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... Abstract: Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling. Human serum albumin (HSA) and α1-acid glycoprotein (AGP) are two plasma proteins that bind a variety o ...
... Abstract: Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling. Human serum albumin (HSA) and α1-acid glycoprotein (AGP) are two plasma proteins that bind a variety o ...
5F-APINACA (5F-AKB-48) Review Report
... formation of mono- di-, and trihydroxylated metabolites having the hydroxyl groups on the adamantyl ring and the pentyl-indazole moiety. C. ...
... formation of mono- di-, and trihydroxylated metabolites having the hydroxyl groups on the adamantyl ring and the pentyl-indazole moiety. C. ...
A molecular basis of the therapeutic and psychoactive
... tetrahydrocannabinol (THC) molecule or its synthetic derivatives. Today, the molecular mechanisms of action of these compounds have led to a general understanding of the pharmacological effects of marihuana and of its therapeutic properties. These mechanisms involve the specific binding of THC to th ...
... tetrahydrocannabinol (THC) molecule or its synthetic derivatives. Today, the molecular mechanisms of action of these compounds have led to a general understanding of the pharmacological effects of marihuana and of its therapeutic properties. These mechanisms involve the specific binding of THC to th ...
Genetic identification of AChE as a positive modulator of addiction to
... evaluate addictive behavior. The NAc is densely innervated by cholinergic interneurons; the activity of these neurons is decreased by DA release (Alcantara et al., 2003) and their ablation increases the sensitivity to psychostimulants and the reinforcing effects of cocaine (Hikida et al., 2001). Fur ...
... evaluate addictive behavior. The NAc is densely innervated by cholinergic interneurons; the activity of these neurons is decreased by DA release (Alcantara et al., 2003) and their ablation increases the sensitivity to psychostimulants and the reinforcing effects of cocaine (Hikida et al., 2001). Fur ...
Cannabis (1)
... ingredient after THC) • A cannabinol a decomposition product of THC that accumulates as cannabis samples age. After ingestion, delta-9 is converted in the liver to 11-Hydroxy THC which is equally as potent and active. ...
... ingredient after THC) • A cannabinol a decomposition product of THC that accumulates as cannabis samples age. After ingestion, delta-9 is converted in the liver to 11-Hydroxy THC which is equally as potent and active. ...
Chapter 17
... Compare and contrast drug tolerance and drug addiction Evaluate different forms of narcotic agonists and narcotic agonist-antagonists in their ability to control pain List medications commonly used for the treatment of moderate to severe pain List behaviors that would make you believe a patient is a ...
... Compare and contrast drug tolerance and drug addiction Evaluate different forms of narcotic agonists and narcotic agonist-antagonists in their ability to control pain List medications commonly used for the treatment of moderate to severe pain List behaviors that would make you believe a patient is a ...
E-Cigarettes: A Global View - Reinsurance Group of America
... E-cigarettes present another challenge to the life underwriter and the insurance industry in general. They can be used to deliver other drugs and substances besides nicotine. Law enforcement agencies have already noted that THC, the psychoactive chemical compound found in marijuana, has quickly foun ...
... E-cigarettes present another challenge to the life underwriter and the insurance industry in general. They can be used to deliver other drugs and substances besides nicotine. Law enforcement agencies have already noted that THC, the psychoactive chemical compound found in marijuana, has quickly foun ...
Assessment of the Influence of Histaminergic Actions on Cocaine
... reported affinity for H1 histamine-antagonistic activity; however, its actions at other subtypes of histamine receptors have not been reported. Therefore, we examined the affinity of the drugs for H1, H2, and H3 histamine receptors. Although values varied across a wide range, the BZT analogs had aff ...
... reported affinity for H1 histamine-antagonistic activity; however, its actions at other subtypes of histamine receptors have not been reported. Therefore, we examined the affinity of the drugs for H1, H2, and H3 histamine receptors. Although values varied across a wide range, the BZT analogs had aff ...
The Health Consequences of Smoking - Rx for Change
... National Cancer Institute. (2008). The Role of the Media in Promoting and Reducing Tobacco Use. ...
... National Cancer Institute. (2008). The Role of the Media in Promoting and Reducing Tobacco Use. ...
Fatty acid amide hydrolase - The Scripps Research Institute
... as follows — because endocannabinoids are produced by neurons in an activity-dependent manner, disruption of FAAH function may augment CB1 signaling only in regions of the nervous system under persistent stimulation. In disorders such as inflammatory or chronic pain, which are typically associated w ...
... as follows — because endocannabinoids are produced by neurons in an activity-dependent manner, disruption of FAAH function may augment CB1 signaling only in regions of the nervous system under persistent stimulation. In disorders such as inflammatory or chronic pain, which are typically associated w ...
The Value of Phenotypic Screening to Drug Discovery
... compounds in a systems-‐ based approach using a target-‐agnos;c assay that monitors phenotypic change. – assumes that no mechanis;c informa;on is available. ...
... compounds in a systems-‐ based approach using a target-‐agnos;c assay that monitors phenotypic change. – assumes that no mechanis;c informa;on is available. ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.