pharmaceutical products and drug action
... 1. THE EFFECTS OF DRUGS AND MEDICINES A PHARMACEUTICAL DRUG or MEDICINE is any chemical (natural or human-made) that does one or more or the ...
... 1. THE EFFECTS OF DRUGS AND MEDICINES A PHARMACEUTICAL DRUG or MEDICINE is any chemical (natural or human-made) that does one or more or the ...
drug metabolism
... reactions are catalyzed by enzymes isolated in the microsomal fraction of liver homogenates (the fraction derived from the endoplasmic reticulum) and by cytoplasmic enzymes. ...
... reactions are catalyzed by enzymes isolated in the microsomal fraction of liver homogenates (the fraction derived from the endoplasmic reticulum) and by cytoplasmic enzymes. ...
Disinfectant
... 1. Give an antimicrobial drug only when it is indicated by rational choices 2. Give a sufficiently large amount of an effective drug as early as possible 3. Continue treatment long enough to ensure eradication of infection ...
... 1. Give an antimicrobial drug only when it is indicated by rational choices 2. Give a sufficiently large amount of an effective drug as early as possible 3. Continue treatment long enough to ensure eradication of infection ...
PowerPoint 簡報
... give a sufficiently large amount of an effective drug as early as possible and continue treatment long enough to ensure eradication of infection, but give an antimicrobial drug only when it is indicated by rational choice. ...
... give a sufficiently large amount of an effective drug as early as possible and continue treatment long enough to ensure eradication of infection, but give an antimicrobial drug only when it is indicated by rational choice. ...
Non-competitive inhibition
... by mutases); and 6) ligases (joining of two substrates at the expense of energy, also referred to as synthetases). All discovered enzymes are identified by the prefix EC followed by an Arabic numeral based on the major class of reaction catalyzed, as indicated earlier. Furthermore, this is followed by ...
... by mutases); and 6) ligases (joining of two substrates at the expense of energy, also referred to as synthetases). All discovered enzymes are identified by the prefix EC followed by an Arabic numeral based on the major class of reaction catalyzed, as indicated earlier. Furthermore, this is followed by ...
Medicinal Lecture
... biological substrate to design an inhibiter, for example the neuraminidase inhibitor "tamiflu" is designed from sialic acid. To be able to change the chemistry without changing interaction we should understand different properties of different functional groups. That’s why isosteric and bioisosteric ...
... biological substrate to design an inhibiter, for example the neuraminidase inhibitor "tamiflu" is designed from sialic acid. To be able to change the chemistry without changing interaction we should understand different properties of different functional groups. That’s why isosteric and bioisosteric ...
Amino Alkaloids *phenylalkylamine= aromatic ring +alkyl chain +( N
... Most important derivative of this this group : Ephedrine Ephedrine A β-amino-phenylpropane derivative; 2-(methylamino)-1-phenylpropan-1-ol , which has adrenaline-like activities ( sympatho-mimetic ), but ephedrine is orally-active ,and with longer duration of action than adrenaline. It's obtained fr ...
... Most important derivative of this this group : Ephedrine Ephedrine A β-amino-phenylpropane derivative; 2-(methylamino)-1-phenylpropan-1-ol , which has adrenaline-like activities ( sympatho-mimetic ), but ephedrine is orally-active ,and with longer duration of action than adrenaline. It's obtained fr ...
Antifungal Agents
... Flucytosine (5-FC)is a water-soluble pyrimidine analog. Its spectrum of action is much narrower than that of amphotericin B. Poorly protein-bound and penetrates well into all body fluid aompartments, including the cerebrospinal fluid. ...
... Flucytosine (5-FC)is a water-soluble pyrimidine analog. Its spectrum of action is much narrower than that of amphotericin B. Poorly protein-bound and penetrates well into all body fluid aompartments, including the cerebrospinal fluid. ...
Neodecanoic Acid Product Safety Summary
... Neodecanoic Acid is used primarily as an intermediate to make other chemical products. For example, metal salts of Neodecanoic Acid can be used in a variety of applications such as paint driers, PVC stabilizers, or polymerization initiators. Ester derivatives of Neodecanoic Acid are used in surface ...
... Neodecanoic Acid is used primarily as an intermediate to make other chemical products. For example, metal salts of Neodecanoic Acid can be used in a variety of applications such as paint driers, PVC stabilizers, or polymerization initiators. Ester derivatives of Neodecanoic Acid are used in surface ...
500157 PDF File - Capellon Pharmaceuticals
... Pediatric Use: This product is not recommended for use in children under two years of age. Infants and young children are especially susceptible to the toxic effects of anticholinergics. Close supervision is recommended for infants and children with spastic paralysis or brain damage since an increas ...
... Pediatric Use: This product is not recommended for use in children under two years of age. Infants and young children are especially susceptible to the toxic effects of anticholinergics. Close supervision is recommended for infants and children with spastic paralysis or brain damage since an increas ...
Compound 48/80 (C2313) - Product Information Sheet - Sigma
... Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde; it is a mixture of low-molecular weight polymers having a degree of polymerization between 3 to 6.1 Compound 48/80 is a potent histamine releasing agent, primarily from mast cells, with a subsequent deple ...
... Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde; it is a mixture of low-molecular weight polymers having a degree of polymerization between 3 to 6.1 Compound 48/80 is a potent histamine releasing agent, primarily from mast cells, with a subsequent deple ...
Antimicrobials and Resistance
... - • Bacteriostatic (low doses) • Bactericidal (Higher doses) - Effective against: . Many G+, some G- bacteria . Chlamydia . Mycoplasma . T. pallidum . Legionella ...
... - • Bacteriostatic (low doses) • Bactericidal (Higher doses) - Effective against: . Many G+, some G- bacteria . Chlamydia . Mycoplasma . T. pallidum . Legionella ...
Metabolism of drugs
... • CYP 3A4/5 carry out biotransformation of largest number (30– 50%) of drugs. In addition to liver, this isoforms are expressed in intestine (responsible for first pass metabolism at this site) and kidney too • Inhibition of CYP 3A4 by erythromycin, clarithromycin, ketoconzole, itraconazole, verapam ...
... • CYP 3A4/5 carry out biotransformation of largest number (30– 50%) of drugs. In addition to liver, this isoforms are expressed in intestine (responsible for first pass metabolism at this site) and kidney too • Inhibition of CYP 3A4 by erythromycin, clarithromycin, ketoconzole, itraconazole, verapam ...
Thyroxine and Antithyroid Drugs(Hand out)
... When taken orally incorporated into thyroglobulin in a similar way to iodide The isotope used is 131I Emits both β and γ radiation. Β rays are destructive to tissues 131I has a half-life of 8 days∴its radioactivity lasts ∼2 months Cytotoxic effect on the gland is delayed for 1-2 months and maximum e ...
... When taken orally incorporated into thyroglobulin in a similar way to iodide The isotope used is 131I Emits both β and γ radiation. Β rays are destructive to tissues 131I has a half-life of 8 days∴its radioactivity lasts ∼2 months Cytotoxic effect on the gland is delayed for 1-2 months and maximum e ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
... circulation through the internal jugular vein which bypasses the drugs from hepatic first pass metabolism. [1] Pantoprazole sodium sesquihydrate (PSS) it is chemically known as sodium 5- (difluoromethoxy) - 2 – [[(3, 4-dimethoxy-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole sesquihydrate.[2] It ex ...
... circulation through the internal jugular vein which bypasses the drugs from hepatic first pass metabolism. [1] Pantoprazole sodium sesquihydrate (PSS) it is chemically known as sodium 5- (difluoromethoxy) - 2 – [[(3, 4-dimethoxy-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole sesquihydrate.[2] It ex ...
Prescrip on drugs - Rutgers Chemistry
... generic drug is chemically equivalent to Over-the-Counter the pioneer drug, but cannot be marketed until the patent protection on the pioneer drug has run out after 20 ...
... generic drug is chemically equivalent to Over-the-Counter the pioneer drug, but cannot be marketed until the patent protection on the pioneer drug has run out after 20 ...
anti tb drugs - PharmaStreet
... • Tuberculocidal for rapidly multiplying bacilli • Acts on extracellular as well as on intracellular TB • Equally active in acidic or alkaline pH • Cheapest anti-tubercular drugs ...
... • Tuberculocidal for rapidly multiplying bacilli • Acts on extracellular as well as on intracellular TB • Equally active in acidic or alkaline pH • Cheapest anti-tubercular drugs ...
PERIDOX PRESENTATION: Each Capsule contains: Doxycycline
... Atypical Pneumonia Infection, Acne, Lymphogranuloma venererum ...
... Atypical Pneumonia Infection, Acne, Lymphogranuloma venererum ...
proforma for registration of subjects for dissertation
... The fatty acid composition of total glycolipids6 and its components are determined by GLC showed linoleic acid, linolenic acid, oleic acid as the major fatty acids. Composition of glycolipids from five varieties namely C-429, R-552, RLC-, RLC-6 and T-397 of Vidharbha region was investigated with c ...
... The fatty acid composition of total glycolipids6 and its components are determined by GLC showed linoleic acid, linolenic acid, oleic acid as the major fatty acids. Composition of glycolipids from five varieties namely C-429, R-552, RLC-, RLC-6 and T-397 of Vidharbha region was investigated with c ...
镇静催眠药sedative-hypnotic drugs
... [Mechanism of action] The centrol role is related to the activation of GABAA receptors . Barbiturates can function as GABA in the absence of GABA , which can increase the permeability of Cl- channel , leading to the cell membrane hyperpolarization . Different from BZ drugs which increase Cl-chan ...
... [Mechanism of action] The centrol role is related to the activation of GABAA receptors . Barbiturates can function as GABA in the absence of GABA , which can increase the permeability of Cl- channel , leading to the cell membrane hyperpolarization . Different from BZ drugs which increase Cl-chan ...
Medications Requiring Prior Authorization for Medical
... There may be additional drugs subject to prior authorization or other plan design restrictions. Please consult your plan for further information. This list represents brand products in CAPS, branded generics in upper- and lowercase, and generic products in lowercase italics. This is not an all-incl ...
... There may be additional drugs subject to prior authorization or other plan design restrictions. Please consult your plan for further information. This list represents brand products in CAPS, branded generics in upper- and lowercase, and generic products in lowercase italics. This is not an all-incl ...
Drug Interactions Every Health Care Provider Should Know
... clopidogrel and a PPI reduces the antiplatelet effects of clopidogrel … It is not established that changes in these surrogate endpoints translate into clinically meaningful differences” ...
... clopidogrel and a PPI reduces the antiplatelet effects of clopidogrel … It is not established that changes in these surrogate endpoints translate into clinically meaningful differences” ...
2015 Preferred Drug List Exclusions
... 2015 Preferred Drug List Exclusions The excluded medications shown below are not covered on the Express Scripts drug list. In most cases, if you fill a prescription for one of these drugs, you will pay the full retail price. Take action to avoid paying full price. If you are currently using one of t ...
... 2015 Preferred Drug List Exclusions The excluded medications shown below are not covered on the Express Scripts drug list. In most cases, if you fill a prescription for one of these drugs, you will pay the full retail price. Take action to avoid paying full price. If you are currently using one of t ...
Analytical method development for pharmaceutical
... the amount of acid in the stomach, such as ketoconazole or digoxin. Generally inactive at acidic pH of stomach, thus it is usually given with a pro kinetic drug. MECHANISM OF ACTION:4 Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a ...
... the amount of acid in the stomach, such as ketoconazole or digoxin. Generally inactive at acidic pH of stomach, thus it is usually given with a pro kinetic drug. MECHANISM OF ACTION:4 Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a ...
Solubility # 6
... ⇒ A guide for the lipid solubility or the lipophilic nature of a drug is known as partition coefficient (p). ⇒ The partition coefficient, P, refers to the ratio of the concentrations of the drug in octanol to that in water. Octanol is used to mimic amphiphilic nature of lipid, because it has a prima ...
... ⇒ A guide for the lipid solubility or the lipophilic nature of a drug is known as partition coefficient (p). ⇒ The partition coefficient, P, refers to the ratio of the concentrations of the drug in octanol to that in water. Octanol is used to mimic amphiphilic nature of lipid, because it has a prima ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.