Opioid analgesics in palliative care
... release capsules (Palladone) and modified release capsules (Palladone SR). Despite offering some benefits to patients unable to tolerate morphine, immediate release hydromorphone is only available in two strengths: 1.3mg and 2.6mg. This, together with an equianalgesic ratio of hydromorphone to morph ...
... release capsules (Palladone) and modified release capsules (Palladone SR). Despite offering some benefits to patients unable to tolerate morphine, immediate release hydromorphone is only available in two strengths: 1.3mg and 2.6mg. This, together with an equianalgesic ratio of hydromorphone to morph ...
VIAGRA* (sildenafil citrate) Product Monograph Page 46 of 49 PART
... VIAGRA belongs to a class of medicine called phosphodiesterase type 5 (PDE5) inhibitors. Following sexual stimulation, VIAGRA works by helping to relax the blood vessels in your penis by allowing blood to flow into your penis. This results in improved erectile function. When it should not be used: ...
... VIAGRA belongs to a class of medicine called phosphodiesterase type 5 (PDE5) inhibitors. Following sexual stimulation, VIAGRA works by helping to relax the blood vessels in your penis by allowing blood to flow into your penis. This results in improved erectile function. When it should not be used: ...
ISOA/ARF Drug Development Tutorial
... The “drugability” of a given target is defined either by how well a therapeutic, such as small molecule drugs or antibodies, can access the target, or by the efficacy a therapeutic can actually achieve. A long list a parameters influences drugability of a given target; these include cellular locatio ...
... The “drugability” of a given target is defined either by how well a therapeutic, such as small molecule drugs or antibodies, can access the target, or by the efficacy a therapeutic can actually achieve. A long list a parameters influences drugability of a given target; these include cellular locatio ...
Several hospitals are participating in a study to test the efficacy of a
... half of the participants receive the drug and half receive a placebo. Neither the physicians in charge of the study nor the patients are permitted to know what the patients have received. Which of the following steps in the drug development process does this scenario most closely describe? ...
... half of the participants receive the drug and half receive a placebo. Neither the physicians in charge of the study nor the patients are permitted to know what the patients have received. Which of the following steps in the drug development process does this scenario most closely describe? ...
See the tutorial - The GENESIS Simulator
... How we do it using GENESIS Some strategies for analyzing the results – Matlab provides a flexible platform for customization and automation of data analysis. – Movies can help you explain what’s going on in the model – Compare multiple models, each representing a distinct alternative case. – Compare ...
... How we do it using GENESIS Some strategies for analyzing the results – Matlab provides a flexible platform for customization and automation of data analysis. – Movies can help you explain what’s going on in the model – Compare multiple models, each representing a distinct alternative case. – Compare ...
PowerPoint Chapter 5
... Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. ...
... Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. ...
Does Combined Antipsychotic Treatment Provide Better Control on
... patients with schizophrenia than the monotherapy? Objective: Combined antipsychotic treatment is frequently used in clinical practice either to improve the symptom control or to reduce the severity of side effects. The expected benefits by combining different antipsychotics include active cross-titr ...
... patients with schizophrenia than the monotherapy? Objective: Combined antipsychotic treatment is frequently used in clinical practice either to improve the symptom control or to reduce the severity of side effects. The expected benefits by combining different antipsychotics include active cross-titr ...
' STATE OF WISCONSIN DEPARTMENT OF JUSTICE
... characteristics" : (a) "their benefits outweigh their risks," (b) "the potential for misuse and abuse is low," (c) the "consumer can use them for self-diagnosed conditions," (d) "they can be adequately labeled" and (e) "health practitioners are not needed for the safe and effective use of the produc ...
... characteristics" : (a) "their benefits outweigh their risks," (b) "the potential for misuse and abuse is low," (c) the "consumer can use them for self-diagnosed conditions," (d) "they can be adequately labeled" and (e) "health practitioners are not needed for the safe and effective use of the produc ...
Fluoroquinolone resistance in mycobacterium tuberculosis strains
... infections in Kenya including pneumonia. A proportion (not less than 10%) of patients with community acquired pneumonia, have TB and the use of fluoroquinolones in these patients may not only delay the diagnosis of TB but also stimulate the development of fluoroqunilones resistance in MTB. This stud ...
... infections in Kenya including pneumonia. A proportion (not less than 10%) of patients with community acquired pneumonia, have TB and the use of fluoroquinolones in these patients may not only delay the diagnosis of TB but also stimulate the development of fluoroqunilones resistance in MTB. This stud ...
Thesis - CiteSeerX
... more conditions are present at the same time, the person is said to have multimorbidity30 or complex health problems.31 Increasing rates of co-morbidity are often followed by an increase in drug use. Women tend to live longer than men but to have more health problems, the so-called male-female healt ...
... more conditions are present at the same time, the person is said to have multimorbidity30 or complex health problems.31 Increasing rates of co-morbidity are often followed by an increase in drug use. Women tend to live longer than men but to have more health problems, the so-called male-female healt ...
Verapamil vs. Diltiazem
... Relatively minor side effects are those of vasodilation--headaches and dizziness, with occasional palpitations and hypotension [2]. Ankle edema may also result (Table IV-2). The side effect causing trouble, especially in elderly patients, is constipation. Straining at stool can in turn cause cardio ...
... Relatively minor side effects are those of vasodilation--headaches and dizziness, with occasional palpitations and hypotension [2]. Ankle edema may also result (Table IV-2). The side effect causing trouble, especially in elderly patients, is constipation. Straining at stool can in turn cause cardio ...
Dyslipidemia PHCL 442
... • Flushing & headache: with immediate release, can be reduced by giving aspirin • Increase blood glucose by 10-20% • Hepatotoxicity: sustained release formulation, defined as 3 times the upper limit of liver enzymes & could be associated with symptoms as fatigue, anorexia, malaise & nausea • Niasepa ...
... • Flushing & headache: with immediate release, can be reduced by giving aspirin • Increase blood glucose by 10-20% • Hepatotoxicity: sustained release formulation, defined as 3 times the upper limit of liver enzymes & could be associated with symptoms as fatigue, anorexia, malaise & nausea • Niasepa ...
Drug Therapy
... • Flushing & headache: with immediate release, can be reduced by giving aspirin • Increase blood glucose by 10-20% • Hepatotoxicity: sustained release formulation, defined as 3 times the upper limit of liver enzymes & could be associated with symptoms as fatigue, anorexia, malaise & nausea • Niasepa ...
... • Flushing & headache: with immediate release, can be reduced by giving aspirin • Increase blood glucose by 10-20% • Hepatotoxicity: sustained release formulation, defined as 3 times the upper limit of liver enzymes & could be associated with symptoms as fatigue, anorexia, malaise & nausea • Niasepa ...
Clinical pharmacology of dobutamine and dopamine in preterm
... possesses a bulky aromatic substituent on the amino group.1 The pharmacological effects of dobutamine are due to direct interaction with b receptors. Its actions do not appear to result from release of norepinephrine from sympathetic nerve endings, nor are they exerted by dopamine receptors.2 Dobuta ...
... possesses a bulky aromatic substituent on the amino group.1 The pharmacological effects of dobutamine are due to direct interaction with b receptors. Its actions do not appear to result from release of norepinephrine from sympathetic nerve endings, nor are they exerted by dopamine receptors.2 Dobuta ...
Drug-induced psychomimetic effects as a model for psychosis
... and reserpine, let to the introduction of many more antipsychotic drugs with a similar mechanism of action, which are now referred to as typical antipsychotics (e.g. haloperidol, flupentixol, droperidol). In 1963, Carlsson and Lidqvist discovered that dopamine acts as a neurotransmitter (Carlsson a ...
... and reserpine, let to the introduction of many more antipsychotic drugs with a similar mechanism of action, which are now referred to as typical antipsychotics (e.g. haloperidol, flupentixol, droperidol). In 1963, Carlsson and Lidqvist discovered that dopamine acts as a neurotransmitter (Carlsson a ...
Central Nervous System Stimulants, Anticonvulsants
... Adverse Reactions of Anticonvulsants The most common adverse reaction is sedation. Can range from drowsiness to somnolence Agitation rather than sedation may occur in some patients. Adverse reactions may be reduced or eliminated with therapy or a decrease in dose. ...
... Adverse Reactions of Anticonvulsants The most common adverse reaction is sedation. Can range from drowsiness to somnolence Agitation rather than sedation may occur in some patients. Adverse reactions may be reduced or eliminated with therapy or a decrease in dose. ...
Metal-Based Therapeutics for Leishmaniasis
... metal compounds to treat tropical parasitic diseases, which has been mostly based on an empirical use. Various inorganic salts have been administered against the major tropical diseases, sometimes with very good results. The best-known example is a series of antimony compounds such as sodium stibogl ...
... metal compounds to treat tropical parasitic diseases, which has been mostly based on an empirical use. Various inorganic salts have been administered against the major tropical diseases, sometimes with very good results. The best-known example is a series of antimony compounds such as sodium stibogl ...
INTRODUCTION Neurotrophic factors (NTs) are secreted pro
... known to affect the central and/or peripheral nervous system, causing changes that may result in neurological and psychiatric disorders. Because of the limited accessibility of the mammalian nervous tissue, new strategies are being developed to identify biochemical parameters of neuronal cell functi ...
... known to affect the central and/or peripheral nervous system, causing changes that may result in neurological and psychiatric disorders. Because of the limited accessibility of the mammalian nervous tissue, new strategies are being developed to identify biochemical parameters of neuronal cell functi ...
View Full Text-PDF
... toxicity for overdose and long term administration. The present study is an attempt to understand the toxic effect of this antidepressant on the behaviour and fitness of Drosophila melanogaster. Does this antidepressant have toxic effect on the reproductive behaviour and fitness of the individuals? ...
... toxicity for overdose and long term administration. The present study is an attempt to understand the toxic effect of this antidepressant on the behaviour and fitness of Drosophila melanogaster. Does this antidepressant have toxic effect on the reproductive behaviour and fitness of the individuals? ...
N Gokal Counting the Costs
... Its context sensitive half life is independent of the duration of the infusion. However, remifentanil is an expensive opioid. Its use typically mandates a continuous infusion pump which takes time to set up and its use has been associated with opioid induced hyperalgesia. Because its actions short l ...
... Its context sensitive half life is independent of the duration of the infusion. However, remifentanil is an expensive opioid. Its use typically mandates a continuous infusion pump which takes time to set up and its use has been associated with opioid induced hyperalgesia. Because its actions short l ...
butyrylcholinesterase accelerates cocaine metabolism: in vitro and
... somewhat greater doses of BChE (13.7 or 27.4 mg/kg) provided protection against seizures and death in mice (Hoffman et al., 1996). Thus, increasing BChE levels may be a useful approach for treating cocaine abuse (Gorelick, 1997). The current study sought to further characterize the ability of BChE t ...
... somewhat greater doses of BChE (13.7 or 27.4 mg/kg) provided protection against seizures and death in mice (Hoffman et al., 1996). Thus, increasing BChE levels may be a useful approach for treating cocaine abuse (Gorelick, 1997). The current study sought to further characterize the ability of BChE t ...
Focus on Lisdexamfetamine: A Review of its use in Child and
... placebo at all time points. In addition, for the secondary endpoint of ADHD-RS-IV scores, LDX (all doses) were superior to placebo (p< 0.0001). Changes in PERMP-A and PERMP-C scores in the LDX groups compared to those receiving placebo were statistically significant as well. Childress et al. (2010) ...
... placebo at all time points. In addition, for the secondary endpoint of ADHD-RS-IV scores, LDX (all doses) were superior to placebo (p< 0.0001). Changes in PERMP-A and PERMP-C scores in the LDX groups compared to those receiving placebo were statistically significant as well. Childress et al. (2010) ...
Article - Archive ouverte UNIGE
... patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging from moderate to severe according to the diagnostic criteria of the International Classification of Diseases, 10th edition (ICD-10) [29]. These patients presented the fo ...
... patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging from moderate to severe according to the diagnostic criteria of the International Classification of Diseases, 10th edition (ICD-10) [29]. These patients presented the fo ...
piracetam and platelets
... bilayers and induces changes in membrane structure can explain that this drug works not only in the brain but also at the level of blood cells (19). Its activity is much more pronounced when membranes are impaired (e.g. in aging). Since changes at the level of the platelet membrane seem to be involv ...
... bilayers and induces changes in membrane structure can explain that this drug works not only in the brain but also at the level of blood cells (19). Its activity is much more pronounced when membranes are impaired (e.g. in aging). Since changes at the level of the platelet membrane seem to be involv ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.