I The 1982 John
... In addition to Blumberg’s research on lead poisoning, choline, and antipsychotic drugs, his numerous publications include work on antispasmodic and anticoagulants. Since 1960, he has published primarily on narcotic analgesics, antagonists, and antagonist analgesics. In addition to naloxone, these st ...
... In addition to Blumberg’s research on lead poisoning, choline, and antipsychotic drugs, his numerous publications include work on antispasmodic and anticoagulants. Since 1960, he has published primarily on narcotic analgesics, antagonists, and antagonist analgesics. In addition to naloxone, these st ...
Chapter 18 - The RedZone
... Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Highly impulsive rats: modelling an endophenotype to determine the
... that is responsible for maladaptive impulsivity. Thus, animals that exhibit trait impulsivity have provided a useful experimental approach to the investigation of impulsivity. To date, a number of studies have identified particular strains of rodents that demonstrate increased levels of impulsivity ...
... that is responsible for maladaptive impulsivity. Thus, animals that exhibit trait impulsivity have provided a useful experimental approach to the investigation of impulsivity. To date, a number of studies have identified particular strains of rodents that demonstrate increased levels of impulsivity ...
pharmacology basic principles
... 4) Using a transmembrane receptor protein G protein: Ligand binds serpentine receptor (extracellular amino terminal, intracellular carboxyl terminal) receptor activates (via interaction at 3rd cytoplasmic loop of receptor) G protein on cytoplasmic side of cell membrane swapping of GDP for GTP ( ...
... 4) Using a transmembrane receptor protein G protein: Ligand binds serpentine receptor (extracellular amino terminal, intracellular carboxyl terminal) receptor activates (via interaction at 3rd cytoplasmic loop of receptor) G protein on cytoplasmic side of cell membrane swapping of GDP for GTP ( ...
Central nervous system effects of caffeine and adenosine on fatigue
... breakdown and the resulting increase in blood and muscle lactate (2, 27, 28, 30). Therefore, these mechanisms are now thought not to play a primary role in the fatigue-delaying effects of caffeine (19). Another possibility that has received little scientific attention is that the ergogenic effect of ...
... breakdown and the resulting increase in blood and muscle lactate (2, 27, 28, 30). Therefore, these mechanisms are now thought not to play a primary role in the fatigue-delaying effects of caffeine (19). Another possibility that has received little scientific attention is that the ergogenic effect of ...
An Analysis of the Facilitatory Action of Catechol and Phenol at the
... and chloride, while the intracellular ionic composition showed a higher concentration of potassium and various organic anions. ...
... and chloride, while the intracellular ionic composition showed a higher concentration of potassium and various organic anions. ...
Comparing Inhaled Corticosteroids
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
(NP) Rats
... day. ResponSt.'"-Contingent EtOH intake without the use of sweetene rs has a lso been demonstrated in P rats with concentra tio ns as hig h as.3{)o/" (v / v) (Penn et a1. 1978; Wa ller e t a l. 1984; Murphy e t a1. 1989); howevcr, N P rals rt'Spond very little for alcohol concentrations exct.'t.>d i ...
... day. ResponSt.'"-Contingent EtOH intake without the use of sweetene rs has a lso been demonstrated in P rats with concentra tio ns as hig h as.3{)o/" (v / v) (Penn et a1. 1978; Wa ller e t a l. 1984; Murphy e t a1. 1989); howevcr, N P rals rt'Spond very little for alcohol concentrations exct.'t.>d i ...
Characterization of Two Pharmacophores on the Multidrug
... pristinamycin IIA; TTX, tentoxin; cLF, cyclo-leucinylphenylalanine; VRP, verapamil; PRG, progesterone; VBL, vinblastine; BSe-TTX, (benzoyl-4benzoyl)methylserine-tentoxin. ...
... pristinamycin IIA; TTX, tentoxin; cLF, cyclo-leucinylphenylalanine; VRP, verapamil; PRG, progesterone; VBL, vinblastine; BSe-TTX, (benzoyl-4benzoyl)methylserine-tentoxin. ...
8 Ultra-low-dose opioid antagonists enhance opioid analgesia while
... enhanced analgesic efficacy of an opiate would result in opioid sparing, and therefore a reduction in opioid-related side effects. The side effects of opiates include nausea, vomiting, pruritus, insomnia, constipation, sedation and impaired physical function (Ballantyne and Mao, 2003). In many cases ...
... enhanced analgesic efficacy of an opiate would result in opioid sparing, and therefore a reduction in opioid-related side effects. The side effects of opiates include nausea, vomiting, pruritus, insomnia, constipation, sedation and impaired physical function (Ballantyne and Mao, 2003). In many cases ...
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system
... users become addicts. Vulnerability to develop a drug addiction is influenced by a combination of genetic and environmental factors, which determine drug-induced effects and influence the progression of the different phases of addiction. Each step in the progression of addiction is characterized by ...
... users become addicts. Vulnerability to develop a drug addiction is influenced by a combination of genetic and environmental factors, which determine drug-induced effects and influence the progression of the different phases of addiction. Each step in the progression of addiction is characterized by ...
John R. Hughes, M.D. July, 2015
... Supervisor of psychiatry residents, medical students, psychology interns, and clinical psychology students on adult inpatient and outpatient services Supervisor of psychiatry residents, medical students, and psychology students in clinical research ...
... Supervisor of psychiatry residents, medical students, psychology interns, and clinical psychology students on adult inpatient and outpatient services Supervisor of psychiatry residents, medical students, and psychology students in clinical research ...
John R. Hughes, M.D. January, 2014 June 7, 1949
... First Recipient, Ove Ferno Award (for research on nicotine dependence; shared with Dorothy Hatsukami), Collegium Internationale Neuro-Psychopharmacoligicum, 1994 Top 25 Most-Cited Tobacco Control Researcher, Tobacco Control 14: 155-160, 2005 (1st in primary-author citations) Developer, Minnesota Nic ...
... First Recipient, Ove Ferno Award (for research on nicotine dependence; shared with Dorothy Hatsukami), Collegium Internationale Neuro-Psychopharmacoligicum, 1994 Top 25 Most-Cited Tobacco Control Researcher, Tobacco Control 14: 155-160, 2005 (1st in primary-author citations) Developer, Minnesota Nic ...
Dopamine and Benzodiazepine-Dependent Mechanisms
... While the direct reinforcing actions of alcohol have been investigated in the operant chamber (June, 2002), alcohol’s acute reinforcing actions, as with other abused drugs (Di Chiara and Imperato, 1985), have also been indirectly inferred/investigated via the use of locomotor activational effects (W ...
... While the direct reinforcing actions of alcohol have been investigated in the operant chamber (June, 2002), alcohol’s acute reinforcing actions, as with other abused drugs (Di Chiara and Imperato, 1985), have also been indirectly inferred/investigated via the use of locomotor activational effects (W ...
Addictiveness and Attractiveness of Tobacco Additives
... The criteria for dependence established in humans indicate that tobacco has a high addictive potential, but it remains difficult to assess the addictiveness of individual additives. In animal studies the addictive potency of the final tobacco product cannot be assessed. The reinforcing potency of dr ...
... The criteria for dependence established in humans indicate that tobacco has a high addictive potential, but it remains difficult to assess the addictiveness of individual additives. In animal studies the addictive potency of the final tobacco product cannot be assessed. The reinforcing potency of dr ...
... irritation or inflammation of the airways, and symptomatic antitussive drugs are frequently prescribed to control an abnormal cough reflex. Our aim was to evaluate the effects of moguisteine, a novel, peripheral, nonnarcotic antitussive agent, on airway inflammation induced in guinea-pigs with a var ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.