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Antidiarrheal activity of methanol leaf extract of Lophira Lanceolata
Antidiarrheal activity of methanol leaf extract of Lophira Lanceolata

... This study investigated the effect of methanol leaf extract of Lophira lanceolata for antidiarrheal and spasmolytic properties in experimental albino Wistar rats. The methanol extract (ME) obtained by 72 h maceration was evaluated for antidiarrheal activity using Castor oil induced diarrhea, GIT tra ...
How FDA Approves Drugs and Regulates Their Safety and
How FDA Approves Drugs and Regulates Their Safety and

- Obstetrics & Gynecology Clinics of North America
- Obstetrics & Gynecology Clinics of North America

... and to determine when to start therapy, based primarily on observations from opioid withdrawal.44 The most commonly used scale in the United States is the modified Finnegan Neonatal Abstinence Scoring system (Fig. 1).7,45 This comprehensive tool is completed every 4 to 6 hours with items covering ce ...
ZOLOFT DATA SHEET PRESENTATION ®
ZOLOFT DATA SHEET PRESENTATION ®

... antidepressant medications, and this risk may persist until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored for clinical worsening and suicidality, especially at the beginning of a course of treatment, o ...
Ibuprofen is a non-steriodal anti-inflammatory drug with established
Ibuprofen is a non-steriodal anti-inflammatory drug with established

... comparator and placebo-controlled studies. The comparator most frequently used is paracetamol. Licensed doses of ibuprofen vary between countries, as they do for paracetamol. For all licensed doses, ibuprofen has been shown to be at least as effective as paracetamol in treating fever. There is evide ...
Formulation Development of Chlorpheniramine Maleate Tablet by
Formulation Development of Chlorpheniramine Maleate Tablet by

... administering the drug, attention must be paid to their design, development and manufacturing technique in order to get the correct medicinal benefits. This directly compressible formulation was compared with three leading marketed brands for efficiency and competence. These marketed brands are manu ...
In vivo and in vitro studies on drug metabolism and
In vivo and in vitro studies on drug metabolism and

... endogenous biochemicals (Gonzalez 1992). The phase II transferases serve to transfer various water-soluble molecules such as glucuronic acid, sulfonic acid and glutathione to other chemicals (Gonzalez & Idle 1994). Often, drugs undergo both phase I and phase II reactions sequentially, but excretion ...
The Effects of Caffeine on the Human Metabolism
The Effects of Caffeine on the Human Metabolism

... receptors and the effect of adenosine receptors on the human metabolism (Cano-Marquina 8). Any change in metabolism should be carefully considered because it affects the entire human body. An experiment was designed to measure the effects that caffeine has on the time it takes to complete an exerci ...
Effect of cranberry dietary supplements with
Effect of cranberry dietary supplements with

... The use of dietary supplements has increased dramatically, making drug interactions with those supplements a major concern. Because dietary supplements are not subject to the same regulations as prescription drugs, we hypothesize that the content of their active ingredients may vary among manufactur ...
Ketamine - thblack.com
Ketamine - thblack.com

... David, H., & Shipp, Joseph, J. (2010). A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Annals of Emergency Medicine, 57(5); 435-441. Fuchs-Buder, T., Wilder-Smith, O., Borgeat, A., & Tassonyi, E. (1995). Interaction of magnesium ...
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... Watch out for long-acting chronic pain meds As I said earlier, the most powerful pain relievers in the world of all come from the opium poppy (Papaver somniferum). And today, an estimated 4.3 million Americans use opioids on a daily basis for pain. If you use one—such as Oxycontin or Vicodin—there’s ...
Drug therapy in autism: a present and future perspective
Drug therapy in autism: a present and future perspective

... of the general population [20]. Autism is traditionally considered a “static” encephalopathic disorder without any specific cure and few effective biomedical interventions [91]. ...
Trental (pentoxifylline)
Trental (pentoxifylline)

... Antihypertensive agents: Trental (pentoxifylline) may potentiate the action of antihypertensive agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents. Anticoagulants: There have been reports of bleeding and/or prolonged ...
Drug List
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... ONLY Medications that are included by name and dose in the 2012 NCCEP Protocols are included in this document; the only purpose of this document is to serve as a reference for the 2012 NCCEP Protocols. For a full list of medications approved for use by EMS professionals, please refer to the North Ca ...
New horizons in pulmonary arterial hypertension therapies
New horizons in pulmonary arterial hypertension therapies

... well tolerated by the patients in this trial and, notably, adverse events commonly associated with the ERA drug class (elevated liver aminotransferases and peripheral oedema) occurred at a similar rate to patients who received placebo across all groups [27]. Macitentan has recently been approved by ...
DRUG NAME: Octreotide  SYNONYM(S): COMMON TRADE NAME(S):
DRUG NAME: Octreotide SYNONYM(S): COMMON TRADE NAME(S):

... later trimesters.5 Breastfeeding: Although octreotide is likely digested when taken orally,5 breastfeeding should be avoided unless ...
Why test for Hydrocodone and Hydromorphone?
Why test for Hydrocodone and Hydromorphone?

... Hydrocodone is one of the most misused prescription drugs on the market, according to the Drug Enforcement Administration (1). It is a semi-synthetic opioid, most commonly known as Vicodin® and is prescribed as a cough suppressant and for the treatment of moderate to severe pain. One of its metaboli ...
SYMBYAX®
SYMBYAX®

... increase in the mean maximum concentration of olanzapine (16%) following a 5-mg dose, an increase in the mean area under the curve (17%) and a small decrease in mean apparent clearance of olanzapine (16%). In another study, a similar decrease in apparent clearance of olanzapine of 14% was observed f ...
274   Antibacterials
274 Antibacterials

... and green-red colour blindness. One or both eyes may be affected. The degree of visual impairment appears to depend on the dose and duration of therapy; toxicity is observed most frequently at daily doses of 25 mg/kg or more and after at least 2 months of therapy. Recovery of vision usually takes pl ...
effects of antihypertensive drugs on carotid intima
effects of antihypertensive drugs on carotid intima

... 4,662 patients); 3) angiotensin-II receptor blockers (ARBs) versus other antihypertensive agents (six trials including 841 patients). Our main findings can be summarized as follows: I) Long-term antihypertensive treatment has a blunting effect on carotid IMT progression, regardless of types of drugs ...
Evaluation of reward from pain relief
Evaluation of reward from pain relief

... Therefore, ongoing postsurgical pain reflected by guarding and CPP is likely to be driven by spontaneous nociceptor activity. This may explain why ongoing pain may resolve at an earlier time after injury, while evoked pain still persists. This conclusion is in agreement with clinical observations of ...
The use of injectable nonsteroidal anti
The use of injectable nonsteroidal anti

... useful analgesics for musculoskeletal or joint pain, soft tissue injury, acute gout, headache, post-operative pain, dysmenorrhoea, renal and even biliary colic. Efficacy among NSAID is comparable or even better than narcotic analgesics. 1-7 In contrast to narcotic analgesics, NSAID do not cause resp ...
Differential Influences of Ethanol on Early Exposure to Racemic
Differential Influences of Ethanol on Early Exposure to Racemic

... concentration (Tmax) occurred 1.1 hours earlier than in women, consistent with an increased rate of d-MPH absorption reducing hepatic extraction. More rapid absorption of d-MPH carries implications for increased abuse liability. ...
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Psychopharmacology



Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.
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