Botulinum Toxin in the Treatment of Chronic Pain and Headaches
... — Abnormal calcium channels that influence presynaptic neurotransmitter release — Abnormal glutamate metabolism — Deficiency of systemic and brain magnesium ...
... — Abnormal calcium channels that influence presynaptic neurotransmitter release — Abnormal glutamate metabolism — Deficiency of systemic and brain magnesium ...
Gabapentin or Pregabalin for neuropathic pain?
... There have been no studies looking at a switch from pregabalin to gabapentin, however, there have been a few studies looking at a switch from gabapentin to pregabalin which have used various strategies and dosing regimens to undertake the switch – some strategies including direct switch and dose-tap ...
... There have been no studies looking at a switch from pregabalin to gabapentin, however, there have been a few studies looking at a switch from gabapentin to pregabalin which have used various strategies and dosing regimens to undertake the switch – some strategies including direct switch and dose-tap ...
Insulin-like actions of vanadium: Potential as a
... Vanadium compounds are glucose-lowering agents that are shown to mimic/enhance most of the metabolic actions of insulin both in vitro and in vivo. Several studies have demonstrated that vanadium treatment lowers plasma glucose levels in experimental models of type 1 diabetes and enhances insulin sen ...
... Vanadium compounds are glucose-lowering agents that are shown to mimic/enhance most of the metabolic actions of insulin both in vitro and in vivo. Several studies have demonstrated that vanadium treatment lowers plasma glucose levels in experimental models of type 1 diabetes and enhances insulin sen ...
Answer key 2012
... a) They have an affinity for the agonist binding site on receptor b) They have no intrinsic activity c) They cause parallels rightward shift of the control dose response curve d) Maximum response of agonist cannot be achieved in their presence by increasing the concentration of the agonist Q.17 Atyp ...
... a) They have an affinity for the agonist binding site on receptor b) They have no intrinsic activity c) They cause parallels rightward shift of the control dose response curve d) Maximum response of agonist cannot be achieved in their presence by increasing the concentration of the agonist Q.17 Atyp ...
RP-HPLC Analysis of Aspirin - Indian Journal of Pharmaceutical
... Antifungal activities of different extracts of Millingtonia hortensis were investigated against various fungal pathogens. Methanol extract was found to have stronger activity than fluconazole against yeast like fungi: 4 fold against Candida krusei with 4 µg/ml minimal inhibitory concentration and 2 ...
... Antifungal activities of different extracts of Millingtonia hortensis were investigated against various fungal pathogens. Methanol extract was found to have stronger activity than fluconazole against yeast like fungi: 4 fold against Candida krusei with 4 µg/ml minimal inhibitory concentration and 2 ...
Mephedrone
... pharmacological targets of mephedrone in rats to establish the basis of the mechanism of action of this drug. They performed several in vitro experiments studying the effect of mephedrone on monoamine uptake and the displacement of several specific radioligands. In isolated synaptosomes from rat cor ...
... pharmacological targets of mephedrone in rats to establish the basis of the mechanism of action of this drug. They performed several in vitro experiments studying the effect of mephedrone on monoamine uptake and the displacement of several specific radioligands. In isolated synaptosomes from rat cor ...
Adolescence as a Unique Period of Vulnerability to Environmental
... an especially vulnerable period not only for the potential of nicotine exposure to produce dependence, but also for nicotine’s impact on anxiety. Nicotine, the major psychoactive ingredient in tobacco, has been demonstrated to increase stress and anxiety in human users, despite tobacco users claimin ...
... an especially vulnerable period not only for the potential of nicotine exposure to produce dependence, but also for nicotine’s impact on anxiety. Nicotine, the major psychoactive ingredient in tobacco, has been demonstrated to increase stress and anxiety in human users, despite tobacco users claimin ...
(By authority conferred on the board of pharmacy by sections... and 7217 of 1978 PA 368, MCL 333.7201, 333.7204, 333.7211,... DEPARTMENT OF LICENSING AND REGULATORY AFFAIRS
... by the federal food and drug administration as a drug, and contains any quantity of the following substances, their salts, isomers (whether optical, positional, or geometric), homologues (analogs), and salts of isomers and homologues (analogs), unless specifically excepted, whenever the existence of ...
... by the federal food and drug administration as a drug, and contains any quantity of the following substances, their salts, isomers (whether optical, positional, or geometric), homologues (analogs), and salts of isomers and homologues (analogs), unless specifically excepted, whenever the existence of ...
THERAPEUTIC MDMA (ECSTASY): THE FEDERAL GOVERNMENT
... to validate their claims regarding the therapeutic value of MDMA. The problem is not inherent in the regulations themselves but in the fact that the FDA can act arbitrarily regarding the approval of research with Schedule I drugs. FDA risk/benefit calculations used to evaluate the safety of studies ...
... to validate their claims regarding the therapeutic value of MDMA. The problem is not inherent in the regulations themselves but in the fact that the FDA can act arbitrarily regarding the approval of research with Schedule I drugs. FDA risk/benefit calculations used to evaluate the safety of studies ...
CYCLODEXTRINS
... surface and a lipophilic central cavity. Cyclodextrin molecules are relatively large with a number of hydrogen donors and acceptors and, thus, in general they do not permeate lipophilic membranes. In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqu ...
... surface and a lipophilic central cavity. Cyclodextrin molecules are relatively large with a number of hydrogen donors and acceptors and, thus, in general they do not permeate lipophilic membranes. In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqu ...
PDF 838 kb - Patented Medicine Prices Review Board
... are not excessive; and to report on pharmaceutical trends of all medicines and on R&D spending by patentees. The PMPRB reports annually to Parliament, through the Minister of Health, on its activities, on pharmaceutical trends relating to all medicines, and on the R&D spending by patentees. ...
... are not excessive; and to report on pharmaceutical trends of all medicines and on R&D spending by patentees. The PMPRB reports annually to Parliament, through the Minister of Health, on its activities, on pharmaceutical trends relating to all medicines, and on the R&D spending by patentees. ...
GPAT-2012 PAPER
... Q.51 For the equation PV = nRT to hold true for a gas, all of the following conditions are necessary EXCEPT for ONE. Identify that. (A) The molecules of gas must be of negligible volume (B) Collisions between molecules must be perfectly elastic (C) The velocities of all molecules must be equal (D) ...
... Q.51 For the equation PV = nRT to hold true for a gas, all of the following conditions are necessary EXCEPT for ONE. Identify that. (A) The molecules of gas must be of negligible volume (B) Collisions between molecules must be perfectly elastic (C) The velocities of all molecules must be equal (D) ...
Stomach-brain communication by vagal afferents in response
... Rudolf Schicho, Irmgard T. Lippe, and Peter Holzer. Stomachbrain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Am J Physiol Gastrointest Liver Physiol 286: G403–G411, 2004. First published October 30, 2003; 10.1152/ajpgi.00308.2003.— ...
... Rudolf Schicho, Irmgard T. Lippe, and Peter Holzer. Stomachbrain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Am J Physiol Gastrointest Liver Physiol 286: G403–G411, 2004. First published October 30, 2003; 10.1152/ajpgi.00308.2003.— ...
GPAT-2012 PAPER
... Q.51 For the equation PV = nRT to hold true for a gas, all of the following conditions are necessary EXCEPT for ONE. Identify that. (A) The molecules of gas must be of negligible volume (B) Collisions between molecules must be perfectly elastic (C) The velocities of all molecules must be equal (D) ...
... Q.51 For the equation PV = nRT to hold true for a gas, all of the following conditions are necessary EXCEPT for ONE. Identify that. (A) The molecules of gas must be of negligible volume (B) Collisions between molecules must be perfectly elastic (C) The velocities of all molecules must be equal (D) ...
(Dosing, switching, and other practical information).
... 4. Correll CU. From receptor pharmacology to improved outcomes: individualising the selection, dosing, and switching of antipsychotics, 2010, European Psychiatry, 25, S12-S21. ...
... 4. Correll CU. From receptor pharmacology to improved outcomes: individualising the selection, dosing, and switching of antipsychotics, 2010, European Psychiatry, 25, S12-S21. ...
The Management of Persistent Pain in Older Persons
... have had mixed results.16 In the final analysis, age-related changes in pain perception are probably not clinically significant. The most common strategy to manage pain is to use analgesic drugs. Unfortunately, older patients have been systematically excluded from clinical trials of such drugs. In o ...
... have had mixed results.16 In the final analysis, age-related changes in pain perception are probably not clinically significant. The most common strategy to manage pain is to use analgesic drugs. Unfortunately, older patients have been systematically excluded from clinical trials of such drugs. In o ...
Central Nervous System Permeation of Non
... acting in both the peripheral tissues and the central nervous system (CNS). However, knowledge on CNS permeation of these drugs in children in sparse. Therefore cerebrospinal fluid (CSF) penetration of diclofenac, ibuprofen, indomethacin, ketorolac, and paracetamol was studied in 160 healthy childre ...
... acting in both the peripheral tissues and the central nervous system (CNS). However, knowledge on CNS permeation of these drugs in children in sparse. Therefore cerebrospinal fluid (CSF) penetration of diclofenac, ibuprofen, indomethacin, ketorolac, and paracetamol was studied in 160 healthy childre ...
an-update-of-taste-m.. - Scholars Research Library
... Recently, a fifth basic taste umami has been discovered. The umami is the taste of certain amino acids[6,7]. There is often correlation between the chemical structure of compound and its taste. Low molecular weight salts tend to taste salty where as high molecular weight salts tend toward bitterness ...
... Recently, a fifth basic taste umami has been discovered. The umami is the taste of certain amino acids[6,7]. There is often correlation between the chemical structure of compound and its taste. Low molecular weight salts tend to taste salty where as high molecular weight salts tend toward bitterness ...
Epidural Analgesia and Anesthesia
... proximity to their site of action either at receptors in the spinal cord or at nerves as they leave the spinal cord. Binding to specific receptors is maximized, producing more profound analgesia and allowing a lower total drug dose to be used compared with systemic administration. This dose reductio ...
... proximity to their site of action either at receptors in the spinal cord or at nerves as they leave the spinal cord. Binding to specific receptors is maximized, producing more profound analgesia and allowing a lower total drug dose to be used compared with systemic administration. This dose reductio ...
- ISpatula
... • After insulin has entered the circulation, it diffuses into tissues, where it is bound by specialized receptors that are found on the membranes of most tissues. • The biologic responses promoted by these insulin-receptor complexes have been identified in the primary target tissues, ie, liver, musc ...
... • After insulin has entered the circulation, it diffuses into tissues, where it is bound by specialized receptors that are found on the membranes of most tissues. • The biologic responses promoted by these insulin-receptor complexes have been identified in the primary target tissues, ie, liver, musc ...
1 Anish et al Journal of Drug Delivery & Therapeutics; 2012, 2(1)
... of both the body and the mind. However dedicated research from scientists all over the world has made it possible to treat, prevent and eradicate many of these diseases that plague man. The field of pharmaceutical science has been developing steadily over the years, and has today become invaluable i ...
... of both the body and the mind. However dedicated research from scientists all over the world has made it possible to treat, prevent and eradicate many of these diseases that plague man. The field of pharmaceutical science has been developing steadily over the years, and has today become invaluable i ...
![Chemical Information Review Document for [CAS No. 15920-93-1]](http://s1.studyres.com/store/data/008885558_1-892577a7b84a797338d53de0798d9615-300x300.png)
Chemical Information Review Document for [CAS No. 15920-93-1]
... brain cells, L-BMAA (5 mM [0.6 mg/mL]) increased intracellular calcium levels in a dose-dependent manner in the presence of bicarbonate ion. In rat cerebellar granule cells and ventral spinal cord cells, cell death was induced. Dose-dependent toxicity was also seen in rat neuronal cells and hippoca ...
... brain cells, L-BMAA (5 mM [0.6 mg/mL]) increased intracellular calcium levels in a dose-dependent manner in the presence of bicarbonate ion. In rat cerebellar granule cells and ventral spinal cord cells, cell death was induced. Dose-dependent toxicity was also seen in rat neuronal cells and hippoca ...
Pain White Paper by Joseph Vaughan, M.D.
... 2005; Olesen, 2009; Edelmayer, 2009; Galletti, 2009; Burstein, 2010; d’Andrea, 2010; Burstein, 2011; Noseda, 2011; Burstein, 2012). Many of the treatments for both pain and headache are directed at the periphery (Richards, 2013), most especially for pain and topically applied medications, though cen ...
... 2005; Olesen, 2009; Edelmayer, 2009; Galletti, 2009; Burstein, 2010; d’Andrea, 2010; Burstein, 2011; Noseda, 2011; Burstein, 2012). Many of the treatments for both pain and headache are directed at the periphery (Richards, 2013), most especially for pain and topically applied medications, though cen ...
M P D U
... injection (i.e., delivered via the eye). Genentech also manufactures Avastin, which FDA approved in 2004 to treat various forms of cancer. Ophthalmologists also use Avastin in an off-label manner to treat wet AMD. When using Avastin to treat wet AMD, physicians typically inject a much smaller amount ...
... injection (i.e., delivered via the eye). Genentech also manufactures Avastin, which FDA approved in 2004 to treat various forms of cancer. Ophthalmologists also use Avastin in an off-label manner to treat wet AMD. When using Avastin to treat wet AMD, physicians typically inject a much smaller amount ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.