Drug/Application
... Drugs used to treat infectious agents Dosing: Antibiotics with low PAE – optimize the duration of time the serum is > MIC; Those with high PAE – peak conc. is important Used in three ways: Empirical therapy 1. Determine if infected 2. Identify site of infection 3. Ascertain possible pathogens 4. ...
... Drugs used to treat infectious agents Dosing: Antibiotics with low PAE – optimize the duration of time the serum is > MIC; Those with high PAE – peak conc. is important Used in three ways: Empirical therapy 1. Determine if infected 2. Identify site of infection 3. Ascertain possible pathogens 4. ...
What is the prognosis for new centrally-acting anti
... Westernised diet that is rich in fat and sugar and a more sedentary lifestyle. The costs of this epidemic are substantial increases in Type 2 diabetes, cardiovascular disease and some types of cancer that are certain to place a huge burden on individuals, healthcare providers and society. In this re ...
... Westernised diet that is rich in fat and sugar and a more sedentary lifestyle. The costs of this epidemic are substantial increases in Type 2 diabetes, cardiovascular disease and some types of cancer that are certain to place a huge burden on individuals, healthcare providers and society. In this re ...
Novartis Award for Hypertension Research Reconsidering the Roles
... (11HSD2), which converts cortisol and corticosterone to their MR-inactive 11-keto congeners cortisone and 11-dehydrocorticosterone. On this basis, it was proposed that conversion to receptor-inactive metabolites allows aldosterone, which is ⬎99% cyclized in solution to the 11,18 hemiacetal and the ...
... (11HSD2), which converts cortisol and corticosterone to their MR-inactive 11-keto congeners cortisone and 11-dehydrocorticosterone. On this basis, it was proposed that conversion to receptor-inactive metabolites allows aldosterone, which is ⬎99% cyclized in solution to the 11,18 hemiacetal and the ...
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES OF BENZOTHIAZOLE Research Article
... having a thiazole fused with benzene ring [1]. It is a proved fact that heterocyclic compounds containing nitrogen and sulphur possess potential pharmacological activities. Benzothiazole is usually prepared by ring closure of o-aminothiophenols with acid chlorides. Due to the immense importance in p ...
... having a thiazole fused with benzene ring [1]. It is a proved fact that heterocyclic compounds containing nitrogen and sulphur possess potential pharmacological activities. Benzothiazole is usually prepared by ring closure of o-aminothiophenols with acid chlorides. Due to the immense importance in p ...
Inhaled nicotine replacement therapy
... in either smoking cessation or a reduction in cigarette consumption [19,20]. Even the “efficacy” of e-cigarettes has been questioned because of the widely variable dosimetry across the over 250 brands on the market [16,17]; e-cigarettes generally produce relatively modest peak levels of nicotine com ...
... in either smoking cessation or a reduction in cigarette consumption [19,20]. Even the “efficacy” of e-cigarettes has been questioned because of the widely variable dosimetry across the over 250 brands on the market [16,17]; e-cigarettes generally produce relatively modest peak levels of nicotine com ...
Chapter 7: Anticholinergic (Parasympatholytic) Bronchodilators Test
... Anticholinergic (antimuscarinic) agents such as ipratropium do not have a labeled indication for asthma in the United States. Current asthma guidelines state that ipratropium may have some additive benefit when given with inhaled agonists. Antimuscarinic bronchodilators are not clearly superior to ...
... Anticholinergic (antimuscarinic) agents such as ipratropium do not have a labeled indication for asthma in the United States. Current asthma guidelines state that ipratropium may have some additive benefit when given with inhaled agonists. Antimuscarinic bronchodilators are not clearly superior to ...
Selection of Optimal Tobacco Cessation Medication Treatment in
... Approved by the FDA in May 2006, varenicline is a potent and competitive partial agonist at the alpha4/beta2 neuronal nicotinic acetylcholine receptors. It provides some nicotinelike effects to ease nicotine withdrawal symptoms. In addition, by binding strongly to those nicotinic receptors, it block ...
... Approved by the FDA in May 2006, varenicline is a potent and competitive partial agonist at the alpha4/beta2 neuronal nicotinic acetylcholine receptors. It provides some nicotinelike effects to ease nicotine withdrawal symptoms. In addition, by binding strongly to those nicotinic receptors, it block ...
Adverse Reactions to Fluoroquinolones. An Overview on
... linking felbamate has also been postulated. ...
... linking felbamate has also been postulated. ...
Histamine receptor antagonists
... receptor. H1 antagonists have several actions some of these actions are of therapeutic value and some are undesirable. 1. Sedation—A common effect of first-generation H1 antagonists is sedation, but the intensity of this effect varies among chemical subgroups. The effect is sufficiently prominent wi ...
... receptor. H1 antagonists have several actions some of these actions are of therapeutic value and some are undesirable. 1. Sedation—A common effect of first-generation H1 antagonists is sedation, but the intensity of this effect varies among chemical subgroups. The effect is sufficiently prominent wi ...
Biron_JSBMB_2015_rev - Corpus UL
... GRIP1 interaction, the 4-amino-4′-esters bearing larger substituents 4a-d were significantly less active against ER signaling and the only ones to exhibit inhibitory activity for AR signaling. In some cases cellular toxicity was observed at higher doses. The reported results confirmed the ability ...
... GRIP1 interaction, the 4-amino-4′-esters bearing larger substituents 4a-d were significantly less active against ER signaling and the only ones to exhibit inhibitory activity for AR signaling. In some cases cellular toxicity was observed at higher doses. The reported results confirmed the ability ...
Molecular Modeling: A Powerful Tool for Drug Design and Molecular
... been used in a variety of bimolecular applications. The technique, when combined with data derived from NMR studies, has been used to derive 3D structures for peptides and small proteins in cases where X-ray crystallography was not practical. Additionally, structural, dynamic and thermodynamic data ...
... been used in a variety of bimolecular applications. The technique, when combined with data derived from NMR studies, has been used to derive 3D structures for peptides and small proteins in cases where X-ray crystallography was not practical. Additionally, structural, dynamic and thermodynamic data ...
DM235 (sunifiram): a novel nootropic with
... Pentobarbitone-induced hypnosis. After mice had been given pentobarbitone sodium (60 mg kg–1 i.p.), the loss of the righting reflex was measured. The duration of hypnosis was taken as the time required to regain the righting reflex. Mice were pretreated with DM235 (0.1–1 mg kg–1 i.p.), or piracetam ...
... Pentobarbitone-induced hypnosis. After mice had been given pentobarbitone sodium (60 mg kg–1 i.p.), the loss of the righting reflex was measured. The duration of hypnosis was taken as the time required to regain the righting reflex. Mice were pretreated with DM235 (0.1–1 mg kg–1 i.p.), or piracetam ...
Chapter 5.pmd - New Age International
... Nicotine binds to the receptors in the brain where it influences the cerebral metabolism. Nicotine is then distributed throughout the body, mostly to skeletal muscles. As already mentioned, nicotine is a potent addictive substance as powerful as “hard drugs,” it acts as ...
... Nicotine binds to the receptors in the brain where it influences the cerebral metabolism. Nicotine is then distributed throughout the body, mostly to skeletal muscles. As already mentioned, nicotine is a potent addictive substance as powerful as “hard drugs,” it acts as ...
CLINTON E. CANAL, PH.D. CURRICULUM VITAE
... A novel serotonin-2 (5-HT2) modulator as a candidate drug to treat impulsive behavioral disorders and psychoses without weight gain as a side effect. Neuropsychopharmacology, 38, S104-105. 0893-133X/12 16. Canal, C.E., Morgan, D., Booth, R.G. (2013). Support for 5-HT2C receptor functional selectivit ...
... A novel serotonin-2 (5-HT2) modulator as a candidate drug to treat impulsive behavioral disorders and psychoses without weight gain as a side effect. Neuropsychopharmacology, 38, S104-105. 0893-133X/12 16. Canal, C.E., Morgan, D., Booth, R.G. (2013). Support for 5-HT2C receptor functional selectivit ...
... classic efferent cholinergic and adrenergic nerves, there are NANC sensory mechanisms, which are mediated by the release of neuropeptides. Neuronal responses may be measured in vitro using EFS with parameters that selectively activate nerves and not smooth muscle. EFS produced both a rapid cholinerg ...
Potassium Sparing Diuretics
... Indirect: inhibi@on of Na+ flux in luminal membrane e.g Triametrene, Amiloride ...
... Indirect: inhibi@on of Na+ flux in luminal membrane e.g Triametrene, Amiloride ...
1. An introduction to drugs, their action and discovery
... The section of the structure of a ligand that binds to a receptor is known as its Pharmacophore. E.g., the “quaternary nitrogens” that are believed to form the Pharmacophore of the neuromuscular blocking agent tubocrarine are separated in the molecule by a distance of 115.3 nm. H3CO HO O H2C H ...
... The section of the structure of a ligand that binds to a receptor is known as its Pharmacophore. E.g., the “quaternary nitrogens” that are believed to form the Pharmacophore of the neuromuscular blocking agent tubocrarine are separated in the molecule by a distance of 115.3 nm. H3CO HO O H2C H ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.