Chemotherapy-Induced Nausea and Vomiting
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
A Review Of Research Into The Impacts Of Alcohol Warning Labels
... and warning labels. They conclude that warning labels have the potential to influence behaviour but this depends on their design, the content of the messages, and how well they are targeted at their intended audience. Babor et al (2003) conducted a systematic review of the evidence for a variety of ...
... and warning labels. They conclude that warning labels have the potential to influence behaviour but this depends on their design, the content of the messages, and how well they are targeted at their intended audience. Babor et al (2003) conducted a systematic review of the evidence for a variety of ...
A New Look at the 5α-Reductase Inhibitor Finasteride
... Treatment with finasteride produces a rapid reduction in serum DHT concentration from 60 to 80% (18,116,117), which demonstrates the contribution of the human Type I enzyme to serum DHT levels. However, finasteride decreases prostatic DHT concentrations (where the Type II enzyme predominates) by as ...
... Treatment with finasteride produces a rapid reduction in serum DHT concentration from 60 to 80% (18,116,117), which demonstrates the contribution of the human Type I enzyme to serum DHT levels. However, finasteride decreases prostatic DHT concentrations (where the Type II enzyme predominates) by as ...
Author`s personal copy
... systems are planned to be used with different drugs. However, there are several strategies to modulate drug solubility, e.g. the use of solubilizers described in detail elsewhere [2]. Two compartment osmotic pumps (Fig. 1C) store drug formulation and osmotic agent in two separate compartments. Durin ...
... systems are planned to be used with different drugs. However, there are several strategies to modulate drug solubility, e.g. the use of solubilizers described in detail elsewhere [2]. Two compartment osmotic pumps (Fig. 1C) store drug formulation and osmotic agent in two separate compartments. Durin ...
Document
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
O v e r d o s e and Response
... first occur and opportunities for intervention are the greatest. I am a co-founder and the current director of the Chicago Recovery Alliance, a harm reduction organization that provides comprehensive services to drug users in the Chicago area, including distributing 35,000 syringes per week. I, too, ...
... first occur and opportunities for intervention are the greatest. I am a co-founder and the current director of the Chicago Recovery Alliance, a harm reduction organization that provides comprehensive services to drug users in the Chicago area, including distributing 35,000 syringes per week. I, too, ...
Impact of Ignoring Extraction Ratio When Predicting Drug
... The concept of hepatic clearance has been described by either a well stirred or a parallel tube model (Rowland et al., 1973; Pang and Rowland, 1977). Through many iterations (Ito et al., 1998; Mayhew et al., 2000; Ernest et al., 2005; Venkatakrishnan and Obach, 2005; Obach et al., 2006; Shou et al., ...
... The concept of hepatic clearance has been described by either a well stirred or a parallel tube model (Rowland et al., 1973; Pang and Rowland, 1977). Through many iterations (Ito et al., 1998; Mayhew et al., 2000; Ernest et al., 2005; Venkatakrishnan and Obach, 2005; Obach et al., 2006; Shou et al., ...
19 Improving the Oral Absorption of S-SEDDS Formulations
... SEDDS and S-SEDDS are self-emulsifying formulations of poorly soluble drugs that contain both a surfactant and lipid, along with a co-solvent, and they are usually formulated in gelatin capsules. Dilution of SEDDS or S-SEDDS formulations with water results in the generation of a microemulsion with a ...
... SEDDS and S-SEDDS are self-emulsifying formulations of poorly soluble drugs that contain both a surfactant and lipid, along with a co-solvent, and they are usually formulated in gelatin capsules. Dilution of SEDDS or S-SEDDS formulations with water results in the generation of a microemulsion with a ...
Woolley et al - University of California, San Francisco
... The nucleus accumbens (NAcc) is a critical site for opioid regulation of palatability. Microinjection of D-Ala2,N,MePhe4,Gly-ol5-enkephalin (DAMGO) (a opioid (MOP) receptor selective agonist) into the NAcc selectively increases consumption of calorie dense (sucrose and lard (Zhang et al., 1998)) a ...
... The nucleus accumbens (NAcc) is a critical site for opioid regulation of palatability. Microinjection of D-Ala2,N,MePhe4,Gly-ol5-enkephalin (DAMGO) (a opioid (MOP) receptor selective agonist) into the NAcc selectively increases consumption of calorie dense (sucrose and lard (Zhang et al., 1998)) a ...
View eBook - Absorption Systems
... specific pharmacologic reagents and assay systems. Nearly all available transporter probe substrates and inhibitors interact with multiple transporters. Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enz ...
... specific pharmacologic reagents and assay systems. Nearly all available transporter probe substrates and inhibitors interact with multiple transporters. Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enz ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Reduction of intraocular pressure and causes mydriasis (pupil dilation): treatment of openangle glaucoma or 2 receptors, or both – Examples: epinephrine and dipivefrin ...
... Reduction of intraocular pressure and causes mydriasis (pupil dilation): treatment of openangle glaucoma or 2 receptors, or both – Examples: epinephrine and dipivefrin ...
Dear Sir/Madam - University of Michigan College of Pharmacy
... Development of New Medicine IND, IB, NDA, MAA filing, IB preparation, and product registration: o Pregabalin (Lyrica, CI-1008) and backups (CI-1045, PD 299685, etc.) o Gabapentin (Neurontin, CI-945) o Gabapentin and naproxen combination (CI-1032) o Antiobesity project: Cobalt mesoporpherin (PD 160 ...
... Development of New Medicine IND, IB, NDA, MAA filing, IB preparation, and product registration: o Pregabalin (Lyrica, CI-1008) and backups (CI-1045, PD 299685, etc.) o Gabapentin (Neurontin, CI-945) o Gabapentin and naproxen combination (CI-1032) o Antiobesity project: Cobalt mesoporpherin (PD 160 ...
Baclofen Intoxication
... Baclofen toxicity is a clinical diagnosis; measuring plasma levels is not always possible, and results can be misleading. The half-life is 3.5 hours in therapeutic use but a serum half-life of up to 34 hours has been estimated after overdose. Animal experiments with radiolabeled baclofen indicate th ...
... Baclofen toxicity is a clinical diagnosis; measuring plasma levels is not always possible, and results can be misleading. The half-life is 3.5 hours in therapeutic use but a serum half-life of up to 34 hours has been estimated after overdose. Animal experiments with radiolabeled baclofen indicate th ...
Dexedrine/Dexedrine Spansules (dextroamphetamine)
... Adverse Reactions and Precautions Dexedrine has a high potential for abuse. Individuals with a history of alcohol and substance abuse may be at risk for abusing stimulants. Individuals who abuse Dexedrine develop tolerance and psychological dependence that may result in addiction. With long-term abu ...
... Adverse Reactions and Precautions Dexedrine has a high potential for abuse. Individuals with a history of alcohol and substance abuse may be at risk for abusing stimulants. Individuals who abuse Dexedrine develop tolerance and psychological dependence that may result in addiction. With long-term abu ...
Product Monograph Template - Standard
... Symptoms of overdose are mostly of a sympathomimetic nature. Symptoms may vary from CNS depression (sedation, apnoea, diminished mental alertness, cyanosis, coma, cardiovascular collapse) to CNS stimulation (insomnia, hallucination, tremors, convulsions) with possible fatal outcome. Other symptoms m ...
... Symptoms of overdose are mostly of a sympathomimetic nature. Symptoms may vary from CNS depression (sedation, apnoea, diminished mental alertness, cyanosis, coma, cardiovascular collapse) to CNS stimulation (insomnia, hallucination, tremors, convulsions) with possible fatal outcome. Other symptoms m ...
Dear Dr Neurologist - Fluoroquinolone Toxicity of the Thyroid
... . . ciprofloxacine shows inhibiting properties at the GABAa-receptor and leads to an up regulation of glutamatergic neurotransmission. Other drugs, which act via up regulation of glutamatergic neurotransmission, are NMDAantagonists like ketamine or phenycyclidine, which cause a so-called model-psych ...
... . . ciprofloxacine shows inhibiting properties at the GABAa-receptor and leads to an up regulation of glutamatergic neurotransmission. Other drugs, which act via up regulation of glutamatergic neurotransmission, are NMDAantagonists like ketamine or phenycyclidine, which cause a so-called model-psych ...
Anti-Vascular Endothelial Growth Factor Drugs for the
... in several different retinal conditions. This evidence was included in the Science Report and, in addition, a targeted review of safety data regarding intravitreal use of bevacizumab was carried out and included in the Science Report to assess the potential harms associated with the use of bevacizum ...
... in several different retinal conditions. This evidence was included in the Science Report and, in addition, a targeted review of safety data regarding intravitreal use of bevacizumab was carried out and included in the Science Report to assess the potential harms associated with the use of bevacizum ...
literature review ii
... enhanced the release rate of propranolol hydrochloride, however the dibasic calcium phosphate (DCP) demonstrated slower release rate. The prepared sustained release matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, in vi ...
... enhanced the release rate of propranolol hydrochloride, however the dibasic calcium phosphate (DCP) demonstrated slower release rate. The prepared sustained release matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, in vi ...
T3 Not 4 Me
... New opioid gets started too high – converted at “equianalgesic dose” – but codeine wasn’t getting converted before ...
... New opioid gets started too high – converted at “equianalgesic dose” – but codeine wasn’t getting converted before ...
FDA Approved Labeling 12.19.08 3pm NovaDel Pharma Inc.
... In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides), has been reported in association with the use of sedativehypnotics. It can rarely be determined with certainty whether a particular instance of the abnormal behaviors lis ...
... In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides), has been reported in association with the use of sedativehypnotics. It can rarely be determined with certainty whether a particular instance of the abnormal behaviors lis ...
... since opium was one of the few efficient drugs available to the medical community before the event of modern medicine. In 1805 the young German pharmacist Friedrich Sertürner published his studies on opium, where he discovered an acid that he called `Opium-Saüre´ or meconic acid, but also an alkalin ...
Oral L-glutamine increases GABA levels in
... A number of neurotransmitters exhibit the property of having their rates of synthesis and/or release depend primarily on brain levels of their amino acid precursors (1). Thus, tyrosine levels can control catecholamine synthesis in and release from neurons that are firing frequently (2, 3); serotonin ...
... A number of neurotransmitters exhibit the property of having their rates of synthesis and/or release depend primarily on brain levels of their amino acid precursors (1). Thus, tyrosine levels can control catecholamine synthesis in and release from neurons that are firing frequently (2, 3); serotonin ...
Evaluation of Diuretic activities of hydro
... body salt and fluid balance and blood pressure homeostasis through the actions of their nephrons (Zhuo and Li, 2013). Nephrons are the structural and functional units of the kidneys. Each kidney contains over one million of these tiny blood processing units, which carry out the processes that form u ...
... body salt and fluid balance and blood pressure homeostasis through the actions of their nephrons (Zhuo and Li, 2013). Nephrons are the structural and functional units of the kidneys. Each kidney contains over one million of these tiny blood processing units, which carry out the processes that form u ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.