Download Gene Section FAD (Fanconi anaemia group D) Atlas of Genetics and Cytogenetics

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
Short Communication
FAD (Fanconi anaemia group D)
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Published in Atlas Database: April 1998
Online updated version: http://AtlasGeneticsOncology.org/Genes/FAD.html
DOI: 10.4267/2042/37433
This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence.
© 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Prognosis
Poor; mean survival is 16 years: patients die of bone
marrow failure (infections, haemorrhages), leukaemia,
or androgen therapy related liver tumours.
Cytogenetics
Spontaneous chromatid/chromosome breaks; increased
rate of breaks compared to control, when induced by
breaking agent.
Identity
Other
names:
FACD
(Fanconi
complementation group D)
Location: 3p24.2
Local order: not far to XPC, in 3p25.
anaemia
References
Whitney M, Thayer M, Reifsteck C, Olson S, Smith L, Jakobs
PM, Leach R, Naylor S, Joenje H, Grompe M. Microcell
mediated chromosome transfer maps the Fanconi anaemia
group D gene to chromosome 3p. Nat Genet 1995;11(3):341-3.
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular
Cytogenetics.
DNA/RNA
Description
D'Andrea AD, Grompe M. Molecular biology of Fanconi
anemia: implications for diagnosis and therapy. Blood
1997;90(5):1725-36.
Yet unknown; only localized.
This article should be referenced as such:
Implicated in
Huret JL. FAD (Fanconi anaemia group D). Atlas Genet
Cytogenet Oncol Haematol.1998;2(3):83.
Fanconi anaemia; FA1 is implicated in
the FA complementation group D
Disease
Fanconi anaemia is a chromosome instability
syndrome/cancer prone disease (at risk of leukaemia).
Atlas Genet Cytogenet Oncol Haematol. 1998;2(3)
83