Intravenous Ondansetron as Antiemetic Prophylaxis for
... the difference in the incidence of PONV between those who did not receive (Group A) and those who received Ondansetron (Group B) during postoperative pre-recovery care. A substantial number of reports in the literature indicate that the incidence of PONV is related to factors such as patient age, ge ...
... the difference in the incidence of PONV between those who did not receive (Group A) and those who received Ondansetron (Group B) during postoperative pre-recovery care. A substantial number of reports in the literature indicate that the incidence of PONV is related to factors such as patient age, ge ...
Journal Club - Yale University
... Receptor Antagonist Aprepitant to Standard Antiemetic Therapy Improves Control of CINV; Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer 2003;97:3090-3098. ...
... Receptor Antagonist Aprepitant to Standard Antiemetic Therapy Improves Control of CINV; Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer 2003;97:3090-3098. ...
dose-effect relationship
... colchicine, an anti-inflammatory agent). Traditionally, drug binding was used to identify or purify receptors from tissue extracts; However, advances in molecular biology and genome sequencing have begun to reverse this order. Now receptors are being discovered by predicted structure or sequence hom ...
... colchicine, an anti-inflammatory agent). Traditionally, drug binding was used to identify or purify receptors from tissue extracts; However, advances in molecular biology and genome sequencing have begun to reverse this order. Now receptors are being discovered by predicted structure or sequence hom ...
What Is the Role of Neurotransmitter Systems in Cortical Seizures?
... All up to now studied agonists of glutamate receptors potentiate cortical epileptic afterdischarges but their action is different (Mareš et al. 2002b). Doses of the agonist had to be modified according to the age to have subconvulsant doses of similar potency in all three age groups. None of the tes ...
... All up to now studied agonists of glutamate receptors potentiate cortical epileptic afterdischarges but their action is different (Mareš et al. 2002b). Doses of the agonist had to be modified according to the age to have subconvulsant doses of similar potency in all three age groups. None of the tes ...
anticholinergic drugs
... • Partially metabolised by the liver. • Eliminated primarily in the urine. • Half life of about 4 hours. ...
... • Partially metabolised by the liver. • Eliminated primarily in the urine. • Half life of about 4 hours. ...
(Zofran) Training Module - Nor
... Zofran may have value in the treatment of schizophrenia, as an adjunct to haloperidol. Parkinson’s: Studies have indicated that Zofran may be a possible treatment for psychosis resulting from advanced Parkinson’s disease. Alcoholism: Zofran has been found to lower the cravings for alcohol, espec ...
... Zofran may have value in the treatment of schizophrenia, as an adjunct to haloperidol. Parkinson’s: Studies have indicated that Zofran may be a possible treatment for psychosis resulting from advanced Parkinson’s disease. Alcoholism: Zofran has been found to lower the cravings for alcohol, espec ...
drug treatment of gastric diseases of dogs and cats
... age. Dosage for motion sickness is 8 mg/kg PO q 24H. Dosage for acute vomiting is 1 mg/kg SC q 24 H for up to 5 days. The drug is metabolized via hepatic P450 enzymes. Safe drug and side effects are similar to placebo. It was more effective than metoclopramide in a European clinical study in reducin ...
... age. Dosage for motion sickness is 8 mg/kg PO q 24H. Dosage for acute vomiting is 1 mg/kg SC q 24 H for up to 5 days. The drug is metabolized via hepatic P450 enzymes. Safe drug and side effects are similar to placebo. It was more effective than metoclopramide in a European clinical study in reducin ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
... stomatogastric muscle of the crayfish which is apparently a chloride channel [50]. At present this is the only known action of this alkaloid, which is the most abundant pyridine in this species of Amphiporus. A variety of pyridine compounds including anabaseine and 2,3'-bipyridyl stimulate chemorece ...
... stomatogastric muscle of the crayfish which is apparently a chloride channel [50]. At present this is the only known action of this alkaloid, which is the most abundant pyridine in this species of Amphiporus. A variety of pyridine compounds including anabaseine and 2,3'-bipyridyl stimulate chemorece ...
Current Management of Alzheimer’s Disease
... * p < 0.05 vs placebo for all events except rivastigmine 1–4 mg for dizziness and sinusitis (not different from placebo). ...
... * p < 0.05 vs placebo for all events except rivastigmine 1–4 mg for dizziness and sinusitis (not different from placebo). ...
Zzzzzzz…. - The Cambridge MRCPsych Course
... • 5-HT1A partial receptor agonist • Also binds to dopamine receptors but this action less important in anxiety • 5-HT1A receptors are inhibitory autoreceptors that reduce release of 5-HT and other mediators • Also inhibit NA in locus coeruleus neurons so reduce arousal • Buspirone takes days-weeks t ...
... • 5-HT1A partial receptor agonist • Also binds to dopamine receptors but this action less important in anxiety • 5-HT1A receptors are inhibitory autoreceptors that reduce release of 5-HT and other mediators • Also inhibit NA in locus coeruleus neurons so reduce arousal • Buspirone takes days-weeks t ...
Opioids
... 80-100 times more potent than morphine few cardiovascular effects little propensity to release histamine. Because of high lipid solubility, it enters brain rapidly and produces peak analgesia in 5 min after i. v. injection. • The duration of action is short: starts wearing off after 30-40 min due to ...
... 80-100 times more potent than morphine few cardiovascular effects little propensity to release histamine. Because of high lipid solubility, it enters brain rapidly and produces peak analgesia in 5 min after i. v. injection. • The duration of action is short: starts wearing off after 30-40 min due to ...
PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING LAPAROSCOPIC BARIATRIC SURGERY
... risk of nausea and vomiting for each additional antemetic used, the present study showed no difference between granisetron alone and when droperidol was added. This was an expected result because droperidol in a dose of 1.25 mg does not have as long duration of action as granisetron12. Another reaso ...
... risk of nausea and vomiting for each additional antemetic used, the present study showed no difference between granisetron alone and when droperidol was added. This was an expected result because droperidol in a dose of 1.25 mg does not have as long duration of action as granisetron12. Another reaso ...
Drugs for peptic ulcer, emesis and reflux disorders
... decreases bioavailability of itraconazole, iron salts, ...
... decreases bioavailability of itraconazole, iron salts, ...
GASTROINTESTINAL DRUGS
... antiandrogenic action, increases plasma prolactin, inhibits degradation of estradiol by liver. High doses given for long periods have produced: ...
... antiandrogenic action, increases plasma prolactin, inhibits degradation of estradiol by liver. High doses given for long periods have produced: ...
Anti-platelets
... • Both currently available ADP-receptor antagonists are thienopyridines that can be administered orally, and absorption is approximately 80-90% • Thienopyridines are prodrugs that must be activated in the liver Uses ...
... • Both currently available ADP-receptor antagonists are thienopyridines that can be administered orally, and absorption is approximately 80-90% • Thienopyridines are prodrugs that must be activated in the liver Uses ...
Pituitary Hormones
... - MOA Unclear, its effects believed to be mediated through IGFs (Somatomedins) which are formed in the liver , kidneys, muscles and other tissues - GH stimulates growth of soft tissues and bones - ↑ lipolysis - ↑ gluconeogenesis & ↓ glucose utilization (diabetogenic effect) - PRL-like activity ...
... - MOA Unclear, its effects believed to be mediated through IGFs (Somatomedins) which are formed in the liver , kidneys, muscles and other tissues - GH stimulates growth of soft tissues and bones - ↑ lipolysis - ↑ gluconeogenesis & ↓ glucose utilization (diabetogenic effect) - PRL-like activity ...
GI Drugs
... Uses: antiemetic (reserved for vomiting resistant to other drugs) and antipsychotic Side effects: extrapyramidal effects and hyperprolactinemia o Metoclopramide MOA: D2 antagonist (anti-emesis at CTZ) and 5-HT4 agonist (increase GI motility) Uses: nausea and vomiting associated with chemothe ...
... Uses: antiemetic (reserved for vomiting resistant to other drugs) and antipsychotic Side effects: extrapyramidal effects and hyperprolactinemia o Metoclopramide MOA: D2 antagonist (anti-emesis at CTZ) and 5-HT4 agonist (increase GI motility) Uses: nausea and vomiting associated with chemothe ...
Jemds.com
... attempt to improve the use of antiemetic agents. The use of propofol in a non-sedative doses reduces the incidence of post-operative nausea and vomiting in 50% of patients.(7) The most commonly used antiemetic medications are anti-histamines, anti-cholinergic, promethazine, phenothiazine group of dr ...
... attempt to improve the use of antiemetic agents. The use of propofol in a non-sedative doses reduces the incidence of post-operative nausea and vomiting in 50% of patients.(7) The most commonly used antiemetic medications are anti-histamines, anti-cholinergic, promethazine, phenothiazine group of dr ...
The present study is to compare the efficacy of
... nausea and vomiting in patients undergoing gynaecological laparoscopy.Methodology:It is a clinical study of the comparison of efficacy of Ondansetrone, Metoclopramide and placebo in the prevention of postoperative nausea and vomiting in 60 patients in the age group 18-45 years undergoing gynecologic ...
... nausea and vomiting in patients undergoing gynaecological laparoscopy.Methodology:It is a clinical study of the comparison of efficacy of Ondansetrone, Metoclopramide and placebo in the prevention of postoperative nausea and vomiting in 60 patients in the age group 18-45 years undergoing gynecologic ...
Chapter 14 Sedative
... alpha subunits. Benzodiazepine drugs can binds to these sites,but they don’t substitute for GABA. They appear to enhance GABA’effects without directly activating GABA receptors or opening the associated chloride channels. The enhancement in chloride ion conductance induced by the interaction of benz ...
... alpha subunits. Benzodiazepine drugs can binds to these sites,but they don’t substitute for GABA. They appear to enhance GABA’effects without directly activating GABA receptors or opening the associated chloride channels. The enhancement in chloride ion conductance induced by the interaction of benz ...
Structure-Based Identification of Binding Sites, Native Ligands and
... for identifying ligands for new GPCRs is to rigorously test in vitro many hundreds of potential binding compounds. This is extremely time-consuming and as a result of the sheer scale of the task means that many important potential ligands are missed and never tested. Testing is usually limited to co ...
... for identifying ligands for new GPCRs is to rigorously test in vitro many hundreds of potential binding compounds. This is extremely time-consuming and as a result of the sheer scale of the task means that many important potential ligands are missed and never tested. Testing is usually limited to co ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... The average rate of PONV is approximately 20-30%.In certain patient population undergoing specific outpatient procedures, the incidence can still be as high as 80% [2]. After laparoscopic cholecystectomy up to 70% patients have PONV if they are not on any anti-emetic prophylaxis [3]. The process of ...
... The average rate of PONV is approximately 20-30%.In certain patient population undergoing specific outpatient procedures, the incidence can still be as high as 80% [2]. After laparoscopic cholecystectomy up to 70% patients have PONV if they are not on any anti-emetic prophylaxis [3]. The process of ...
Print
... – This is what kills you from an overdose/sedation. – Decreases respiratory center's sensitivity to higher levels of carbon dioxide in blood. ...
... – This is what kills you from an overdose/sedation. – Decreases respiratory center's sensitivity to higher levels of carbon dioxide in blood. ...
Effects of a 5‐HT3 antagonist, ondansetron, on fasting and
... small bowel water content (SBWC)12, 13 which is highly acceptable to patients. Postprandially, the SBWC depends on the balance between delivery of fluid via gastric emptying and the removal of fluid by either propulsion into the colon or absorption. In contrast, in the fasting state, fluid flow is inter ...
... small bowel water content (SBWC)12, 13 which is highly acceptable to patients. Postprandially, the SBWC depends on the balance between delivery of fluid via gastric emptying and the removal of fluid by either propulsion into the colon or absorption. In contrast, in the fasting state, fluid flow is inter ...
Neurotransmitter Receptor and Transporter Binding
... Nefazodone and venlafaxine are two of several newer antidepressants that have been introduced in the United States in the past several years. These drugs and their metabolites, like the TCAs and SSRIs, are both antagonists of monoamine transporters and receptors in the CNS. The potency of transporte ...
... Nefazodone and venlafaxine are two of several newer antidepressants that have been introduced in the United States in the past several years. These drugs and their metabolites, like the TCAs and SSRIs, are both antagonists of monoamine transporters and receptors in the CNS. The potency of transporte ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.