Effect of Mulberry leaves on diabetes
... investigation. In uncontrolled diabetes, the acid phosphatase level was significantly (p<0.01) increased by 60% causing decreased functioning of ionic pumps and increased inorganic phosphate levels in blood. Mulberry leaves treatment decreased the enhanced levels of acid phosphatase (ACP) observed i ...
... investigation. In uncontrolled diabetes, the acid phosphatase level was significantly (p<0.01) increased by 60% causing decreased functioning of ionic pumps and increased inorganic phosphate levels in blood. Mulberry leaves treatment decreased the enhanced levels of acid phosphatase (ACP) observed i ...
Enhanced water solubility for enhanced oral drug delivery via the
... recognition of disulfide subunit by the enzyme glutathione, which releases the paclitaxel. High levels of this enzyme have been described in cancer cells, and one hypothesis speculates that this enzyme is involved in resistance to many anticancer drugs. The prodrug compounds were 6–100 times more sol ...
... recognition of disulfide subunit by the enzyme glutathione, which releases the paclitaxel. High levels of this enzyme have been described in cancer cells, and one hypothesis speculates that this enzyme is involved in resistance to many anticancer drugs. The prodrug compounds were 6–100 times more sol ...
SW_QA226_1_Noacs_Complementary_Medicines_Final
... interactions. The clinical implications of any interaction depend on a variety of factors, such as coadministered drugs, the health status of the patient, the composition of the herbal medicine and the dosage regimens used. Herbal medicines are not subject to the same scrutiny and regulatory process ...
... interactions. The clinical implications of any interaction depend on a variety of factors, such as coadministered drugs, the health status of the patient, the composition of the herbal medicine and the dosage regimens used. Herbal medicines are not subject to the same scrutiny and regulatory process ...
Role of cytochrome P450 in drug interactions | SpringerLink
... This pedigree is indicated by, respectively, an Arabic numeral (family), a capital letter (subfamily) and another Arabic numeral (gene), e.g. CYP1A2. The enzymes transforming drugs in humans belong to the CYP families 1–4 and more than 30 human CYP isozymes have been identified to date. It has been ...
... This pedigree is indicated by, respectively, an Arabic numeral (family), a capital letter (subfamily) and another Arabic numeral (gene), e.g. CYP1A2. The enzymes transforming drugs in humans belong to the CYP families 1–4 and more than 30 human CYP isozymes have been identified to date. It has been ...
PHL 424 5th S
... Clindamycin is nearly completely absorbed following oral administration. The presence of food in the stomach does not reduce absorption significantly It penetrates well into most tissues, with brain and CSF (even when the meninges are inflamed!) being important exceptions. It penetrates well int ...
... Clindamycin is nearly completely absorbed following oral administration. The presence of food in the stomach does not reduce absorption significantly It penetrates well into most tissues, with brain and CSF (even when the meninges are inflamed!) being important exceptions. It penetrates well int ...
Principles of early drug discovery
... bolus injection, the phosphorothioate antisense P2X3 oligonucleonucleotides had marked anti-hyperalgesic activity in the Complete Freund’s Adjuvant model, demonstrating an unambiguous role for this receptor in chronic inflammatory states. Interestingly, after administration of the antisense oligonuc ...
... bolus injection, the phosphorothioate antisense P2X3 oligonucleonucleotides had marked anti-hyperalgesic activity in the Complete Freund’s Adjuvant model, demonstrating an unambiguous role for this receptor in chronic inflammatory states. Interestingly, after administration of the antisense oligonuc ...
The Seventh Report of the Joint National Committee on Prevention
... “The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure” provides a new guideline for hypertension prevention and management. The following are the key messages: (1) In persons older than 50 years, systolic blood pressure (BP) of ...
... “The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure” provides a new guideline for hypertension prevention and management. The following are the key messages: (1) In persons older than 50 years, systolic blood pressure (BP) of ...
Antimicrob. Agents Chemother.
... 60% confluence were incubated with the test compounds for 1 h and were then infected in 96-well plates at a multiplicity of infection of ⬃0.4 with luciferaseexpressing P. berghei sporozoites obtained from freshly dissected mosquito salivary glands. The medium was replaced 24 h after infection by new ...
... 60% confluence were incubated with the test compounds for 1 h and were then infected in 96-well plates at a multiplicity of infection of ⬃0.4 with luciferaseexpressing P. berghei sporozoites obtained from freshly dissected mosquito salivary glands. The medium was replaced 24 h after infection by new ...
Tricyclic antidepressant pharmacology and therapeutic drug
... most TCAs. It is essential to be fully informed about these pharmacokinetic interactions between TCAs and SSRIs to avoid the many possible problematic and even dangerous combinations, and to make compensatory dosage adjustments. It is notable that fluvoxamine has been documented to raise concentrati ...
... most TCAs. It is essential to be fully informed about these pharmacokinetic interactions between TCAs and SSRIs to avoid the many possible problematic and even dangerous combinations, and to make compensatory dosage adjustments. It is notable that fluvoxamine has been documented to raise concentrati ...
Cardiovascular Drugs - Cardiovascular Nursing Education Associates
... – Action: direct renin inhibitor, blocks conversion of angiotensinogen to angiotensin I – Indicated for treatment of hypertension – Dose: 150 mg qd, can increase to 300 mg qd – Side effects: angioedema, hypotension, ↑ K+ – Contraindicated in severe renal failure and pregnancy – Maximum antihypertens ...
... – Action: direct renin inhibitor, blocks conversion of angiotensinogen to angiotensin I – Indicated for treatment of hypertension – Dose: 150 mg qd, can increase to 300 mg qd – Side effects: angioedema, hypotension, ↑ K+ – Contraindicated in severe renal failure and pregnancy – Maximum antihypertens ...
Molecular Pharmacology of Nucleoside and Nucleotide HIV
... Zidovudine was first synthesized in 1964 as a potential anticancer drug, but was not further developed for human use because of toxicity concerns. However, as described in the Introduction, it was found to have potent anti-HIV activity and, in 1987, was the first antiviral drug to be approved for cl ...
... Zidovudine was first synthesized in 1964 as a potential anticancer drug, but was not further developed for human use because of toxicity concerns. However, as described in the Introduction, it was found to have potent anti-HIV activity and, in 1987, was the first antiviral drug to be approved for cl ...
Chapter-7 Summary
... conditions except the case of MCC pH102. Stress testing studies by HPLC ruled out any degradation and it was concluded that most of the excipients were chemically compatible with the drug except a few. The compacted buffer granules compressed into tablets did not disintegrate within 10 minutes and f ...
... conditions except the case of MCC pH102. Stress testing studies by HPLC ruled out any degradation and it was concluded that most of the excipients were chemically compatible with the drug except a few. The compacted buffer granules compressed into tablets did not disintegrate within 10 minutes and f ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.