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Course outline
Biology and Biotechnology Department
Cell Biology 10201321
2014/2015
Instructor: Dr Salwa Khalaf
Credit: lecture 3 hrs.
Text Book: Becker’s World of the Cell 8th edition (2012). Hardin, Bertoni and Kliensmith.
Course description: This course is concerned primarily with eukaryotic cells. Lectures are devoted to
structural details and the molecular functions of the different parts of the cell. Lectures will introduce
topics such as endocytosis, intramembrane transport, protein targeting, organelle biosynthesis, protein
sorting, exocytosis, cell shape, motility, and cell-to-cell interaction. In addition, lectures will deal with
signal transduction processes, cell cycle, mitosis, cancer and cellular functions that are required for cell
growth and programmed cell death. By its completion, students should have a comprehensive
understanding of the architecture and function of living cells.
Course Objective.
♦ Become familiar with the various sub-cellular structures and organelles inside eukaryotic cells
♦ Understand how proteins and lipids are synthesized, transported and degraded
♦ Learn about vesicular trafficking, endocytosis and exocytosis
♦ Gain an introduction to cellular signal transduction mechanisms (also known as cell signaling)
♦ Become familiar with the molecular structure and behaviors of the cytoskeleton
♦ Understand the basic events of the cell cycle and the importance of programmed cell death (apoptosis)
Learning outcomes.
At the end of this course, the student should be able to
 Describe the chemical components and processes of cells.
 Describe the storage of genetic information within cells and how this information is passed on to
the next generation.
 Discuss membrane structure and transport across cell membranes.
 Discuss the different macromolecules structures and functions.
 Describe the significant processes involved in transfer and storage of energy in a cell.
 Describe the significant processes that occur in cell communication and intracellular transport
 Describe the life cycle of cells and how these cycles are regulated.
 Describe the mechanisms involved in gene expression.
 Discuss the different possible causes of cancer, cellular changes at molecular level and the
different methods used and proposed for cancer therapy.
Class Schedule
Week Reading
material
1
Chapter 3
3
Chapter 7
4
Chapter 8
5
Chapter 9
5
Chapter 10
6
7
Chapter 12
Topic
Pages
The Macromolecules of the cell
Membranes: Their structure, function and chemistry
Transport across membranes: overcoming the permeability barrier
Chemotrophic energy metabolism: glycolysis and fermentation
Chemotrophic energy metabolism: aerobic respiration
First Exam
Endomembrane system and peroxisomes
41
156
194
224
252
324
8
8
9
10
Chapter 14
Signal transduction mechanisms II. Messengers and receptors
392
Chapter 15
Chapter 17
422
480
11
Chapter 18
12
13
14
15
16
Chapter 19
Chapter 23
Chapter 24
Cytoskeletal system
Beyond the cell: cell adhesion, cell junctions and extracellular
structures
Second Exam
The structural basis of cellular information: DNA, chromosomes and
nucleus
The cell cycle: DNA replication and mitosis
The regulation of gene expression
Cancer cells
505
549
758
Review and Final Exam
References:
1. The World of the Cell, 7th ed (2009), by Becker, Kleinsmith, Harden and Bertoni
2. Becker, Kleinsmith, and Hardin, 2006. The World of the Cell, 6th ed. Pearson Benjamin
Cummings.
3. Becker, Kleinsmith, and Hardin, 2004. The World of the Cell, 5th ed. Pearson Benjamin
Cummings.
4. Gerald Karp, 2008. Cell and molecular Biology; concepts and experiments, 5th ed. John Wiley and
sons.
5. Alberts et al, 2004. Essential Cell Biology, 2nd ed. Garland Science.
6. Pollard, T.D. and Earnshaw, W.C. 2002.Cell Biology, 1st ed. Elsevier Science (USA).
7. Lodish, H. et al. 2002. Molecular Cell Biology, 4th ed. New York: Freeman and Company.
8. Cooper,G. M., 2000. The Cell: A molecular approach. 2nd ed. Washington, D. C. ASM press.
Assessment and Evaluation
First Exam
25%
Second Exam 25%
Assignments
10%
Final Exam
40%
Total
100%