GHB
... GHB analogs - What does it do • At lower doses, GHB has sedative effects, but, as the dose increases, GHB effects may result in sleep ,eventual coma, respiratory arrest, or death. • It is these effects that make it both a prime drug at Raves, and for Date Rape ...
... GHB analogs - What does it do • At lower doses, GHB has sedative effects, but, as the dose increases, GHB effects may result in sleep ,eventual coma, respiratory arrest, or death. • It is these effects that make it both a prime drug at Raves, and for Date Rape ...
POLIGUGUL COMPLEX
... While reducing dietary cholesterol may be helpful, not all cholesterol comes from dietary sources. The body also produces cholesterol. Policosanol, a mixture of long chain, high molecular weight alcohols isolated from sugar cane, helps reduce cholesterol levels by inhibiting its synthesis within the ...
... While reducing dietary cholesterol may be helpful, not all cholesterol comes from dietary sources. The body also produces cholesterol. Policosanol, a mixture of long chain, high molecular weight alcohols isolated from sugar cane, helps reduce cholesterol levels by inhibiting its synthesis within the ...
Tramadol Hydrochloride ER
... in the liver by the enzyme cytochrome P450 (CYP) 2D6 to its active form to provide pain relief. Approximately 7% of the population does not have the enzyme and cannot convert tramadol hydrochloride to its active form, leading to lack of benefit. Another 10% of patients have excessive enzyme and conv ...
... in the liver by the enzyme cytochrome P450 (CYP) 2D6 to its active form to provide pain relief. Approximately 7% of the population does not have the enzyme and cannot convert tramadol hydrochloride to its active form, leading to lack of benefit. Another 10% of patients have excessive enzyme and conv ...
NSAIDS Use of OTCs last updated 07/10
... recommendation of over-the-counter NSAIDs. However, patients may be referred for prescription drug therapy when appropriate. Many low-dose NSAIDs are available over the counter, but higher potency forms require a prescription. Co-management with a practitioner having access to prescription NSAIDs ma ...
... recommendation of over-the-counter NSAIDs. However, patients may be referred for prescription drug therapy when appropriate. Many low-dose NSAIDs are available over the counter, but higher potency forms require a prescription. Co-management with a practitioner having access to prescription NSAIDs ma ...
PDF - Journal of Applied Pharmaceutical Science
... plant, typically Mediterranean, largely used in folk medicine in the Mediterranean countries including Algeria. The aim of the present research is to assess the in vitro effects of aqueous extract of different parts of Capparis spinosa (leaves, fruits and seeds) on rat trachea in order to establish ...
... plant, typically Mediterranean, largely used in folk medicine in the Mediterranean countries including Algeria. The aim of the present research is to assess the in vitro effects of aqueous extract of different parts of Capparis spinosa (leaves, fruits and seeds) on rat trachea in order to establish ...
P-RMS
... hepatic insufficiency. The contraindications and precautions should be carefully observed and close monitoring, particularly of heart rate, should be carried out at the beginning of treatment. Calcium channel blocking agents, such as diltiazem, may be associated with mood changes, including depressi ...
... hepatic insufficiency. The contraindications and precautions should be carefully observed and close monitoring, particularly of heart rate, should be carried out at the beginning of treatment. Calcium channel blocking agents, such as diltiazem, may be associated with mood changes, including depressi ...
drugs used in migraine
... Signs and symptoms • The signs and symptoms of migraine vary among patients. Therefore, what a patient experiences before, during and after an attack cannot be defined exactly. The four phases of a migraine attack listed below are common but not necessarily experienced by all migraine sufferers. Ad ...
... Signs and symptoms • The signs and symptoms of migraine vary among patients. Therefore, what a patient experiences before, during and after an attack cannot be defined exactly. The four phases of a migraine attack listed below are common but not necessarily experienced by all migraine sufferers. Ad ...
Prophylactic Antiarrhythmic Drug Therapy in Atrial Fibrillation
... the sodium–potassium pump, the time constants of binding to cellular sites, effects on second messengers, and the affinity for binding on the basis of whether the cell is in an active or inactive state.3 This result in a tabular list of virtually everything that makes it more complex, and although c ...
... the sodium–potassium pump, the time constants of binding to cellular sites, effects on second messengers, and the affinity for binding on the basis of whether the cell is in an active or inactive state.3 This result in a tabular list of virtually everything that makes it more complex, and although c ...
Should Per Se Limits Be Imposed For Cannabis?
... Cannabis’ maximum influence on performance typically manifests in subjects some 20 to 40 minutes following inhalation (Sewell et al., 2009), during a time period when the subject’s THC/blood levels are rapidly falling. The substance’s influence on behavior then diminishes relatively rapidly some 60 ...
... Cannabis’ maximum influence on performance typically manifests in subjects some 20 to 40 minutes following inhalation (Sewell et al., 2009), during a time period when the subject’s THC/blood levels are rapidly falling. The substance’s influence on behavior then diminishes relatively rapidly some 60 ...
Anti-inflammatory, Antinociceptive, Antipyretic and
... with C.comosum extract showed a dose-dependent reduction in pyrexia in rats and suppressed the ethanol-induced gastric lesions. The present results suggest that C. comosum possessed anti-inflammatory, anti-nociceptive, and antipyretic activities. Besides, the herb showed protective effect against et ...
... with C.comosum extract showed a dose-dependent reduction in pyrexia in rats and suppressed the ethanol-induced gastric lesions. The present results suggest that C. comosum possessed anti-inflammatory, anti-nociceptive, and antipyretic activities. Besides, the herb showed protective effect against et ...
On the Upper Bound of the Information Capacity in Neuronal
... The knowledge about the neuronal anatomy, physiology, and the manner in which information is processed and communicated at various stages in single neurons has accumulated [6], [7], [16]. The main neuronal compartments with two possible configurations forming the concepts of bipartite and tripartite ...
... The knowledge about the neuronal anatomy, physiology, and the manner in which information is processed and communicated at various stages in single neurons has accumulated [6], [7], [16]. The main neuronal compartments with two possible configurations forming the concepts of bipartite and tripartite ...
Suggestion from clinicians
... rizatriptan, sumatriptan and zolmitriptan. All act on serotonin (5-HT) subclass 1B and 1D receptors, on extracerebral blood vessels and neurons respectively. The supposed mechanism of action is prevention of neurogenically sterile inflammatory responses around vessels and vasoconstriction. The newer ...
... rizatriptan, sumatriptan and zolmitriptan. All act on serotonin (5-HT) subclass 1B and 1D receptors, on extracerebral blood vessels and neurons respectively. The supposed mechanism of action is prevention of neurogenically sterile inflammatory responses around vessels and vasoconstriction. The newer ...
Two simple animal models of intraocular pressure elevation for testing
... pressure (IOP) is one of the most important risk factors. There are many experimental models to test the effect of new drugs but they are often expensive or require invasive techniques. The purpose of this poster is to present two simple animal models of intraocular pressure elevation for testing th ...
... pressure (IOP) is one of the most important risk factors. There are many experimental models to test the effect of new drugs but they are often expensive or require invasive techniques. The purpose of this poster is to present two simple animal models of intraocular pressure elevation for testing th ...
Indole alkaloids
... • is the dried whole plant of catharanthus roseus. F. Apocynaceae. • Folklore uses as an oral hypoglycemic agent. • It contain 150 alkaloids, the most important are the anticancer agents vincristine and vinblastine. • These are complex bisindole (dimeric indole) natural products present in small qua ...
... • is the dried whole plant of catharanthus roseus. F. Apocynaceae. • Folklore uses as an oral hypoglycemic agent. • It contain 150 alkaloids, the most important are the anticancer agents vincristine and vinblastine. • These are complex bisindole (dimeric indole) natural products present in small qua ...
Clinical Pharmacy Department Clinical Pharmacy Modul 3
... A. aluminum hydroxide B. sodium bicarbonate C. calcium carbonate D. all of the above E. aluminum hydroxide and calcium carbonate ANSWER: E Which of the following substances has its major activity as an stimulant cathartic? A. sodium bicarbonate B. methylcellulose C. sodium citrate D. castor oil E. m ...
... A. aluminum hydroxide B. sodium bicarbonate C. calcium carbonate D. all of the above E. aluminum hydroxide and calcium carbonate ANSWER: E Which of the following substances has its major activity as an stimulant cathartic? A. sodium bicarbonate B. methylcellulose C. sodium citrate D. castor oil E. m ...
A theory of drug tolerance and dependence I
... deal with the disturbance as effectively as possible in the given circumstances. The organism’s learning process during adaptation in response to the repeated administration of a drug inevitably presumes memory over an extended period of time: memory for the properties of the particular drug, memory ...
... deal with the disturbance as effectively as possible in the given circumstances. The organism’s learning process during adaptation in response to the repeated administration of a drug inevitably presumes memory over an extended period of time: memory for the properties of the particular drug, memory ...
Non-malignant Chronic Pain - Derbyshire Medicines Management
... Criteria for referral to Pain Management Programme (North Derbyshire and Hardwick CCGs) For adults (18+) who are experiencing difficulties with pain and who would be interested in engaging with an educational group approach, the programme combines explaining the physiological and psychological mecha ...
... Criteria for referral to Pain Management Programme (North Derbyshire and Hardwick CCGs) For adults (18+) who are experiencing difficulties with pain and who would be interested in engaging with an educational group approach, the programme combines explaining the physiological and psychological mecha ...
Should we be concerned about herbal remedies
... particularly India, for patients to seek concurrent treatment through more than one Indian Medicinal System as well as allopathy, or in Chinese herbalism to fraudulently incorporate pharmaceuticals in some remedies. This only compounds issues related to recognizing the source of potential side effec ...
... particularly India, for patients to seek concurrent treatment through more than one Indian Medicinal System as well as allopathy, or in Chinese herbalism to fraudulently incorporate pharmaceuticals in some remedies. This only compounds issues related to recognizing the source of potential side effec ...
Quetiapine and sleep apnoea syndrome Introduction Reports
... antipsychotics and is indicated for the treatment of schizophrenia. It is also indicated for the acute treatment of manic and depressive episodes associated with bipolar disorder and the maintenance treatment of bipolar disorder. Quetiapine is an antagonist at multiple neurotransmitter receptors in ...
... antipsychotics and is indicated for the treatment of schizophrenia. It is also indicated for the acute treatment of manic and depressive episodes associated with bipolar disorder and the maintenance treatment of bipolar disorder. Quetiapine is an antagonist at multiple neurotransmitter receptors in ...
Drug Development Pipeline
... or may be living entities such as cells and tissues. Biologics are isolated from a variety of natural sources - human, animal, or microorganism - and may be produced by biotechnology methods and other cutting-edge technologies. Gene-based and cellular biologics, for example, often are at the forefro ...
... or may be living entities such as cells and tissues. Biologics are isolated from a variety of natural sources - human, animal, or microorganism - and may be produced by biotechnology methods and other cutting-edge technologies. Gene-based and cellular biologics, for example, often are at the forefro ...
presentation source
... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
Ocular Pain Management for Primary Care OD
... right eye” yesterday. He is a mechanic. He was working underneath a car and something, “maybe rust” fell into his eyes while he was working. It has happened several times before. +pain 2-3 out of 5 on the severity scale, +mild watering, no photophobia, no discharge, +redness, +mild blur to vision. P ...
... right eye” yesterday. He is a mechanic. He was working underneath a car and something, “maybe rust” fell into his eyes while he was working. It has happened several times before. +pain 2-3 out of 5 on the severity scale, +mild watering, no photophobia, no discharge, +redness, +mild blur to vision. P ...
DEMEROL (meperidine hydrochloride
... drugs). Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. Screen patients for risk of substance use disorders, including opioid abuse and misuse, and warn them of the risk for overdose and ...
... drugs). Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. Screen patients for risk of substance use disorders, including opioid abuse and misuse, and warn them of the risk for overdose and ...
Management of Grapefruit-Drug Interactions
... The characteristics of medications that interact with grapefruit are well defined. The most significant of these characteristics is metabolism by the intestinal cytochrome P450 3A4 (CYP 3A4) system. CYP 3A4 is found in the liver and intestinal tract. Intestinal CYP 3A4 concentration can be decreased ...
... The characteristics of medications that interact with grapefruit are well defined. The most significant of these characteristics is metabolism by the intestinal cytochrome P450 3A4 (CYP 3A4) system. CYP 3A4 is found in the liver and intestinal tract. Intestinal CYP 3A4 concentration can be decreased ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.