norepinephrine reuptake inhibitors (NRIs), also known as noradrenaline reuptake inhibitors (NARIs), are compounds that elevate the extracellular level of the neurotransmitter norepinephrine in the central nervous system by inhibiting its reuptake from the synaptic cleft into the presynaptic neuronal ...
Simvastatin and atorvastatin: beware of potential CYP3A4
... enzyme (Table 1) are likely to affect the plasma concentration of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one study which investigated the effect of erythromycin (a poten ...
... enzyme (Table 1) are likely to affect the plasma concentration of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one study which investigated the effect of erythromycin (a poten ...
CLINICALLY IMPORTANT DRUG INTERACTIONS
... Drug interaction refers to modification of response to one drug by another when they are administered simultaneously or in quick succession. ...
... Drug interaction refers to modification of response to one drug by another when they are administered simultaneously or in quick succession. ...
alkaloid discovery as natural acetylcholinesterase
... major therapeutic strategies is to inhibit the biological activity of AChE, increasing the acetylcholine level in the brain. However, one of the major limitations of up-regulating AChE activity through acetycholinesterase inhibition is that repeated doses of acetylcholinesterase inhibitor (AChEi) le ...
... major therapeutic strategies is to inhibit the biological activity of AChE, increasing the acetylcholine level in the brain. However, one of the major limitations of up-regulating AChE activity through acetycholinesterase inhibition is that repeated doses of acetylcholinesterase inhibitor (AChEi) le ...
Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus
... JEFBOBMPHVFTBOETFSJOFQSPUFBTFJOIJCJUPST SFTQFDUJWFMZ ...
... JEFBOBMPHVFTBOETFSJOFQSPUFBTFJOIJCJUPST SFTQFDUJWFMZ ...
The potential use of single-particle electron microscopy as a tool for
... inhibitor complex (Steuber et al., 2006; Davis et al., 2008). These problems, in particular the generation of high-quality crystals, have a significant impact in the membrane-protein field. For example, despite the PDB containing over 100 000 deposited X-ray crystal structures of proteins, only a sm ...
... inhibitor complex (Steuber et al., 2006; Davis et al., 2008). These problems, in particular the generation of high-quality crystals, have a significant impact in the membrane-protein field. For example, despite the PDB containing over 100 000 deposited X-ray crystal structures of proteins, only a sm ...
Respiratory Pharmacology Week 6
... SVN: 20 mg / ampule or 20 mg / 2 ml Adults and children > 2 years: 20 mg inhaled four times daily Spray: 40 mg / ml (4%) Adults and children > 2 years: 1 spray each nostril, 3 to 6 times daily every 4 – 6 hours ...
... SVN: 20 mg / ampule or 20 mg / 2 ml Adults and children > 2 years: 20 mg inhaled four times daily Spray: 40 mg / ml (4%) Adults and children > 2 years: 1 spray each nostril, 3 to 6 times daily every 4 – 6 hours ...
PHARMACOTHERAPY OF HYPERTENSION
... activating glutathione and release NO used in hypertensive emergency produce controlled hypotension if it is administered continuously release cyanide and latter converted to thiocyanate and cause psychosis. Also cause palpitation, lactic acidosis, vomiting & pain abdomen. ...
... activating glutathione and release NO used in hypertensive emergency produce controlled hypotension if it is administered continuously release cyanide and latter converted to thiocyanate and cause psychosis. Also cause palpitation, lactic acidosis, vomiting & pain abdomen. ...
2nd T. 5th L. Updated
... administration. Peak plasma concentrations of sulindac are attained within 1 to 2 hrs, while those of the sulfide metabolite occur about 8 hrs after the oral administration of sulindac The t1/2 of sulindac itself is about 7 hrs, but the active sulfide has a t1/2 as long as 18 hrs. Sulindac and its ...
... administration. Peak plasma concentrations of sulindac are attained within 1 to 2 hrs, while those of the sulfide metabolite occur about 8 hrs after the oral administration of sulindac The t1/2 of sulindac itself is about 7 hrs, but the active sulfide has a t1/2 as long as 18 hrs. Sulindac and its ...
COX-2 inhibitors
... years unless specifically indicated, e.g. for juvenile arthritis (paracetamol is preferred). Postmyocardial infarction and poststroke patients. By inhibiting platelet aggregation in low doses (100 mg daily) aspirin decreases the incidence of reinfarction. ...
... years unless specifically indicated, e.g. for juvenile arthritis (paracetamol is preferred). Postmyocardial infarction and poststroke patients. By inhibiting platelet aggregation in low doses (100 mg daily) aspirin decreases the incidence of reinfarction. ...
Print this article - Research in Pharmaceutical Sciences
... 14) and sodium stibogluconate(Pentostam) (C12H40Na3O26Sb2, Fig.15) have been used as first line drugs to treat cutaneous leishmaniasis for the past 50 years (30). In case of antimony treatment of schistosomiasis, antimony attached itself to sulphur atoms in trypanothione reductase (the putative enzy ...
... 14) and sodium stibogluconate(Pentostam) (C12H40Na3O26Sb2, Fig.15) have been used as first line drugs to treat cutaneous leishmaniasis for the past 50 years (30). In case of antimony treatment of schistosomiasis, antimony attached itself to sulphur atoms in trypanothione reductase (the putative enzy ...
Diversity Analysis - ACS Division of Chemical Information
... structures, e.g., natural products that are high-affinity compounds (NPY or taxol are leads!) or from “druglike” leads that are marketed structures (e.g., salbutamol or HTS actives from “normal” combichem) ...
... structures, e.g., natural products that are high-affinity compounds (NPY or taxol are leads!) or from “druglike” leads that are marketed structures (e.g., salbutamol or HTS actives from “normal” combichem) ...
Lecture 05 - binding quant - Cal State LA
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...