Clinical Pharmacokinetics and Pharmacodynamics
... KD is a 12 y.o. child admitted with status asthmaticus who is treated by her primary physician with theophylline (serum concentration is 18 mcg/ml). Based on her CXR and clinical findings, you treat her with erythromycin for ...
... KD is a 12 y.o. child admitted with status asthmaticus who is treated by her primary physician with theophylline (serum concentration is 18 mcg/ml). Based on her CXR and clinical findings, you treat her with erythromycin for ...
DrugLecture2001
... the drug is the primary factor in addiction. • The anticipated pleasure of drug-taking is the basis of addiction, not so much the pleasurable effects of the drug per se. ...
... the drug is the primary factor in addiction. • The anticipated pleasure of drug-taking is the basis of addiction, not so much the pleasurable effects of the drug per se. ...
Neuro-Science Outline
... system) are made “on demand” from lipid precursors (fat cells) already present in the neuron. Then they are released from that cell and travel backward to the presynaptic neuron, where they attach to cannabinoid receptors. Cell Communication why is this important? Since cannabinoids act on presynapt ...
... system) are made “on demand” from lipid precursors (fat cells) already present in the neuron. Then they are released from that cell and travel backward to the presynaptic neuron, where they attach to cannabinoid receptors. Cell Communication why is this important? Since cannabinoids act on presynapt ...
Respiratory System
... Not useful in managing an acute asthma attack, because they are not direct bronchodilators. These agents can block the initiation of immediate and delayed asthmatic reactions. ...
... Not useful in managing an acute asthma attack, because they are not direct bronchodilators. These agents can block the initiation of immediate and delayed asthmatic reactions. ...
GABAergic analgesia: new insights from mutant mice and subtype
... inhibitory neurotransmitter in the brain where it regulates many physiological functions including sleep, anxiety, reward and memory formation. GABAergic neurons and ionotropic GABAA receptors are also found in the spinal cord dorsal horn where they control the propagation of pain signals from the p ...
... inhibitory neurotransmitter in the brain where it regulates many physiological functions including sleep, anxiety, reward and memory formation. GABAergic neurons and ionotropic GABAA receptors are also found in the spinal cord dorsal horn where they control the propagation of pain signals from the p ...
Full version (PDF file)
... proteomic analysis of protein alterations induced by longterm stimulation of HEK293 cells stably expressing TRH-receptor and G11α protein by TRH, indicated the change of 42 proteins, but none of these proteins represented the plasma membrane protein functionally related to G-protein-mediated signali ...
... proteomic analysis of protein alterations induced by longterm stimulation of HEK293 cells stably expressing TRH-receptor and G11α protein by TRH, indicated the change of 42 proteins, but none of these proteins represented the plasma membrane protein functionally related to G-protein-mediated signali ...
07 Adrenoceptor-antagonist
... Choice of a β-adrenoceptor antagonist drug • For some diseases (e.g., myocardial infarction, migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that ...
... Choice of a β-adrenoceptor antagonist drug • For some diseases (e.g., myocardial infarction, migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that ...
Intoxicants
... – More recently, oxycodone, a deriviative of codeine was thought to be less addictive than morphine. – After World War 2, methadone became available to treat heroin addiction and withdrawal symptoms. Methadone gives less of a high, and it blocks the action of morphine and heroin. It is also fairly l ...
... – More recently, oxycodone, a deriviative of codeine was thought to be less addictive than morphine. – After World War 2, methadone became available to treat heroin addiction and withdrawal symptoms. Methadone gives less of a high, and it blocks the action of morphine and heroin. It is also fairly l ...
Effect of Ergot Alkaloids on 3H-Flunitrazepam Binding to Mouse
... compounds on GABAA receptors were also hypotesized2. Ergot drugs have been used clinically in many settings: as diagnostics, cognition enhancers and in the management of orthostatic hypotension. The primary uses of ergot alkaloids today are limited to treatment of postpartum hemorrhage and migraine. ...
... compounds on GABAA receptors were also hypotesized2. Ergot drugs have been used clinically in many settings: as diagnostics, cognition enhancers and in the management of orthostatic hypotension. The primary uses of ergot alkaloids today are limited to treatment of postpartum hemorrhage and migraine. ...
6 2006 CT Memorandum
... Cytisine is a compound derived from the plant, cytisus laburnum . It is a nicotinic partial agonist binding with high affinity to a number of different subtypes of the neuronal nicotinic receptors, including receptors composed of oca and (i2 subunits (13, 14) which are believed to be central to the ...
... Cytisine is a compound derived from the plant, cytisus laburnum . It is a nicotinic partial agonist binding with high affinity to a number of different subtypes of the neuronal nicotinic receptors, including receptors composed of oca and (i2 subunits (13, 14) which are believed to be central to the ...
Document
... • Does it actually work? • Evolution of a drug (SOSA) – Look at possible side activity of drugs • Donepezil: acetylcholinesterase inhibitor used for Alzheimer disease • Potential activity for dopamine D4 receptor • Confirmed experimentally at 600nM: design ligands with Donepezil as a hit to improve ...
... • Does it actually work? • Evolution of a drug (SOSA) – Look at possible side activity of drugs • Donepezil: acetylcholinesterase inhibitor used for Alzheimer disease • Potential activity for dopamine D4 receptor • Confirmed experimentally at 600nM: design ligands with Donepezil as a hit to improve ...
Influence of Gender and Sex Hormones on Nicotine Acute
... Tail-Flick Test. Antinociception was assessed by the tail-flick method of D’Amour and Smith (1941) as modified by Dewey et al. (1970). A control response (2– 4 s) was determined for each mouse before treatment, and a test latency was determined after drug administration. To minimize tissue damage, a ...
... Tail-Flick Test. Antinociception was assessed by the tail-flick method of D’Amour and Smith (1941) as modified by Dewey et al. (1970). A control response (2– 4 s) was determined for each mouse before treatment, and a test latency was determined after drug administration. To minimize tissue damage, a ...
Adrenergic and anti-adrenergic drugs
... ´ Effects include: increased BP, increased heart rate, relaxation of bronchial smooth muscle, vasoconstriction in peripheral blood vessels ...
... ´ Effects include: increased BP, increased heart rate, relaxation of bronchial smooth muscle, vasoconstriction in peripheral blood vessels ...
April 2017
... Suboxone® is a Schedule III Controlled Substance containing the long-acting partial opioid agonist buprenorphine in combination with the opioid antagonist naloxone. Suboxone® is FDA-approved for maintenance treatment of opioid dependence as part of a complete treatment plan that incorporates counsel ...
... Suboxone® is a Schedule III Controlled Substance containing the long-acting partial opioid agonist buprenorphine in combination with the opioid antagonist naloxone. Suboxone® is FDA-approved for maintenance treatment of opioid dependence as part of a complete treatment plan that incorporates counsel ...
The behavioral pharmacology of hallucinogens
... assessing mechanisms of action of these drugs that informs their subjective effects in man would be especially useful. The main methodology presently employed in this regard is drug discrimination. In a typical discrimination task, an animal is trained to emit one response during experimental sessio ...
... assessing mechanisms of action of these drugs that informs their subjective effects in man would be especially useful. The main methodology presently employed in this regard is drug discrimination. In a typical discrimination task, an animal is trained to emit one response during experimental sessio ...
Opioid Receptors: Oligomerization and Desensitization
... modulation of LC neuronal firing rates contributes to the physical aspects of opiate addiction, namely physical dependence and withdrawal in several species. • Chronic administration of opiate leads to upregulation of the cAMP system, which increases the intrinsic excitability of LC neurons, and the ...
... modulation of LC neuronal firing rates contributes to the physical aspects of opiate addiction, namely physical dependence and withdrawal in several species. • Chronic administration of opiate leads to upregulation of the cAMP system, which increases the intrinsic excitability of LC neurons, and the ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.