Contrast of Medical and Nonmedical Use of Stimulant Drugs, Basis
... networks involved in motivation as well as attention. In stimulantnaive adults with ADHD, we documented deficits (i.e., lower than normal density of the dopamine transporter and lower than normal availability of dopamine D2/3 receptors) in key components of a motivation network (i.e., the nucleus ac ...
... networks involved in motivation as well as attention. In stimulantnaive adults with ADHD, we documented deficits (i.e., lower than normal density of the dopamine transporter and lower than normal availability of dopamine D2/3 receptors) in key components of a motivation network (i.e., the nucleus ac ...
An Analysis of the Generic Pharmaceutical Industries in Brazil and
... patentee. Failing that, the exporter then seeks a compulsory license from its own government on a single-country basis. In addition to demanding technical requirements, compulsory licenses pose a particularly vexing problem by making it difficult to establish a continuous market for a generic drug. ...
... patentee. Failing that, the exporter then seeks a compulsory license from its own government on a single-country basis. In addition to demanding technical requirements, compulsory licenses pose a particularly vexing problem by making it difficult to establish a continuous market for a generic drug. ...
Epinephrine and local anesthesia revisited
... of these drugs (monoamine oxidase (MAO) inhibitors, selective serotonin reuptake inhibitors, and TCAs) along with electroconvulsive shock therapy, regardless of acute biochemical effects, result in the downregulation of CNS beta-adrenergic receptors in a time course that parallels the onset of the a ...
... of these drugs (monoamine oxidase (MAO) inhibitors, selective serotonin reuptake inhibitors, and TCAs) along with electroconvulsive shock therapy, regardless of acute biochemical effects, result in the downregulation of CNS beta-adrenergic receptors in a time course that parallels the onset of the a ...
Paresthesia (including formication) (postmarketing AE), reformating
... The mean elimination half-life is 1 hour shorter for d-amphetamine and 2 hours shorter for l-amphetamine in children aged 6 to 12 years compared to that in adults (t1/2 is 10 hours for d-amphetamine and 13 hours for l-amphetamine in adults, and 9 hours and 11 hours, respectively, for children). Chi ...
... The mean elimination half-life is 1 hour shorter for d-amphetamine and 2 hours shorter for l-amphetamine in children aged 6 to 12 years compared to that in adults (t1/2 is 10 hours for d-amphetamine and 13 hours for l-amphetamine in adults, and 9 hours and 11 hours, respectively, for children). Chi ...
Characteristics and common properties of inhibitors, inducers, and
... of binding to the free enzyme, binds to the enzyme– substrate complex resulting in the formation of a nonproductive enzyme –substrate– inhibitor complex. In this case, both Vmax and Km are decreased proportionately so that the ratio Vmax/Km remains constant. In a Lineweaver –Burk plot of the data, p ...
... of binding to the free enzyme, binds to the enzyme– substrate complex resulting in the formation of a nonproductive enzyme –substrate– inhibitor complex. In this case, both Vmax and Km are decreased proportionately so that the ratio Vmax/Km remains constant. In a Lineweaver –Burk plot of the data, p ...
The impact of polypharmacology on chemical biology Albert Antolín Hernández
... drug promiscuity and with ongoing academic efforts to rationally design multitarget drugs. Drug discovery is, slowly, becoming a more holistic endeavor. Unfortunately, this holistic perspective is not permeating to other disciplines. Since the 1990s, the field of chemical biology has emerged to use ...
... drug promiscuity and with ongoing academic efforts to rationally design multitarget drugs. Drug discovery is, slowly, becoming a more holistic endeavor. Unfortunately, this holistic perspective is not permeating to other disciplines. Since the 1990s, the field of chemical biology has emerged to use ...
HIGHLIGHTS OF PRESCRIBING
... Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw commonly occur after treatment with Sumavel DosePro and are usually non-cardiac in origin. However, perform a cardiac evaluation if these patients are at high cardiac risk. The use of Sumavel DosePro is c ...
... Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw commonly occur after treatment with Sumavel DosePro and are usually non-cardiac in origin. However, perform a cardiac evaluation if these patients are at high cardiac risk. The use of Sumavel DosePro is c ...
Models of intervention and care for psychostimulant users
... Approaches applicable to all psychostimulant users ............................................................66 Polydrug use ...........................................................................................................................................................66 Approaches to e ...
... Approaches applicable to all psychostimulant users ............................................................66 Polydrug use ...........................................................................................................................................................66 Approaches to e ...
Choose the Only FDA-approved Hyaluronidase
... HYLENEX recombinant should not be administered kg. The study found no evidence of teratogenicity. Reduced intravenously. Its effects relative to dispersion and absorption fetal weight and increased numbers of fetal resorptions were of other drugs are not produced when it is administered observed, wi ...
... HYLENEX recombinant should not be administered kg. The study found no evidence of teratogenicity. Reduced intravenously. Its effects relative to dispersion and absorption fetal weight and increased numbers of fetal resorptions were of other drugs are not produced when it is administered observed, wi ...
Gastrointestinal Disorders: Nausea in Adults
... as in the nonpregnant patient. A full assessment is especially appropriate for those pregnant women who first experience nausea and vomiting after the first trimester or have additional symptoms such as pain or fever which do not normally accompany NVP. Management of NVP is similar to that in the no ...
... as in the nonpregnant patient. A full assessment is especially appropriate for those pregnant women who first experience nausea and vomiting after the first trimester or have additional symptoms such as pain or fever which do not normally accompany NVP. Management of NVP is similar to that in the no ...
Pharmacokinetic–pharmacodynamic modelling of the hypothermic
... Briefly, this model is based on the principle of a set-point control in an indirect physiological response model (Dayneka et al., 1993) and is able to characterise quantitatively the effect of 5-HT1A receptor agonists in vivo. In this model, the set-point for maintenance of body temperature is atten ...
... Briefly, this model is based on the principle of a set-point control in an indirect physiological response model (Dayneka et al., 1993) and is able to characterise quantitatively the effect of 5-HT1A receptor agonists in vivo. In this model, the set-point for maintenance of body temperature is atten ...
Models for proconvulsant drugs and precautions for
... VIDEORECORDING is aimed at quantitative and qualitative detection of any convulsant effects in naive rats that may have been missed in others studies. Animals are individually videorecorded in a Phenotyper cage 24h/day (IR camera, Ethovision XT, The Observer) with no limitation in duration. Followin ...
... VIDEORECORDING is aimed at quantitative and qualitative detection of any convulsant effects in naive rats that may have been missed in others studies. Animals are individually videorecorded in a Phenotyper cage 24h/day (IR camera, Ethovision XT, The Observer) with no limitation in duration. Followin ...
Novel Psychoactive Substances
... became ill after consuming a home cooked meal of steak fajitas. • Initial symptoms included tingling in arms and legs, nausea, dizziness, tachycardia, dilated pupils and hallucinations. • The family drove to a nearby hospital where they were admitted. • All victims (including the newborn infant) rec ...
... became ill after consuming a home cooked meal of steak fajitas. • Initial symptoms included tingling in arms and legs, nausea, dizziness, tachycardia, dilated pupils and hallucinations. • The family drove to a nearby hospital where they were admitted. • All victims (including the newborn infant) rec ...
Coca leaf chewing as therapy for cocaine maintenance
... elimination of fatigue, a feeling of euphoria or an antidepressant action was felt within 15 to 20 min. There was also an appearance of increased psycho-motor action, a state of tension typical to alertness, along with an increase in activity or the desire to do something. Sensory functions became m ...
... elimination of fatigue, a feeling of euphoria or an antidepressant action was felt within 15 to 20 min. There was also an appearance of increased psycho-motor action, a state of tension typical to alertness, along with an increase in activity or the desire to do something. Sensory functions became m ...
Aspirin® – an unparalleled “career”
... pharmaceutical research around the world. Building upon more than 200 clinical studies involving more than 200,000 patients on the cardiovascular and pain relief effects of acetylsalicylic acid, researchers in countries around the world continue to explore the potential benefits of aspirin across ot ...
... pharmaceutical research around the world. Building upon more than 200 clinical studies involving more than 200,000 patients on the cardiovascular and pain relief effects of acetylsalicylic acid, researchers in countries around the world continue to explore the potential benefits of aspirin across ot ...
Interactive Association of Drugs Binding to Human
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
Long-acting beta2- adrenoreceptor agonists: salmeterol and
... Formoterol and salmeterol have similar pharmacological properties: both are highly selective and potent beta2-adrenoreceptor agonists, with relaxant effects on bronchial smooth muscle in vitro. However, some significant pharmacological differences between these drugs have been documented in vitro an ...
... Formoterol and salmeterol have similar pharmacological properties: both are highly selective and potent beta2-adrenoreceptor agonists, with relaxant effects on bronchial smooth muscle in vitro. However, some significant pharmacological differences between these drugs have been documented in vitro an ...
Shan Chikhale, Professor of Pharmaceutical Sciences, School of
... preparing medications to meet the unique needs of individual patients. Hence, need for compounding pharmacies and for this industry is growing. Safe, effective, and high-quality extemporaneously compounded (sterile/non-sterile) products is a must! ...
... preparing medications to meet the unique needs of individual patients. Hence, need for compounding pharmacies and for this industry is growing. Safe, effective, and high-quality extemporaneously compounded (sterile/non-sterile) products is a must! ...
Intranasal corticosteroids
... Initiate INCS and stop the offending drug (if caused by nasal decongestant may stop after 3 days of INCS or taper over 1 week to minimize discomfort). 15 Oral decongestants may be used if necessary. In resistant cases, an oral corticosteroid may be required, tapering the dose over 7-10 days. INCS ma ...
... Initiate INCS and stop the offending drug (if caused by nasal decongestant may stop after 3 days of INCS or taper over 1 week to minimize discomfort). 15 Oral decongestants may be used if necessary. In resistant cases, an oral corticosteroid may be required, tapering the dose over 7-10 days. INCS ma ...
Brother Can You Spare a Drug - Scholarly Commons at Hofstra Law
... are infected with the HIV virus and whose immune system cells have been depleted, but who show few or no AIDS symptoms. See Hilts, AIDS Drug's Maker Cuts Price By 20%, N.Y. Times, Sept. 19, 1989, at Al, col. 1. Furthermore, studies have shown that AZT is often intolerable by patients with AIDS due t ...
... are infected with the HIV virus and whose immune system cells have been depleted, but who show few or no AIDS symptoms. See Hilts, AIDS Drug's Maker Cuts Price By 20%, N.Y. Times, Sept. 19, 1989, at Al, col. 1. Furthermore, studies have shown that AZT is often intolerable by patients with AIDS due t ...
PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST ASPIRIN INDUCED GASTRIC DAMAGE IN RATS Original Article
... Methods: Ethanolic and aqueous extracts of Nigella sativa were prepared with the help of Soxhlet’s apparatus. Forty two wistar albino rats (150200g) of either sex were divided into seven groups of 6 each. Rats of group I and II were administered distilled water 0.5ml daily p.o for 5days, Group III w ...
... Methods: Ethanolic and aqueous extracts of Nigella sativa were prepared with the help of Soxhlet’s apparatus. Forty two wistar albino rats (150200g) of either sex were divided into seven groups of 6 each. Rats of group I and II were administered distilled water 0.5ml daily p.o for 5days, Group III w ...
Beta Blocker Newsletter
... the kidney. They have less effect on â2 receptors found in pulmonary and vascular smooth muscle and the pancreas. Cardioselective agents should theoretically cause less coldness of the extremities and less bronchospasm. Unfortunately, selectivity is dose-dependent and varies widely among patients1 s ...
... the kidney. They have less effect on â2 receptors found in pulmonary and vascular smooth muscle and the pancreas. Cardioselective agents should theoretically cause less coldness of the extremities and less bronchospasm. Unfortunately, selectivity is dose-dependent and varies widely among patients1 s ...
PDF, 288KB - Queensland Courts
... 34. Her statement indicated the initial contact regarding Will was from his mother Margaret who telephoned Dr Tait stating he was in pain and was suffering from swelling following the removal of wisdom teeth. 35. Will himself phoned Dr Tait at about 6:40pm on Friday 17 June. He told Dr Tait he was t ...
... 34. Her statement indicated the initial contact regarding Will was from his mother Margaret who telephoned Dr Tait stating he was in pain and was suffering from swelling following the removal of wisdom teeth. 35. Will himself phoned Dr Tait at about 6:40pm on Friday 17 June. He told Dr Tait he was t ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.