Pharmacological Effects of Rutaecarpine, an Alkaloid Isolated from
... Chinese herbs have been widely used as important remedies in oriental medicine and in recent decades many biologically active constituents of selected herbs have been isolated and evaluated for their pharmacological activity. Evodia rutaecarpa (Chinese name: WuChu-Yu) is a well-known traditional Chi ...
... Chinese herbs have been widely used as important remedies in oriental medicine and in recent decades many biologically active constituents of selected herbs have been isolated and evaluated for their pharmacological activity. Evodia rutaecarpa (Chinese name: WuChu-Yu) is a well-known traditional Chi ...
Structural biology and drug discovery
... kinase assisted in understanding retrospectively how structural mutations in ABL can circumvent the anticancer activity of the compound [12,13]. Another anticancer kinase inhibitor drug, Tarceva, was approved by the FDA in 2004 for the treatment of locally advanced or metastatic non-small cell lung ...
... kinase assisted in understanding retrospectively how structural mutations in ABL can circumvent the anticancer activity of the compound [12,13]. Another anticancer kinase inhibitor drug, Tarceva, was approved by the FDA in 2004 for the treatment of locally advanced or metastatic non-small cell lung ...
Site-Directed Mutagenesis of Predicted Active Site Residues in
... Mental Health 5-T32-MH14275–21 (to B.K. Madras), and 1 F32 MH11895– 01 (to H.S.S.). ...
... Mental Health 5-T32-MH14275–21 (to B.K. Madras), and 1 F32 MH11895– 01 (to H.S.S.). ...
Metabolism of drugs
... •Amide drugs are more resistant to hydrolysis (or they are not hydrolyzed until they reach the liver) than ester drugs which they are susceptible to plasma esterase. •The duration of actions of ester drugs are less than the amide analogues. Example: Procaine (ester type) injection or topical is usua ...
... •Amide drugs are more resistant to hydrolysis (or they are not hydrolyzed until they reach the liver) than ester drugs which they are susceptible to plasma esterase. •The duration of actions of ester drugs are less than the amide analogues. Example: Procaine (ester type) injection or topical is usua ...
Esters and amides of hexanoic acid substituted with
... prepared.3 The distance of 5 carbon atoms between the terminal amino group and the carboxyl as well as the range of lengths of alkyl chains were selected based on previous experiences. The older results demonstrated that alkyl esters of ω-amino acids have their optimum transdermal permeation enhanci ...
... prepared.3 The distance of 5 carbon atoms between the terminal amino group and the carboxyl as well as the range of lengths of alkyl chains were selected based on previous experiences. The older results demonstrated that alkyl esters of ω-amino acids have their optimum transdermal permeation enhanci ...
Pharmacology-Drugs For Parkinson
... iii. MAO inhibitors b. Decrease Acetylcholine activity i. Anticholinergics Drugs Used for PD a. Levodopa (L-Dopa) i. Most reliable and effective drug used for PD ii. It is the biochemical precursor to dopamine- dopamine cannot cross BBB but levodopa can. iii. Transmitted into brain by amino acid tra ...
... iii. MAO inhibitors b. Decrease Acetylcholine activity i. Anticholinergics Drugs Used for PD a. Levodopa (L-Dopa) i. Most reliable and effective drug used for PD ii. It is the biochemical precursor to dopamine- dopamine cannot cross BBB but levodopa can. iii. Transmitted into brain by amino acid tra ...
2 Non-steroidal anti-inflammatory drugs
... They are classified according to their action on COX-enzymes into nonselective that inhibit both COX-1 & COX-2 & selective that inhibit only COX-2 enzymes. They are sharing in common therapeutic uses as analgesic to relief mild to moderate pain not visceral pain , reducing high body temperature, ...
... They are classified according to their action on COX-enzymes into nonselective that inhibit both COX-1 & COX-2 & selective that inhibit only COX-2 enzymes. They are sharing in common therapeutic uses as analgesic to relief mild to moderate pain not visceral pain , reducing high body temperature, ...
Document
... associated with severe neurological diseases resulting in high mortality [1-3]. In 1995, EV71 virus was isolated from HFMD cases in Wuhan, China. In 1998, a HFMD outbreak caused by EV71 affected more than 100,000 young children in Taiwan and resulted in 78 deaths [4,5]. During the period from Septem ...
... associated with severe neurological diseases resulting in high mortality [1-3]. In 1995, EV71 virus was isolated from HFMD cases in Wuhan, China. In 1998, a HFMD outbreak caused by EV71 affected more than 100,000 young children in Taiwan and resulted in 78 deaths [4,5]. During the period from Septem ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
... Antioxidants are the bioactive chemical compounds which are highly important to fight against oxidative stress which is responsible for various diseases including cancer. Oxidative stress produces due to the accumulation of free radicals. Free radicals interfere with different process in the body by ...
... Antioxidants are the bioactive chemical compounds which are highly important to fight against oxidative stress which is responsible for various diseases including cancer. Oxidative stress produces due to the accumulation of free radicals. Free radicals interfere with different process in the body by ...
The amino acid Tyrosine
... groups are occurring in the free form ; they are possessing methyl groups. Mescaline can be synthesized from tyrosine or a hydroxylated phenylalanine,which is decarboxylated to tyramine then followed by oxidation ( ...
... groups are occurring in the free form ; they are possessing methyl groups. Mescaline can be synthesized from tyrosine or a hydroxylated phenylalanine,which is decarboxylated to tyramine then followed by oxidation ( ...
Inhibition of Trypanosoma c ruzi Hexokinase by Bisphosphonates
... since no default Catalyst feature could account for the variety of ring types present in the compounds investigated. CoMSIA analyses were performed by using default settings in the Sybyl 7.0 program.49 Molecular mechanics minimizations using the Tripos force field were carried out in Sybyl 7.049 usi ...
... since no default Catalyst feature could account for the variety of ring types present in the compounds investigated. CoMSIA analyses were performed by using default settings in the Sybyl 7.0 program.49 Molecular mechanics minimizations using the Tripos force field were carried out in Sybyl 7.049 usi ...
Differential induction of hepatic drug
... Moreover, fenvalerate induces microgranulomas in human lymphocytes (Surralles et al., 1995). Fenvalerate was shown to enhance altered hepatic foci and inhibit intercellular communication in vitro (Hemming et al., 1993). Recently, fenvalerate was shown to enhance the activity of hepatic lysosomal enz ...
... Moreover, fenvalerate induces microgranulomas in human lymphocytes (Surralles et al., 1995). Fenvalerate was shown to enhance altered hepatic foci and inhibit intercellular communication in vitro (Hemming et al., 1993). Recently, fenvalerate was shown to enhance the activity of hepatic lysosomal enz ...
Selective phosphodiesterase inhibitors for the treatment
... amounts of other PDE isoenzymes in addition to PDE4 in the target tissues [4,5]. Therefore, just as combined inhibition of PDE3 and PDE4 is more effective than inhibition of a single isoenzyme family in relaxing pre-contracted human airways smooth muscle [6,7], a more effective suppression of inflam ...
... amounts of other PDE isoenzymes in addition to PDE4 in the target tissues [4,5]. Therefore, just as combined inhibition of PDE3 and PDE4 is more effective than inhibition of a single isoenzyme family in relaxing pre-contracted human airways smooth muscle [6,7], a more effective suppression of inflam ...
Antifilarial Lead Molecules Isolated from Trachyspermum ammi
... effective in killing the adult worms, which can live in the host for several years [2] and the treatments are therefore aimed solely at reducing transmission and pathology. Despite the important addition to our knowledge of newer molecules [3-6] with antifilarial activity, none has developed fruitfu ...
... effective in killing the adult worms, which can live in the host for several years [2] and the treatments are therefore aimed solely at reducing transmission and pathology. Despite the important addition to our knowledge of newer molecules [3-6] with antifilarial activity, none has developed fruitfu ...
L3_protein synthesis..
... administration and must be given intramuscularly, or intravenously for systemic effect. Because aminoglycosides are concentration- and timedependent and also have post antibiotic effect, once-daily dosing with the aminoglycosides can be employed. This results in less toxicity and less expensive to ...
... administration and must be given intramuscularly, or intravenously for systemic effect. Because aminoglycosides are concentration- and timedependent and also have post antibiotic effect, once-daily dosing with the aminoglycosides can be employed. This results in less toxicity and less expensive to ...
452صيد
... half life. It has irreversible binding to ATPase H+/K+ Inhibition of acid secretion peaks in 3 to 4 days & lasts for 5 days after discontinuing treatment. They prolong elimination of ...
... half life. It has irreversible binding to ATPase H+/K+ Inhibition of acid secretion peaks in 3 to 4 days & lasts for 5 days after discontinuing treatment. They prolong elimination of ...
Structure-based development of target
... design of focused structure-based libraries by optimizing ligand–receptor complementary interactions, in an attempt to improve potency and/or specificity. The number of high-resolution structures stored in the Protein Databank [14] is rising exponentially year after year and each new structure revea ...
... design of focused structure-based libraries by optimizing ligand–receptor complementary interactions, in an attempt to improve potency and/or specificity. The number of high-resolution structures stored in the Protein Databank [14] is rising exponentially year after year and each new structure revea ...
Pharmacy Newsletter
... 2006 regarding the use of antivirals for the treatment of influenza. For the 2005-2006 season, influenza A (H3N2) viruses isolated from 120 patients in 23 states have been tested at CDC and 109 (91 percent) found to be resistant to amantadine and rimantadine. However, all influenza viruses found acr ...
... 2006 regarding the use of antivirals for the treatment of influenza. For the 2005-2006 season, influenza A (H3N2) viruses isolated from 120 patients in 23 states have been tested at CDC and 109 (91 percent) found to be resistant to amantadine and rimantadine. However, all influenza viruses found acr ...
adrenoceptor agonist sympathomimetics
... platelets binding to fibrinogen and von Willebrand factor, and consequently inhibiting platelet aggregation. It inhibits all the pathways of platelet activation (Final common pathway). ...
... platelets binding to fibrinogen and von Willebrand factor, and consequently inhibiting platelet aggregation. It inhibits all the pathways of platelet activation (Final common pathway). ...
Statins forever: Is anything set to topple this class`s mighty reign?
... There are also a small number of early stage CETPi’s still under active development, including Chong Kun Dang’s Phase I compound, CKD-519, Kowa’s Preclinical K-312 and Dexa Medica’s DLBS1449 (albeit, the only active trial, a Phase II/III, for this compound was recently withdrawn prior to enrolment, ...
... There are also a small number of early stage CETPi’s still under active development, including Chong Kun Dang’s Phase I compound, CKD-519, Kowa’s Preclinical K-312 and Dexa Medica’s DLBS1449 (albeit, the only active trial, a Phase II/III, for this compound was recently withdrawn prior to enrolment, ...
Hyperkalemia Due to Drug Interactions
... tone was added to ACE inhibitors. This was not statistically different from the patients who received placebo instead of spironolactone, so the researchers naturally concluded that hyperkalemia was not a significant problem when spironolactone is combined with ACE inhibitors. When the combination of ...
... tone was added to ACE inhibitors. This was not statistically different from the patients who received placebo instead of spironolactone, so the researchers naturally concluded that hyperkalemia was not a significant problem when spironolactone is combined with ACE inhibitors. When the combination of ...
medicinal - American Chemical Society
... tested with saline selected the saline lever. Based on the 95% confidence intervals, 1 and 2 were of comparable potency, which was significantly greater than the potencies of 3 and 4. The latter two compounds did not have significantly different potencies in substituting for 1. In terms of disruptiv ...
... tested with saline selected the saline lever. Based on the 95% confidence intervals, 1 and 2 were of comparable potency, which was significantly greater than the potencies of 3 and 4. The latter two compounds did not have significantly different potencies in substituting for 1. In terms of disruptiv ...
How to write research & review articles !!!
... (mOzn), thiazoline (Tzn), 3-amino-6-hydroxy-2-piperidone (Ahp) c) With fatty acid acyl chains or even more complex ‘with galactose bridges’ and ‘histidino-tyrosine moiety’. * Proteins (actin, myocin, myoglobulin) are polypeptides in folded form which function as enzymes (Human glyoxalase I), hormone ...
... (mOzn), thiazoline (Tzn), 3-amino-6-hydroxy-2-piperidone (Ahp) c) With fatty acid acyl chains or even more complex ‘with galactose bridges’ and ‘histidino-tyrosine moiety’. * Proteins (actin, myocin, myoglobulin) are polypeptides in folded form which function as enzymes (Human glyoxalase I), hormone ...