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SAMPLE EXAM QUESTIONS
PATHOLOGY 300: HUMAN DISEASE
February, 2008
SECTION 1. Choose the correct answer:
1. Which of the following is NOT true about misfolded proteins:
1 they can be refolded by protein chaperones
2 they may be ubiquitinated and subsequently digested
3 they can accumulate within the cell and trigger apoptosis
4 they accumulate within neurons in some neurodegenerative diseases
5 they depress the synthesis of protein chaperones
Text, p 22
2. Coagulative necrosis is a characteristic feature seen in:
1 the brain following ischemic death of neurons
2 the heart following a myocardial infarct
3 the lung following a severe, but localized bacterial infection
4 the liver following excessive consumption of alcohol
5 the lung following infection with Mycobacterium tuberculosis
Text, p 10
3. Which of the following is NOT associated with free radical injury to cells:
1 lipid peroxidation in membranes
2 increased production of ATP in mitochondria
3 structural lesions in DNA
4 initiation of chain reactions that increase tissue damage
5 cross-linking of proteins
Text, p 17
SECTION 2. Choose the answer according to the following code:
Choose 1 if only A + C are correct
2 if only B + D are correct
3 if only A + B + C are correct
4 if only A + C + E are correct
5 if all are correct
4. Which of the following situations normally require the process of apoptosis:
A development of the human hand during embryogenesis
B atrophy of limb muscles during prolonged inactivity
C T cell killing of cells infected by viruses
D formation of a granuloma in the lung of a patient with tuberculosis
E continual turnover of epithelial cells in the skin and intestinal lining
Text, p 19
5. Which of the following are true about ischemic cell injury:
A mitochondrial production of ATP is markedly reduced
B activity of the Na-K pump in the plasma membrane is reduced
C the cell gains Na and water, and begins to swell
D glycolysis is elevated and lactic acid accumulates
E protein synthesis is reduced
Text, p18
6. Factors associated with Type 1 hypersensitivity include:
A increased production of IgE
B peripheral vasoconstriction
C reaction of antigen with bound IgE
D granuloma formation in response to antigen exposure
E release of prostaglandins and leukotrienes from mast cells
Text, p 121
7. During an inflammatory reaction, the quantity of exudate in the interstitium is related to:
A the osmotic pressure of the interstitial fluid
B the quantity of chemical mediators (histamine, bradykinin...) released
C the extent of injury to endothelial cells
D the number of regenerating capillaries in the area
E the hydrostatic pressure in the microcirculation
Text, p 34
SECTION 3: Decide if each statement in the pair is true or false
If they are both true, decide if the second is the cause of the first
Choose the correct answer according to the following code:
Choose 1 if True, True, causally related
2 if True, True, unrelated
3 if True, False
4 if False, True
5 if False, False
8. Hypertrophy is never observed in uterine smooth muscle
BECAUSE
Uterine smooth muscle can undergo hyperplasia in response to hormone stimulation
Text, p 3
9. The extent of a myocardial infarct can be estimated by quantifying plasma enzyme levels
BECAUSE
Necrotic cell death is accompanied by release of intracellular enzymes into the circulation
Text, p 18
10. Neurological abnormalities are common in patients with AIDS
BECAUSE
HIV selectively infects cortical neurons and triggers extensive neuronal lysis
Text, p 162
MIDTERM EXAM
Thursday, February 21,
7 - 8:30 pm
in
FIELDHOUSE AUDITORIUM (LEA 132)
Exam questions cover material from lectures 1-12 (Jan 3 - Feb 12).
BRING YOUR ID