Left heart failure
... - Right ventricle: right atrial pressure for the right ventricle. These are the "filling pressures" Left ventricular function curve: (SV or SW against the filling pressure) Stroke volume or work ...
... - Right ventricle: right atrial pressure for the right ventricle. These are the "filling pressures" Left ventricular function curve: (SV or SW against the filling pressure) Stroke volume or work ...
Sodium–Glucose Cotransporter Inhibitors: Effects
... Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin ...
... Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin ...
Prodrugs: Effective Solutions for Solubility, Permeability and
... drug (NSAID) that can cause serious gastrointestinal bleeding, perforation and ulceration. Anthony Marfat (Pfizer Inc, USA) discussed the use of the prodrug concept in the discovery of ampiroxicam (Figure 3) as an antiinflammatory agent to reduce or eliminate the local or topical component of gastri ...
... drug (NSAID) that can cause serious gastrointestinal bleeding, perforation and ulceration. Anthony Marfat (Pfizer Inc, USA) discussed the use of the prodrug concept in the discovery of ampiroxicam (Figure 3) as an antiinflammatory agent to reduce or eliminate the local or topical component of gastri ...
Michael Barry Michael Barry - Irish Pharmaceutical Healthcare
... • a product which demonstrates non inferiority to the current standard of care ...
... • a product which demonstrates non inferiority to the current standard of care ...
In-vitro susceptibility of Giardia lamblia to albendazole
... Secnidazole, which possesses a longer half-life,25was five-fold less active than ornidazole. Similar results were obtained by Boreham et aZ.26 by use of a radiometric assay. Hemezole, a compound synthesised in Mexico, was the least active of the nitroimidazoles tested. Although nifuroxazide, etofami ...
... Secnidazole, which possesses a longer half-life,25was five-fold less active than ornidazole. Similar results were obtained by Boreham et aZ.26 by use of a radiometric assay. Hemezole, a compound synthesised in Mexico, was the least active of the nitroimidazoles tested. Although nifuroxazide, etofami ...
Antifilarial Lead Molecules Isolated from Trachyspermum ammi
... situation where everyone in that population would live into old age in full health) for river blindness and 5.5 million DALYs for lymphatic filariasis [25]. Present treatment regimens for these diseases have limitations, as the currently used antifilarial drugs are mainly microfilaricidal, with litt ...
... situation where everyone in that population would live into old age in full health) for river blindness and 5.5 million DALYs for lymphatic filariasis [25]. Present treatment regimens for these diseases have limitations, as the currently used antifilarial drugs are mainly microfilaricidal, with litt ...
Plasma amino acid levels after single-dose aspartame
... intake) level set by the Food and Drug Administration; it was selected to approximate the expected maximal amount of aspartame that an adult would consume in 10 to 15 minutes. For a 60 kg adult, 10 mg/kg aspartame is present in a little more than one quart of Kool-Aid (34.5 oz) or in three cans of a ...
... intake) level set by the Food and Drug Administration; it was selected to approximate the expected maximal amount of aspartame that an adult would consume in 10 to 15 minutes. For a 60 kg adult, 10 mg/kg aspartame is present in a little more than one quart of Kool-Aid (34.5 oz) or in three cans of a ...
Carbohydrates
... Plant constituents, as the word implies are the individual chemicals from which plants are made. These constituents are organic in nature and synthesized in plants by the activity of individual cells. The process by which these complex organic chemical constituents are formed, utilizing simple subst ...
... Plant constituents, as the word implies are the individual chemicals from which plants are made. These constituents are organic in nature and synthesized in plants by the activity of individual cells. The process by which these complex organic chemical constituents are formed, utilizing simple subst ...
A study of prescription pattern of Non steroidal anti
... COX-2) has led to a greater understanding of the mechanisms of action of NSAIDs and their toxicity3. The beneficial anti-inflammatory effect of the NSAIDs had been attributed to inhibition of COX-2, while the gastrointestinal (GI), renal and anti-platelet adverse effects were attributed to COX-1 inh ...
... COX-2) has led to a greater understanding of the mechanisms of action of NSAIDs and their toxicity3. The beneficial anti-inflammatory effect of the NSAIDs had been attributed to inhibition of COX-2, while the gastrointestinal (GI), renal and anti-platelet adverse effects were attributed to COX-1 inh ...
Tubular Secretion active transport - University of California, Berkeley
... • From 1940s-1970s, was used in pregnant women to reduce complications, but caused vaginal cancer in daughters of women who used DES during pregnancy ...
... • From 1940s-1970s, was used in pregnant women to reduce complications, but caused vaginal cancer in daughters of women who used DES during pregnancy ...
COX-2 inhibitor article for exam (medscape)
... naproxen, but not when compared with other classical NSAIDs (ibuprofen, diclofenac and nabumetone). However, many of these studies were of short duration (1-3 months), and subsequent longer-term observational studies began to reveal a different pattern of risk. A Prescription Event Monitoring study ...
... naproxen, but not when compared with other classical NSAIDs (ibuprofen, diclofenac and nabumetone). However, many of these studies were of short duration (1-3 months), and subsequent longer-term observational studies began to reveal a different pattern of risk. A Prescription Event Monitoring study ...
27 Gastrointestinal drugs
... found to be correlated with increased citrate intake.3 In a study in 5 healthy subjects given aluminium hydroxide with or without citrate solution, aluminium levels were found to be 11 micrograms/L at baseline, 44 micrograms/L when aluminium hydroxide was given, and 98 micrograms/L when citrate was ...
... found to be correlated with increased citrate intake.3 In a study in 5 healthy subjects given aluminium hydroxide with or without citrate solution, aluminium levels were found to be 11 micrograms/L at baseline, 44 micrograms/L when aluminium hydroxide was given, and 98 micrograms/L when citrate was ...
CAFERGOT
... enzyme activity can modulate the metabolic clearance of caffeine. Fluoroquinolones, mexiletine, fluvoxamine, and oral contraceptives can increase the plasma exposure of caffeine. Interactions of caffeine with sympathomimetics can lead to increased ...
... enzyme activity can modulate the metabolic clearance of caffeine. Fluoroquinolones, mexiletine, fluvoxamine, and oral contraceptives can increase the plasma exposure of caffeine. Interactions of caffeine with sympathomimetics can lead to increased ...
Development of BT1718, a novel Bicycle Drug Conjugate for the
... Table 2. The binding affinity of BT1718 to MT1-MMP from human, cyno, rat & mouse, and to related human MMPs was evaluated. BT1718 binds to MT1-MMP via the hemopexin domain, with high affinity and exquisite selectivity. In in vitro cytotoxicity assays, BT1718 kills MT1-MMP expressing EBC-1 cells with ...
... Table 2. The binding affinity of BT1718 to MT1-MMP from human, cyno, rat & mouse, and to related human MMPs was evaluated. BT1718 binds to MT1-MMP via the hemopexin domain, with high affinity and exquisite selectivity. In in vitro cytotoxicity assays, BT1718 kills MT1-MMP expressing EBC-1 cells with ...
diuretics
... 1) List 5 major types of diuretics and their mechanism and site of action 2) List the major applications and toxicities of them 3) Describe the measures that reduce K+ loss ...
... 1) List 5 major types of diuretics and their mechanism and site of action 2) List the major applications and toxicities of them 3) Describe the measures that reduce K+ loss ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.