Pharmacologic Management of the Geriatric Patient
... activating factor (PAF) and adenosine = decreases platelet function (strongest sources of allicin is natural garlic clove) Ginkgo Uses: prevent decreased cerebral functions and peripheral vascular insufficiency associated with Alzheimer’s disease or age-related dementia Components implicated in blee ...
... activating factor (PAF) and adenosine = decreases platelet function (strongest sources of allicin is natural garlic clove) Ginkgo Uses: prevent decreased cerebral functions and peripheral vascular insufficiency associated with Alzheimer’s disease or age-related dementia Components implicated in blee ...
Anticoagulation Antidote Guide
... If ingested within 2 hours, administer activated charcoal For life threatening bleed or emergency surgery, consider idarucizumab (Praxbind) 5 gm IV (non-formulary drug at Harris/Swain) 65% removed by HD NOTES: Plasma dabigatran concentrations can increase more than 12-24 hours after administra ...
... If ingested within 2 hours, administer activated charcoal For life threatening bleed or emergency surgery, consider idarucizumab (Praxbind) 5 gm IV (non-formulary drug at Harris/Swain) 65% removed by HD NOTES: Plasma dabigatran concentrations can increase more than 12-24 hours after administra ...
Reducing the risk
... Promote safe practice for prescribers co-prescribing one or more clinically significant interacting medicines for patients already on oral anticoagulants - make arrangements for INR tests and inform monitoring clinic. Pharmacists to ensure precautions have been taken. Ensure that dental practitioner ...
... Promote safe practice for prescribers co-prescribing one or more clinically significant interacting medicines for patients already on oral anticoagulants - make arrangements for INR tests and inform monitoring clinic. Pharmacists to ensure precautions have been taken. Ensure that dental practitioner ...
Tropical fruit juices such as MonaVie, XanGo, Noni, Goji, and Pom
... Morinda is also known as "Noni" juice. It MIGHT be associated with a few cases of liver toxicity. Warn patients on ACEs, ARBs, and spironolactone that morinda is high in potassium...almost 15 mEq per 8 ounces. Goji contains sterols that prevent cholesterol absorption... but there's no proof that dri ...
... Morinda is also known as "Noni" juice. It MIGHT be associated with a few cases of liver toxicity. Warn patients on ACEs, ARBs, and spironolactone that morinda is high in potassium...almost 15 mEq per 8 ounces. Goji contains sterols that prevent cholesterol absorption... but there's no proof that dri ...
S0735109712013162_mmc1
... The ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), is similar to ABCA1 in location and function and a common variant (rs2231142) reduces its transport capacity (5). Carriers of the A allele experience higher systemic exposure to rosuvastatin{Keskitalo, 2009 #1376} or atorvastatin(6), ...
... The ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), is similar to ABCA1 in location and function and a common variant (rs2231142) reduces its transport capacity (5). Carriers of the A allele experience higher systemic exposure to rosuvastatin{Keskitalo, 2009 #1376} or atorvastatin(6), ...
PowerPoint Presentation - Anticoagulants and Thrombolytics
... Active in vitro and in vivo Administration - parenteral- Do not inject IM only IV or deep s.c. Half-life 1 - 5 hrs - monitor aPTT Adverse effect - hemorrhage - antidote protamine sulphate ...
... Active in vitro and in vivo Administration - parenteral- Do not inject IM only IV or deep s.c. Half-life 1 - 5 hrs - monitor aPTT Adverse effect - hemorrhage - antidote protamine sulphate ...
Heart Failure:
... many of the co-morbidities facing our elderly residents, this disease is also often misdiagnosed and not optimally treated. Parkinson’s is defined by having two of four specific symptoms: resting tremor, muscular rigidity, gait instability and bradykinesia. Parkinson’s Disease is caused by a deficie ...
... many of the co-morbidities facing our elderly residents, this disease is also often misdiagnosed and not optimally treated. Parkinson’s is defined by having two of four specific symptoms: resting tremor, muscular rigidity, gait instability and bradykinesia. Parkinson’s Disease is caused by a deficie ...
Drugs that increase the INR and risk of bleed Drugs that decrease
... be within 24 hours) and if the drug is withdrawn the effect disappears quickly depending on the drug half-life. The INR should if possible be monitored within 72 hours of starting the interacting drug and on withdrawal. • Drugs marked $ are liver enzyme inducers and decrease the INR. They act more s ...
... be within 24 hours) and if the drug is withdrawn the effect disappears quickly depending on the drug half-life. The INR should if possible be monitored within 72 hours of starting the interacting drug and on withdrawal. • Drugs marked $ are liver enzyme inducers and decrease the INR. They act more s ...
Chapter 48 Antidysrhythmic Drugs
... RECOMMENDATION: Health care professionals and institutions involved in performing spinal/epidural anesthesia or spinal punctures should determine, as part of a pre-procedure checklist, whether a patient is receiving anticoagulants and identify the appropriate timing of enoxaparin dosing in relation ...
... RECOMMENDATION: Health care professionals and institutions involved in performing spinal/epidural anesthesia or spinal punctures should determine, as part of a pre-procedure checklist, whether a patient is receiving anticoagulants and identify the appropriate timing of enoxaparin dosing in relation ...
Vitamin K Content in Common Foods
... II, VII, IX and X. As a result of vitamin K antagonism, warfarin inhibits the production of these four clotting factors. The oral formulation of warfarin is widely used for the long-term prevention of thromboembolic disease.13 Because vitamin K and warfarin are antagonists, the amount of vitamin K i ...
... II, VII, IX and X. As a result of vitamin K antagonism, warfarin inhibits the production of these four clotting factors. The oral formulation of warfarin is widely used for the long-term prevention of thromboembolic disease.13 Because vitamin K and warfarin are antagonists, the amount of vitamin K i ...
Atrial Fibrillation / Atrial Flutter Management Pathway (AF)
... Patients with mitral stenosis, prosthetic heart valves or risk score >1 usually require warfarin. Where antithrombotic therapy is given: The most effective treatment (reduces stroke risk by 2/3), is adjusted-dose Warfarin (target INR 2.5, range 2.0 to 3.0). USE WHOLE mg DOSES. Where Warfarin is ...
... Patients with mitral stenosis, prosthetic heart valves or risk score >1 usually require warfarin. Where antithrombotic therapy is given: The most effective treatment (reduces stroke risk by 2/3), is adjusted-dose Warfarin (target INR 2.5, range 2.0 to 3.0). USE WHOLE mg DOSES. Where Warfarin is ...
savaysa
... • Premature discontinuation of edoxaban increases the risk of ischemic events • Spinal/Epidural hematomas – Epidural or spinal hematomas may occur in patients treated with edoxaban who are receiving neuraxial anesthesia or ...
... • Premature discontinuation of edoxaban increases the risk of ischemic events • Spinal/Epidural hematomas – Epidural or spinal hematomas may occur in patients treated with edoxaban who are receiving neuraxial anesthesia or ...
Slide 1
... Dong quai, inhibits platelet function by natural coumarins (香豆素) & reduces thromboxine A2 synthesis by ferulic acid (阿魏酸) Dan shen, used to promote blood flow and treat CV diseases, contains coumarin, decrease elimination of warfarin, thus increases the risk of bleeding, platelet dysfunction ...
... Dong quai, inhibits platelet function by natural coumarins (香豆素) & reduces thromboxine A2 synthesis by ferulic acid (阿魏酸) Dan shen, used to promote blood flow and treat CV diseases, contains coumarin, decrease elimination of warfarin, thus increases the risk of bleeding, platelet dysfunction ...
Slide 1
... with right ileofemoral vein thrombosis. Enoxaparin was started and subsequently bridged to warfarin 5mg a day. After 1 week of warfarin therapy (9 days before her current hospitalization), her international normalized ratio (INR) was 2.5 One day prior to admission, she complained of bright red blood ...
... with right ileofemoral vein thrombosis. Enoxaparin was started and subsequently bridged to warfarin 5mg a day. After 1 week of warfarin therapy (9 days before her current hospitalization), her international normalized ratio (INR) was 2.5 One day prior to admission, she complained of bright red blood ...
DRUGS AFFECTING CLOT FORMATION
... known allergy to the drugs. - They also should not be used with any conditions ...
... known allergy to the drugs. - They also should not be used with any conditions ...
DRUGS TO TRY AND AVOID IN WARFARIN PATIENTS
... The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin. Patients already on any of these drugs may be started on warfarin and the dose adjusted as required. Drug interactions with warfarin tend to be variable and unpredictable and on t ...
... The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin. Patients already on any of these drugs may be started on warfarin and the dose adjusted as required. Drug interactions with warfarin tend to be variable and unpredictable and on t ...
Respiratory
... sick, they continue. An effective rodenticide must be tasteless and odorless in lethal concentrations, and have a delayed effect. ...
... sick, they continue. An effective rodenticide must be tasteless and odorless in lethal concentrations, and have a delayed effect. ...
Pharmacogenomics - LSU School of Medicine
... CYP2C9 variants take more time to achieve stable dosing, and are associated with increased risk of bleeding events. Low CYP2C9 activity results in higher plasma levels of warfarin so the patient is at risk for bleeding ...
... CYP2C9 variants take more time to achieve stable dosing, and are associated with increased risk of bleeding events. Low CYP2C9 activity results in higher plasma levels of warfarin so the patient is at risk for bleeding ...
Warfarin
Warfarin, also known by the brand names Coumadin among others, is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body, respectively. It was initially introduced in 1948 as a pesticide against rats and mice, and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s, warfarin was found to be effective and relatively safe for preventing thrombosis and thromboembolism in many disorders. It was approved for use as a medication in 1954, and has remained popular ever since. Warfarin is the most widely prescribed oral anticoagulant drug in North America.Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or ""greens,"" since these typically contain large amounts of vitamin K1) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. A high INR predisposes patients to an increased risk of bleeding, while an INR below the therapeutic target indicates the dose of warfarin is insufficient to protect against thromboembolic events.Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1. Thus, the pharmacologic action may always be reversed by fresh vitamin K1. When administered, these drugs do not anticoagulate blood immediately. Instead, onset of their effect requires about two to three days before remaining active clotting factors have had time to naturally disappear in metabolism, and the duration of action of a single dose of warfarin is 2 to 5 days. Reversal of warfarin's effect by discontinuing its use, or by administering vitamin K1, requires a similar period of time.Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant originally discovered in spoiled sweet clover-based animal feeds. Dicoumarol, in turn, is derived from coumarin, a sweet-smelling but coagulation-inactive chemical found naturally in ""sweet"" clover (to which it gives its odor and name), tonka beans (also known as ""cumaru"" from which coumarin's name derives), and many other plants. The name 'warfarin' stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization that funded the key research, ""WARF"" for the Wisconsin Alumni Research Foundation and the ending ""-arin"", indicating its link with coumarin.