PRODUCT MONOGRAPH METADOL
... administration of METADOL and there is a potential for development of psychological dependence. Physical dependence and tolerance reflect the neuroadaptation of the opiate receptors to chronic exposure to an opiate, and are separate and distinct from abuse and addiction. Tolerance, as well as physic ...
... administration of METADOL and there is a potential for development of psychological dependence. Physical dependence and tolerance reflect the neuroadaptation of the opiate receptors to chronic exposure to an opiate, and are separate and distinct from abuse and addiction. Tolerance, as well as physic ...
Bipolar Disorders and Lithium: Pharmacokinetics
... and have anti-manic properties by modulating glutamate levels. It is proposed that lithium competes with magnesium for binding to NMDA glutamate receptor, increasing the availability of glutamate in postsynaptic neurons. The NMDA receptor is also affected by other neurotransmitters such as serotonin ...
... and have anti-manic properties by modulating glutamate levels. It is proposed that lithium competes with magnesium for binding to NMDA glutamate receptor, increasing the availability of glutamate in postsynaptic neurons. The NMDA receptor is also affected by other neurotransmitters such as serotonin ...
Medication and Smoking Cessation
... Summary of Product Characteristics Exelon. Novartis Pharmaceuticals UK Ltd. Accessed via www.medicines.org.uk/emc/ [date of revision of the text 20/4/2012]. Summary of Product Characteristics Fendrix. GlaxoSmithKline UK Ltd. Accessed via www.medicines.org.uk/emc/ [date of revision of the text 19/12/ ...
... Summary of Product Characteristics Exelon. Novartis Pharmaceuticals UK Ltd. Accessed via www.medicines.org.uk/emc/ [date of revision of the text 20/4/2012]. Summary of Product Characteristics Fendrix. GlaxoSmithKline UK Ltd. Accessed via www.medicines.org.uk/emc/ [date of revision of the text 19/12/ ...
Paroxetine
... contract to tricyclic antidepressants, paroxetine has little affinity for alpha1-, alpha2- and betaadrenoreceptors, dopamine (D2), 5-HT1 -like, 5-HT2 and histamine (H1) receptors. This lack of interaction with postsynaptic receptors in vitro is substantiated by in vivo studies that demonstrate a lac ...
... contract to tricyclic antidepressants, paroxetine has little affinity for alpha1-, alpha2- and betaadrenoreceptors, dopamine (D2), 5-HT1 -like, 5-HT2 and histamine (H1) receptors. This lack of interaction with postsynaptic receptors in vitro is substantiated by in vivo studies that demonstrate a lac ...
Assessment report on Vitex agnus-castus L., fructus
... Vitex agnus-castus, which grows in the region of the Mediterranean Sea, is a shrub which belongs to the Verbenaceae plant family. The medicinal plant was already mentioned by Dioscurides, a famous pharmacologist of the antiquity. “Agnós” as well as “castus” means “chaste”. The plant, respectively it ...
... Vitex agnus-castus, which grows in the region of the Mediterranean Sea, is a shrub which belongs to the Verbenaceae plant family. The medicinal plant was already mentioned by Dioscurides, a famous pharmacologist of the antiquity. “Agnós” as well as “castus” means “chaste”. The plant, respectively it ...
Herbal Medicines
... – How the herb is prepared has the greatest influence upon the pharmacological and toxicological actions in the body – Herbs can become contaminated if handled improperly – Herbs can become contaminated if grown improperly ...
... – How the herb is prepared has the greatest influence upon the pharmacological and toxicological actions in the body – Herbs can become contaminated if handled improperly – Herbs can become contaminated if grown improperly ...
uniformity (a required drug dose). This led to the develop-
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
alertec - Shire Canada
... ALERTEC required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). The differential was slightly larger when only studies on OSA were included, with 3.4% of patients on ALERTEC and 1.1% of patients on placebo requiring such alterations in the use of ...
... ALERTEC required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). The differential was slightly larger when only studies on OSA were included, with 3.4% of patients on ALERTEC and 1.1% of patients on placebo requiring such alterations in the use of ...
A randomized, double-blind, placebo
... are limited and surgery may lead to permanent numbness in the toes. Capsaicin, the pungent ingredient of hot peppers, produces analgesia by inducing retraction of nociceptive afferents from the area of innervation and is effective in treating certain neuropathic pain disorders. A randomized double-b ...
... are limited and surgery may lead to permanent numbness in the toes. Capsaicin, the pungent ingredient of hot peppers, produces analgesia by inducing retraction of nociceptive afferents from the area of innervation and is effective in treating certain neuropathic pain disorders. A randomized double-b ...
The safety of nebulization with 3 to 5 ml of adrenaline (1:1000) in
... inflammatory obstruction of the airways. Among the 184 children treated with these doses no adverse effects were observed and no patients had to abandon the studies because of side effects. Tachycardia is a common side effect of adrenaline administered subcutaneously or intravenously.12,15,22 All se ...
... inflammatory obstruction of the airways. Among the 184 children treated with these doses no adverse effects were observed and no patients had to abandon the studies because of side effects. Tachycardia is a common side effect of adrenaline administered subcutaneously or intravenously.12,15,22 All se ...
How Well Does Methadone Maintenance
... A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, ...
... A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, ...
Testimony of Dr. Thomas Perls
... the intent to distribute, HGH for any use in humans other than the treatment of a disease or other recognized medical condition, where such use has been authorized by the Secretary of Health and Human Services (HHS) under section 505 of the FDCA (21 USC 355) and pursuant to the order of a physician ...
... the intent to distribute, HGH for any use in humans other than the treatment of a disease or other recognized medical condition, where such use has been authorized by the Secretary of Health and Human Services (HHS) under section 505 of the FDCA (21 USC 355) and pursuant to the order of a physician ...
psychoactive substances
... Court system under the aegis of the District Court. The idea is that these Courts would be treatment focused and that problem drug users charged with non-violent offences could be diverted to treatment programmes rather than being sent to jail. Regulations made under the Misuse of Drugs Acts divide ...
... Court system under the aegis of the District Court. The idea is that these Courts would be treatment focused and that problem drug users charged with non-violent offences could be diverted to treatment programmes rather than being sent to jail. Regulations made under the Misuse of Drugs Acts divide ...
GYNO-DAKTARIN™ Janssen Pharma
... nents in the membrane, resulting in fungal cell necrosis. The majority of ADRs reported in clinical trials were In general, miconazole exerts a very rapid effect on pruritus, a symptom that frequently accompanies mild to moderate in severity. dermatophyte and yeast infections Postmarketing Data Adve ...
... nents in the membrane, resulting in fungal cell necrosis. The majority of ADRs reported in clinical trials were In general, miconazole exerts a very rapid effect on pruritus, a symptom that frequently accompanies mild to moderate in severity. dermatophyte and yeast infections Postmarketing Data Adve ...
Lipid Solubility Modulates pH Potentiation of Local Anesthetic Block
... the time constant of reactivation. Thus b decays linearly over time in a semilogarithmic plot. After logarithmic transformation of b, linear regression techniques were used to obtain least squares estimates of b0 and the slope (regression coefficient) of the decay. rr is simply the inverse slope. It ...
... the time constant of reactivation. Thus b decays linearly over time in a semilogarithmic plot. After logarithmic transformation of b, linear regression techniques were used to obtain least squares estimates of b0 and the slope (regression coefficient) of the decay. rr is simply the inverse slope. It ...
VP Anesthesiology Patel 2002 - University of British Columbia
... were then randomized, using a computer-based procedure, to receive an infusion of either vasopressin or norepinephrine in a double-blind fashion for 4 h. During the initial 60 min of this 4-h infusion protocol, the study drug was titrated (infusion increased by 7 ml/h every 5–10 min), and the prestu ...
... were then randomized, using a computer-based procedure, to receive an infusion of either vasopressin or norepinephrine in a double-blind fashion for 4 h. During the initial 60 min of this 4-h infusion protocol, the study drug was titrated (infusion increased by 7 ml/h every 5–10 min), and the prestu ...
AMERICAN ACADEMY OF PEDIATRICS Adolescents and Anabolic
... 12-week cycles. The injectable forms are favored by users because they are less hepatotoxic than oral preparations. However, the oral preparations tend to be cleared more rapidly from the system and may be preferred when drug testing is anticipated. The simultaneous use of multiple steroid preparati ...
... 12-week cycles. The injectable forms are favored by users because they are less hepatotoxic than oral preparations. However, the oral preparations tend to be cleared more rapidly from the system and may be preferred when drug testing is anticipated. The simultaneous use of multiple steroid preparati ...
Paracetamol - A Review of Three Routes of Administration - e
... is conjugated with arachidonic acid to form Narachidonoylphenolamine (AM404).2 AM404 is a known activator of the capsaicin receptor (TRPV1) and the cannabinoid CB1 receptor system both of which confer analgesia in the central nervous system. This pathway may also account for the antipyretic effect o ...
... is conjugated with arachidonic acid to form Narachidonoylphenolamine (AM404).2 AM404 is a known activator of the capsaicin receptor (TRPV1) and the cannabinoid CB1 receptor system both of which confer analgesia in the central nervous system. This pathway may also account for the antipyretic effect o ...
Characteristics and Consequences of Use of Anabolic Androgenic
... Substances with anabolic properties were not discovered until the 19th century, when John Hunter, a Scottish physician developed methods to transplant testicular tissue into foreign tissue. His work inspired another physician, Berthold of Göttingen, to experiment with castrated roosters. In 1849, Be ...
... Substances with anabolic properties were not discovered until the 19th century, when John Hunter, a Scottish physician developed methods to transplant testicular tissue into foreign tissue. His work inspired another physician, Berthold of Göttingen, to experiment with castrated roosters. In 1849, Be ...
Effects of single nucleotide polymorphisms and
... xenobiotics. Several sequence variations have been discovered in the SLCO1B1 gene encoding OATP1B1. The aim of this study was to investigate the effects of SLCO1B1 polymorphisms on the pharmacokinetics of atorvastatin in healthy volunteers of Macedonian origin. Twenty three participants, genotyped f ...
... xenobiotics. Several sequence variations have been discovered in the SLCO1B1 gene encoding OATP1B1. The aim of this study was to investigate the effects of SLCO1B1 polymorphisms on the pharmacokinetics of atorvastatin in healthy volunteers of Macedonian origin. Twenty three participants, genotyped f ...
Analgesic Effects of Topical Ketamine
... resulted in 3 hours of benefit and reported no side effects. This enabled him to taper off of the systemic opiates that were being used for analgesia. Two double‐blinded RCT’s show conflicting results in pain reduction using the addition of ketamine 1.5% to 2% cream in CINP. d) Miscellaneous cau ...
... resulted in 3 hours of benefit and reported no side effects. This enabled him to taper off of the systemic opiates that were being used for analgesia. Two double‐blinded RCT’s show conflicting results in pain reduction using the addition of ketamine 1.5% to 2% cream in CINP. d) Miscellaneous cau ...
Venous Relaxation Caused by Acetylcholine Acting on the
... acetylcholine (5xlO~ u to 5 X 10"7 g/ml) was investigated. The lower doses (5 X Kh11 to lf>8 g/ml) had no effect on base-line tension (0.845 ± 0.480 g). A dose of 5 X 10-« g/ml caused a slight contraction in seven of the nine strips (mean increase in tension, 0.030±0.010 g); 10-7 g/ml caused all of ...
... acetylcholine (5xlO~ u to 5 X 10"7 g/ml) was investigated. The lower doses (5 X Kh11 to lf>8 g/ml) had no effect on base-line tension (0.845 ± 0.480 g). A dose of 5 X 10-« g/ml caused a slight contraction in seven of the nine strips (mean increase in tension, 0.030±0.010 g); 10-7 g/ml caused all of ...
Overcoming the Stratum Corneum: The Modulation of Skin Penetration
... 1980s. They can be used as penetration enhancers for hydrophilic and lipophilic substances and for peptide molecules as well, e.g. insulin and vasopressin. Interestingly, Azone and derivatives are effective penetration enhancers when used in low concentrations (1–5%). Their activity can be increased ...
... 1980s. They can be used as penetration enhancers for hydrophilic and lipophilic substances and for peptide molecules as well, e.g. insulin and vasopressin. Interestingly, Azone and derivatives are effective penetration enhancers when used in low concentrations (1–5%). Their activity can be increased ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.