B N ULLETI I N F O R M A T I O...
... combativeness, a condition which is also observed among those in withdrawal from addiction to GHB and its analogs. GHB analogs are known to produce side effects such as topical irritation to the skin and eyes, nausea, vomiting, incontinence, loss of consciousness, seizures, liver damage, kidney fail ...
... combativeness, a condition which is also observed among those in withdrawal from addiction to GHB and its analogs. GHB analogs are known to produce side effects such as topical irritation to the skin and eyes, nausea, vomiting, incontinence, loss of consciousness, seizures, liver damage, kidney fail ...
Recent changes in Europe`s MDMA/ecstasy market
... There are currently a small number of OCGs involved, and it is common for production facilities to specialise in one production step, such as pre-precursor conversion, MDMA oil synthesis, crystallisation or tableting. Although all these steps are routinely performed in the Netherlands and Belgium, t ...
... There are currently a small number of OCGs involved, and it is common for production facilities to specialise in one production step, such as pre-precursor conversion, MDMA oil synthesis, crystallisation or tableting. Although all these steps are routinely performed in the Netherlands and Belgium, t ...
Novel Approaches to the Treatment of Systemic Anthrax
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
ADHD Doctor Discussion Guide
... Let the doctor know how you are responding to any treatment, because everyone responds differently. ...
... Let the doctor know how you are responding to any treatment, because everyone responds differently. ...
BIOLOGICAL EVALUATION OF OPIOIDS, STIMULANTS, AND
... is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and its Ncyclopropylmethyl analog, NIH 11150, were active as antinociceptive agents, albeit with the Ncyclopropylme ...
... is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and its Ncyclopropylmethyl analog, NIH 11150, were active as antinociceptive agents, albeit with the Ncyclopropylme ...
Application of Hepatocytes for In Vitro Uptake Studies
... Protein quantification data in cell lines and hepatocytes Uptake CL of test drug in cell lines Selective substrate model to predict contribution of both OATP’s Relative expression model (REF) to predict contribution of both OATP’s Figure adapted from Hirano et al., JPET. 311: 139-146, 2004 ...
... Protein quantification data in cell lines and hepatocytes Uptake CL of test drug in cell lines Selective substrate model to predict contribution of both OATP’s Relative expression model (REF) to predict contribution of both OATP’s Figure adapted from Hirano et al., JPET. 311: 139-146, 2004 ...
Hydrocodone Bitartrate and Acetaminophen Tablets, USP
... Hydrocodone causes miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are not pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings). Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. T ...
... Hydrocodone causes miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are not pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings). Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. T ...
Salvia Divinorum
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
GABA-Enriched Functional Foods Aiding in Health and
... Gamma-Aminobutyric acid (GABA) plays a major role in human health. Since it is found throughout the body, its effects are widespread, and numerous health benefits of GABA have been found, including decreasing symptoms of anxiety, depression and schizophrenia. Despite the fact that only small amounts ...
... Gamma-Aminobutyric acid (GABA) plays a major role in human health. Since it is found throughout the body, its effects are widespread, and numerous health benefits of GABA have been found, including decreasing symptoms of anxiety, depression and schizophrenia. Despite the fact that only small amounts ...
Histones Differentially Modulate the Anticoagulant and
... activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renowned that cationic proteins can interact with UFH by electrostatic forces and neutralize its activity, as in the case of protamine sulfate, which is indeed used as heparin ant ...
... activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renowned that cationic proteins can interact with UFH by electrostatic forces and neutralize its activity, as in the case of protamine sulfate, which is indeed used as heparin ant ...
magnesium sulfate in water for injection
... the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium is said to have a depressant effect on the central nervous system, but it does not adversely affect the mother, fetus or neonate when used as directed in eclampsia or pre-eclampsia. Normal serum magnesium le ...
... the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium is said to have a depressant effect on the central nervous system, but it does not adversely affect the mother, fetus or neonate when used as directed in eclampsia or pre-eclampsia. Normal serum magnesium le ...
5 1 Prereview - World Health Organization
... As a central nervous system stimulant, lisdexamfetamine is used as an adjunct in the treatment of attention deficit hyperactivity disorder (ADHD). As a prodrug, lisdexamfetamine was specifically designed as an abuse-resistant product. After oral administration and absorption, enzyme hydrolysis follo ...
... As a central nervous system stimulant, lisdexamfetamine is used as an adjunct in the treatment of attention deficit hyperactivity disorder (ADHD). As a prodrug, lisdexamfetamine was specifically designed as an abuse-resistant product. After oral administration and absorption, enzyme hydrolysis follo ...
New Zealand Practice Guidelines for Opioid Substitution Treatment
... are free to: share ie, copy and redistribute the material in any medium or format; adapt ie, remix, transform and build upon the material. You must give appropriate credit, provide a link to the licence and indicate if changes were made. ...
... are free to: share ie, copy and redistribute the material in any medium or format; adapt ie, remix, transform and build upon the material. You must give appropriate credit, provide a link to the licence and indicate if changes were made. ...
New Zealand Practice Guidelines for Opioid
... are free to: share ie, copy and redistribute the material in any medium or format; adapt ie, remix, transform and build upon the material. You must give appropriate credit, provide a link to the licence and indicate if changes were made. ...
... are free to: share ie, copy and redistribute the material in any medium or format; adapt ie, remix, transform and build upon the material. You must give appropriate credit, provide a link to the licence and indicate if changes were made. ...
Investigator`s Brochure - Multidisciplinary Association for
... from a safety perspective, recent studies have examined the effects of this compound on attention, prosocial effects, memory and brain activity, and human drug discrimination. Findings from an initial report indicated that MDMA-assisted psychotherapy could be conducted safely in people with chronic ...
... from a safety perspective, recent studies have examined the effects of this compound on attention, prosocial effects, memory and brain activity, and human drug discrimination. Findings from an initial report indicated that MDMA-assisted psychotherapy could be conducted safely in people with chronic ...
Clinical pharmacology and abuse potential of gamma‐hydroxybutyric acid (GHB)
... participated in 5 experimental sessions in the framework of a clinical trial. Drug conditions were a single oral dose of GHB (40 or 60 mg/kg), ethanol (0.7 g/kg), flunitrazepam (1.25 mg),and placebo. All active conditions induced positive effects related to their abuse potential. The administrat ...
... participated in 5 experimental sessions in the framework of a clinical trial. Drug conditions were a single oral dose of GHB (40 or 60 mg/kg), ethanol (0.7 g/kg), flunitrazepam (1.25 mg),and placebo. All active conditions induced positive effects related to their abuse potential. The administrat ...
Contrasting Actions of Lanthanum on Different Recombinant
... Lanthanum is a trivalent cation and is the most electropositive element of the rare earth group. Its mechanisms of action at the cellular and molecular level have not been studied extensively until recently. Functional studies have indicated that lanthanum, unlike most divalent cations, increases GA ...
... Lanthanum is a trivalent cation and is the most electropositive element of the rare earth group. Its mechanisms of action at the cellular and molecular level have not been studied extensively until recently. Functional studies have indicated that lanthanum, unlike most divalent cations, increases GA ...
Prokinetic agents: current aspects with focus on cisapride
... who take metoclopramide, but are usually temporary, mild and reversible after termination of administration. They include: stress, somnolence, fatigue, increased mammary glands, galactorrhea and menstrual disorders. Extrapyramidal symptoms are developed in about 1-2% of patients but only after long ...
... who take metoclopramide, but are usually temporary, mild and reversible after termination of administration. They include: stress, somnolence, fatigue, increased mammary glands, galactorrhea and menstrual disorders. Extrapyramidal symptoms are developed in about 1-2% of patients but only after long ...
Product Monograph ZANTAC Histamine H
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
Effects of Diazinon and Diazoxon on Astrocyte
... et al., 2003). Astrocytes form and maintain the blood-brain barrier, control levels of the neurotransmitters glutamate and dopamine in the synapses, as well as mediate neuronal differentiation, neurite outgrowth, synapse formation, and synaptic transmission (Benarroch, 2005; He and Sun, 2007). The m ...
... et al., 2003). Astrocytes form and maintain the blood-brain barrier, control levels of the neurotransmitters glutamate and dopamine in the synapses, as well as mediate neuronal differentiation, neurite outgrowth, synapse formation, and synaptic transmission (Benarroch, 2005; He and Sun, 2007). The m ...
Product Monograph ZANTAC
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
Inducible Nitric Oxide Synthase in Long
... to hypoxia/reoxygenation increases in lipid peroxidation and proinflammatory gene responses (tumor necrosis factor ␣ and cyclooxygenase 2). Inhibition of iNOS after long-term hypoxia/reoxygenation in wild-type mice was effective in reversing the proinflammatory gene response. Conclusions: These data ...
... to hypoxia/reoxygenation increases in lipid peroxidation and proinflammatory gene responses (tumor necrosis factor ␣ and cyclooxygenase 2). Inhibition of iNOS after long-term hypoxia/reoxygenation in wild-type mice was effective in reversing the proinflammatory gene response. Conclusions: These data ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.