Liposomal drug delivery systems: From concept to clinical applications
... Another problem was the rapid clearance of the ‘classical’ liposomes from circulation by uptake into the cells of the mononuclear phagocyte system (MPS), predominantly in the liver and spleen [20,63,64]. Except for the treatment of diseases where there was an MPS involvement [31], the rapid uptake o ...
... Another problem was the rapid clearance of the ‘classical’ liposomes from circulation by uptake into the cells of the mononuclear phagocyte system (MPS), predominantly in the liver and spleen [20,63,64]. Except for the treatment of diseases where there was an MPS involvement [31], the rapid uptake o ...
Pharmacokinetics and pharmacodynamics of the - e
... clinical practice in the 1950s (tetracycline) while others have recently been approved (the glycylcycline, tigecycline) or are in pre-clinical development (the aminomethylcycline, PTK 0796). Given the duration over which these drugs have been developed and clinically used it will be no surprise that ...
... clinical practice in the 1950s (tetracycline) while others have recently been approved (the glycylcycline, tigecycline) or are in pre-clinical development (the aminomethylcycline, PTK 0796). Given the duration over which these drugs have been developed and clinically used it will be no surprise that ...
product monograph
... An FDA meta-analysis of randomized placebo controlled trials, in which antiepileptic drugs were used for various indications, has shown a small increased risk of suicidal ideation and behaviour in patients treated with these drugs. The mechanism of this risk is not known. There were 43,892 patients ...
... An FDA meta-analysis of randomized placebo controlled trials, in which antiepileptic drugs were used for various indications, has shown a small increased risk of suicidal ideation and behaviour in patients treated with these drugs. The mechanism of this risk is not known. There were 43,892 patients ...
product monograph
... Drugs with alpha-adrenergic blocking effects have been reported to induce priapism. Priapism has been reported with risperidone during post-marketing surveillance. This adverse reaction, as with other psychotropic drugs, did not appear to be dose dependent and did not correlate with the duration of ...
... Drugs with alpha-adrenergic blocking effects have been reported to induce priapism. Priapism has been reported with risperidone during post-marketing surveillance. This adverse reaction, as with other psychotropic drugs, did not appear to be dose dependent and did not correlate with the duration of ...
Development of nanovectors for the targeted drug delivery of antimalarials Patricia Urbán
... the mosquito bite for non-inmune individuals, and consist in a wide range of flulike symptoms including headache, nausea and cycles of fever. These symptoms are nonspecific and similar to the symptoms of a minor systemic viral illness. Complications of P. falciparum malaria may lead to severe malari ...
... the mosquito bite for non-inmune individuals, and consist in a wide range of flulike symptoms including headache, nausea and cycles of fever. These symptoms are nonspecific and similar to the symptoms of a minor systemic viral illness. Complications of P. falciparum malaria may lead to severe malari ...
epilepsy - Government Madurai Medical College
... long-lasting pathologic change in the CNS that transforms a presumably normal neural network into This process is known as epileptogenesis, ...
... long-lasting pathologic change in the CNS that transforms a presumably normal neural network into This process is known as epileptogenesis, ...
34 ECDD 2006/4.3 ...
... Furthermore new developments show strong interactions between the opioid and the NMDA system in the brain of animals. In contrast to earlier findings new results point to NMDA receptors and not sigma-receptors as having a role in the morphine withdrawal response (Brent et al, 1993). Gonzalez et al ( ...
... Furthermore new developments show strong interactions between the opioid and the NMDA system in the brain of animals. In contrast to earlier findings new results point to NMDA receptors and not sigma-receptors as having a role in the morphine withdrawal response (Brent et al, 1993). Gonzalez et al ( ...
Research Review
... psychological trauma and where the person’s response involved intense fear, helplessness, or horror. Symptoms of PTSD are divided into three categories: 1) re-experiencing of the event, 2) avoidance of stimuli, and 3) persistent symptoms of increased arousal. The critical underlying psychobiological ...
... psychological trauma and where the person’s response involved intense fear, helplessness, or horror. Symptoms of PTSD are divided into three categories: 1) re-experiencing of the event, 2) avoidance of stimuli, and 3) persistent symptoms of increased arousal. The critical underlying psychobiological ...
Mucoadhesive Drug Delivery Systems
... Advantages • It allows local modification of tissue permeability, inhibition of protease activity or reduction in immunogenic response, thus selective use of therapeutic agents like peptides proteins and ionized species can be achieved. • Drugs which are unstable in acidic environment of stomach or ...
... Advantages • It allows local modification of tissue permeability, inhibition of protease activity or reduction in immunogenic response, thus selective use of therapeutic agents like peptides proteins and ionized species can be achieved. • Drugs which are unstable in acidic environment of stomach or ...
10.4103_0975-1483.63169
... enzyme.[10] Many adverse drug–drug interactions of clinical interest can be attributed to the pharmacokinetic and pharmacodynamic changes that occur due to the alterations in hepatic drug metabolic pathways catalyzed by the CYP system. Statins are mainly considered for long-term use and often consti ...
... enzyme.[10] Many adverse drug–drug interactions of clinical interest can be attributed to the pharmacokinetic and pharmacodynamic changes that occur due to the alterations in hepatic drug metabolic pathways catalyzed by the CYP system. Statins are mainly considered for long-term use and often consti ...
Drug-induced oral lichenoid reactions. A literature review
... The term “histologically compatible with” is to be used in application to all histopathological findings less clearly compliant with the mentioned criteria. Final diagnosis of oral lichen planus and oral lichenoid lesions: The clinical and histopathological criteria must be included in order to esta ...
... The term “histologically compatible with” is to be used in application to all histopathological findings less clearly compliant with the mentioned criteria. Final diagnosis of oral lichen planus and oral lichenoid lesions: The clinical and histopathological criteria must be included in order to esta ...
Queensland Health Presentation Template - Dark Blue
... Improving co-ordination between GPs, pharmacists, specialists, and pain & addiction management services Preventing drug overdose and other drug use related injuries (better education & access to support networks), e.g. fentanyl alert, overdose and vein care resources Partnership and informatio ...
... Improving co-ordination between GPs, pharmacists, specialists, and pain & addiction management services Preventing drug overdose and other drug use related injuries (better education & access to support networks), e.g. fentanyl alert, overdose and vein care resources Partnership and informatio ...
concerta - Janssen
... CONCERTA® should be used cautiously in patients with mild hypertension and other cardiovascular conditions. Blood pressure should be monitored at appropriate intervals in patients receiving CONCERTA®, especially in patients with hypertension. In the laboratory classroom clinical trials in children ( ...
... CONCERTA® should be used cautiously in patients with mild hypertension and other cardiovascular conditions. Blood pressure should be monitored at appropriate intervals in patients receiving CONCERTA®, especially in patients with hypertension. In the laboratory classroom clinical trials in children ( ...
JRRD Efficacy of gabapentin in treating chronic phantom limb and residual
... treatment for chronic PLP and RLP. Gabapentin is derived by addition of a cyclohexyl group to the backbone of gamma-aminobutyric acid (GABA). In brain membranes, gabapentin interacts with a high-affinity binding site, which is an auxiliary subunit of voltage-sensitive calcium channels. Human and rat ...
... treatment for chronic PLP and RLP. Gabapentin is derived by addition of a cyclohexyl group to the backbone of gamma-aminobutyric acid (GABA). In brain membranes, gabapentin interacts with a high-affinity binding site, which is an auxiliary subunit of voltage-sensitive calcium channels. Human and rat ...
Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs
... Granulation lowers the effective surface area of the bitter substance that come in contact with the tongue upon oral intake. Liquid and low melting point waxes such as glycerol palmitostearate, glyceryl behenate and hydrogenated castor oil are commonly used ingredients during the granulation to achi ...
... Granulation lowers the effective surface area of the bitter substance that come in contact with the tongue upon oral intake. Liquid and low melting point waxes such as glycerol palmitostearate, glyceryl behenate and hydrogenated castor oil are commonly used ingredients during the granulation to achi ...
1 Chiari Malformation: A Literature Review Jessica Heithoff
... and spine. Therefore, pressure builds up in the brain causing an abnormally large head or mental defects. A flexible tube called a shunt may need to be placed from the head to under the skin in the chest or abdomen to divert and drain the excess fluid to be absorbed by the body.6,7 Chiari Malformati ...
... and spine. Therefore, pressure builds up in the brain causing an abnormally large head or mental defects. A flexible tube called a shunt may need to be placed from the head to under the skin in the chest or abdomen to divert and drain the excess fluid to be absorbed by the body.6,7 Chiari Malformati ...
PDF - Stanford University
... in G-allele homozygotes relative to carriers of the A allele. Interestingly, several lines of research have implicated altered brainstem morphometry in the pathophysiology of autism. Specifically, smaller brainstem volumes have been reported in young autistic children (e.g., Hashimoto et al., 1993). ...
... in G-allele homozygotes relative to carriers of the A allele. Interestingly, several lines of research have implicated altered brainstem morphometry in the pathophysiology of autism. Specifically, smaller brainstem volumes have been reported in young autistic children (e.g., Hashimoto et al., 1993). ...
1 Chiari Malformation: A Literature Review Jessica Heithoff
... and spine. Therefore, pressure builds up in the brain causing an abnormally large head or mental defects. A flexible tube called a shunt may need to be placed from the head to under the skin in the chest or abdomen to divert and drain the excess fluid to be absorbed by the body.6,7 Chiari Malformati ...
... and spine. Therefore, pressure builds up in the brain causing an abnormally large head or mental defects. A flexible tube called a shunt may need to be placed from the head to under the skin in the chest or abdomen to divert and drain the excess fluid to be absorbed by the body.6,7 Chiari Malformati ...
The Relationship between Drug-Induced Neurogenesis and Pain Behavior in Mice.
... cells, therefore the large fiber input ultimately results in an inhibitory effect upon the transmission cells. By considering both input from peripheral sensory neurons and the role of interneurons, the Gate Control Theory accounts for the potential of pain modulation at the level of the spinal cord ...
... cells, therefore the large fiber input ultimately results in an inhibitory effect upon the transmission cells. By considering both input from peripheral sensory neurons and the role of interneurons, the Gate Control Theory accounts for the potential of pain modulation at the level of the spinal cord ...
Patient Registries and Participating in Clinical Trials
... Escalating doses to learn side effects, safety, best dose ...
... Escalating doses to learn side effects, safety, best dose ...
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE
... The toxicity of vitamins B1, B6 and B12 is very low. The data available to date do not suggest any potential risk for humans. The literature available on the subject does not contain any findings indicating that vitamins B1, B6 and B12 have carcinogenic, mutagenic or teratogenic properties. Chronic ...
... The toxicity of vitamins B1, B6 and B12 is very low. The data available to date do not suggest any potential risk for humans. The literature available on the subject does not contain any findings indicating that vitamins B1, B6 and B12 have carcinogenic, mutagenic or teratogenic properties. Chronic ...
Pain Management: Acute and Chronic Pain
... A client’s self-report of pain is the single most reliable indicator of the existence and intensity of pain and any related discomfort. Pain is individualistic. A misconception about pain is that chronic pain is psychological. The belief that administering analgesics regularly will lead to drug ad ...
... A client’s self-report of pain is the single most reliable indicator of the existence and intensity of pain and any related discomfort. Pain is individualistic. A misconception about pain is that chronic pain is psychological. The belief that administering analgesics regularly will lead to drug ad ...
Understanding the Mechanisms of Action of Methotrexate
... accumulation of AICAR. Because AICAR inhibits AMP deaminase (AMPDA), an increased AICAR level leads to the release of intracellular adenine nucleotides and adenosine, either or both, into the extracellular space. Extracellular AMP, ADP, and ATP can be dephosphorylated to adenosine by the serial acti ...
... accumulation of AICAR. Because AICAR inhibits AMP deaminase (AMPDA), an increased AICAR level leads to the release of intracellular adenine nucleotides and adenosine, either or both, into the extracellular space. Extracellular AMP, ADP, and ATP can be dephosphorylated to adenosine by the serial acti ...
Pediatric Codeine Formularly Restriction
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.