Medical Emergencies and Adverse Events in Ecstasy Users
... have confirmed that pure MDMA can damage liver cells and one of these studies found that hyperthermia increases vulnerability to this damage. Although the MDMA concentrations used in these studies are high, they could be attained in individuals taking high doses or having impaired MDMA metabolism (d ...
... have confirmed that pure MDMA can damage liver cells and one of these studies found that hyperthermia increases vulnerability to this damage. Although the MDMA concentrations used in these studies are high, they could be attained in individuals taking high doses or having impaired MDMA metabolism (d ...
Direct and quantitative evaluation of the human CYP3A4
... heterologous oligomers, etc.) (Parmentier et al., 2007). Other in vitro techniques, like human liver microsomes (HLM), require the use of inhibitors, which suffer from a lack of specificity (e.g. antibody anti-CYP450) or have too specific in vitro conditions of use (e.g. chemical competitive CYP450 ...
... heterologous oligomers, etc.) (Parmentier et al., 2007). Other in vitro techniques, like human liver microsomes (HLM), require the use of inhibitors, which suffer from a lack of specificity (e.g. antibody anti-CYP450) or have too specific in vitro conditions of use (e.g. chemical competitive CYP450 ...
S F R SAMHSA
... Few clinical trials have considered gender as a factor. However, in a trial that explored genderbased differences in response to opioid agonist therapies, Jones et al. (2005) found that the female subjects who received buprenorphine had less drug use than those who received methadone, while the male ...
... Few clinical trials have considered gender as a factor. However, in a trial that explored genderbased differences in response to opioid agonist therapies, Jones et al. (2005) found that the female subjects who received buprenorphine had less drug use than those who received methadone, while the male ...
Sulfato de Atropina. Monografia.
... Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration, which results from actions of the toxic agent on the central nervous system. Atropine-induced parasympathetic inhibition ma ...
... Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration, which results from actions of the toxic agent on the central nervous system. Atropine-induced parasympathetic inhibition ma ...
Pharmacological Treatment of Post-Anesthetic Shivering: An Educational Outreach Project.
... Upon initial examination of the accumulated evidence, it was evident an abundance of studies existed. Although the evidence search located many RCTs, the majority of those studies existed in both systematic reviews located by this author, therefore this review does not include those studies. A SR co ...
... Upon initial examination of the accumulated evidence, it was evident an abundance of studies existed. Although the evidence search located many RCTs, the majority of those studies existed in both systematic reviews located by this author, therefore this review does not include those studies. A SR co ...
Effect of Khat chewing on the bioavailability of ampicillin and
... air transport, the chewing habit has spread considerably in countries where Khat does not grow. Shipments of Khat have even been observed by custom authorities in France, Denmark, Great Britain and USA.1 The widespread chewing of Khat in Yemen is a habit that has a deep-rooted sociocultural traditio ...
... air transport, the chewing habit has spread considerably in countries where Khat does not grow. Shipments of Khat have even been observed by custom authorities in France, Denmark, Great Britain and USA.1 The widespread chewing of Khat in Yemen is a habit that has a deep-rooted sociocultural traditio ...
Quetiapine for insomnia: A review of the literature
... quetiapine (50 or 100 mg) compared with $0.05 per tablet of hydroxyzine hydrochloride (100 mg), making quetiapine 90 times more expensive than hydroxyzine, another agent used to treat insomnia.16 A retrospective chart review of 692 soldiers treated with quetiapine at Madigan Army Medical Center in T ...
... quetiapine (50 or 100 mg) compared with $0.05 per tablet of hydroxyzine hydrochloride (100 mg), making quetiapine 90 times more expensive than hydroxyzine, another agent used to treat insomnia.16 A retrospective chart review of 692 soldiers treated with quetiapine at Madigan Army Medical Center in T ...
A New Type of Signaling Pathways as Pilomotor Lines along Skin
... (10). HPLC: Spectra-Physics; Detector: FL2000; Excition: 280 nm; Emission: 316 nm; Mobile phase: 0.1 M NaH2PO4 + EDTA 50 mg; Flow rate: Gradient washing. In contrast, 3 samples of liquid from similar incision, remained for 10 min but without acupuncture, were measured. For determining the tissue cat ...
... (10). HPLC: Spectra-Physics; Detector: FL2000; Excition: 280 nm; Emission: 316 nm; Mobile phase: 0.1 M NaH2PO4 + EDTA 50 mg; Flow rate: Gradient washing. In contrast, 3 samples of liquid from similar incision, remained for 10 min but without acupuncture, were measured. For determining the tissue cat ...
- Boehringer Ingelheim (Canada)
... bromide either alone or in combination with an adrenergic beta2-agonist solution has come in contact with the eyes. Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g., eye pain or discomfort, blurred vision, visual halos or colored images in associat ...
... bromide either alone or in combination with an adrenergic beta2-agonist solution has come in contact with the eyes. Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g., eye pain or discomfort, blurred vision, visual halos or colored images in associat ...
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
... gastrointestinal symptoms (e.g. nausea, vomiting, diarrhea). As these syndromes may result in potentially life-threatening conditions, treatment should be discontinued if such events occur and supportive symptomatic treatment should be initiated. If concomitant treatment of ZOFRAN® or ZOFRAN® ODT wi ...
... gastrointestinal symptoms (e.g. nausea, vomiting, diarrhea). As these syndromes may result in potentially life-threatening conditions, treatment should be discontinued if such events occur and supportive symptomatic treatment should be initiated. If concomitant treatment of ZOFRAN® or ZOFRAN® ODT wi ...
(NP) Rats
... 0.125% (w / v) s.,ccharin, w ith EtOH added in 2% increments every third day until a concentratio n of lO'Yo (v / v) is obtained. Although the amount of the cocktail consumed declines .1S EtOH concentratio n increases, EtO,., intake levels s tabilize and remain mensurable. 61\Cs were approxima tely ...
... 0.125% (w / v) s.,ccharin, w ith EtOH added in 2% increments every third day until a concentratio n of lO'Yo (v / v) is obtained. Although the amount of the cocktail consumed declines .1S EtOH concentratio n increases, EtO,., intake levels s tabilize and remain mensurable. 61\Cs were approxima tely ...
Active Transport of Fentanyl by the Blood-Brain Barrier1
... capacity and ko/kt is the KM or the supernatant drug concentration CS, which leads to 50% occupancy (inhibition) of transporters. Cell-associated [3H]fentanyl data, after being normalized for their protein content, were all fit simultaneously to eq. 1 using a constant weight and TableCurve2D (SPSS, ...
... capacity and ko/kt is the KM or the supernatant drug concentration CS, which leads to 50% occupancy (inhibition) of transporters. Cell-associated [3H]fentanyl data, after being normalized for their protein content, were all fit simultaneously to eq. 1 using a constant weight and TableCurve2D (SPSS, ...
1. Exposure Data - IARC Monographs
... as a single daily dose. Doses as high as 120 mg/day (20 mg every 4 h) may be used in severe thyrotoxicosis (‘thyroid storm’) (Cooper, 1998). Studies have shown better compliance with methimazole than with propylthiouracil (see monograph in this volume), most likely due to the single daily dose of th ...
... as a single daily dose. Doses as high as 120 mg/day (20 mg every 4 h) may be used in severe thyrotoxicosis (‘thyroid storm’) (Cooper, 1998). Studies have shown better compliance with methimazole than with propylthiouracil (see monograph in this volume), most likely due to the single daily dose of th ...
PRODUCT MONOGRAPH Cipralex Escitalopram Oxalate
... monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase in the early stages of recovery. Therefore, high-risk patients should be closely supervised throughout therapy with consideration to the possible need for hospitalization. In order to min ...
... monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase in the early stages of recovery. Therefore, high-risk patients should be closely supervised throughout therapy with consideration to the possible need for hospitalization. In order to min ...
Zebrafish as tools for drug discovery
... to screening, zebrafish stand out for their highly conserved integrative physiology. Unlike yeast, worms or flies, zebrafish possess recognizable organ systems — livers, hearts, kidneys, pancreases and so on. Although there are some major differences resulting from adaptation to aquatic life, most z ...
... to screening, zebrafish stand out for their highly conserved integrative physiology. Unlike yeast, worms or flies, zebrafish possess recognizable organ systems — livers, hearts, kidneys, pancreases and so on. Although there are some major differences resulting from adaptation to aquatic life, most z ...
Comparison of the Effects of Pilocarpine Solution and Tablet on
... Results: Systemic (5 mg tablet) and topical (2% solution) use of pilocarpine significantly increased salivary flow rate in healthy subjects compared to placebo (p<0.001). In both the pilocarpine solution and tablet groups, salivary flow rates at 120 minutes after administration remained increased. S ...
... Results: Systemic (5 mg tablet) and topical (2% solution) use of pilocarpine significantly increased salivary flow rate in healthy subjects compared to placebo (p<0.001). In both the pilocarpine solution and tablet groups, salivary flow rates at 120 minutes after administration remained increased. S ...
The effect of anticholinergic drugs on the
... The results are given in Table 1, the volume after the anticholinergic drugs being listed in order of decreasing volumes of secretion for each patient. These results show that with increasing anticholinergic suppression of gastric secretion there is METHODS AND MATERIALS a drop in acid concentration ...
... The results are given in Table 1, the volume after the anticholinergic drugs being listed in order of decreasing volumes of secretion for each patient. These results show that with increasing anticholinergic suppression of gastric secretion there is METHODS AND MATERIALS a drop in acid concentration ...
the PDF
... Abstract. Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer’s disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing pref ...
... Abstract. Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer’s disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing pref ...
MHRA recommendations on simvastatin interactions: What are the
... The MHRA Drug Safety Update (August 2012) highlights changes to the simvastatin SmPC regarding interactions that can increase the risk of myopathy and/or rhabdomyolysis. When used with amlodipine, the maximum dose of simvastatin is now 20mg; higher doses are ‘off-label’. For patients taking amlodipi ...
... The MHRA Drug Safety Update (August 2012) highlights changes to the simvastatin SmPC regarding interactions that can increase the risk of myopathy and/or rhabdomyolysis. When used with amlodipine, the maximum dose of simvastatin is now 20mg; higher doses are ‘off-label’. For patients taking amlodipi ...
Presentations Indications Dosage and Administration
... respiratory drive and increase the airway resistance to the point of apnoea. Acute abdominal conditions. Methadone may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Plasma amylase and lipase determinations should not be performed within 24 hours after a methad ...
... respiratory drive and increase the airway resistance to the point of apnoea. Acute abdominal conditions. Methadone may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Plasma amylase and lipase determinations should not be performed within 24 hours after a methad ...
447 kB - Propofol
... • Free propofol may exert its painful effect by stimulating the kallikrein-kinin system, resulting in the generation of bradykinin, which stimulates ...
... • Free propofol may exert its painful effect by stimulating the kallikrein-kinin system, resulting in the generation of bradykinin, which stimulates ...
150-505-1-SP - Baqiyatallah University of Medical Sciences
... therapeutic managements of ischemic-reperfusion injury are complex due to the fact that the inhibition of inflammation resulting of ischemia-reperfusion injury may impair protective physiological reactions that its result may be associated with immune suppression. So while restoring blood flow to th ...
... therapeutic managements of ischemic-reperfusion injury are complex due to the fact that the inhibition of inflammation resulting of ischemia-reperfusion injury may impair protective physiological reactions that its result may be associated with immune suppression. So while restoring blood flow to th ...
Concurrent Access to Nicotine and SucroseREVISION
... class, prior experience with the drug, individual differences in sensitivity to drug reinforcement, and the schedule conditions under which the choice is offered. Nicotine is somewhat puzzling because it is highly addictive (Carter et al. 2009; Stolerman and Jarvis 1995), yet by some measures its re ...
... class, prior experience with the drug, individual differences in sensitivity to drug reinforcement, and the schedule conditions under which the choice is offered. Nicotine is somewhat puzzling because it is highly addictive (Carter et al. 2009; Stolerman and Jarvis 1995), yet by some measures its re ...
PrVIBRAMYCIN* CAPSULES
... stable calcium complex in any bone-forming tissue, though in vitro it binds calcium less strongly than other tetracyclines. It should be anticipated that the use of VIBRAMYCIN/VIBRA-TABS during tooth development (last trimester of pregnancy, during lactation, neonatal period and early childhood to t ...
... stable calcium complex in any bone-forming tissue, though in vitro it binds calcium less strongly than other tetracyclines. It should be anticipated that the use of VIBRAMYCIN/VIBRA-TABS during tooth development (last trimester of pregnancy, during lactation, neonatal period and early childhood to t ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.