Download Gene Section GLTSCR2 (glioma tumor suppressor candidate region gene 2)

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Gene Section
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GLTSCR2 (glioma tumor suppressor candidate
region gene 2)
Tomohiko Maehama
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo
162-8640, Japan (TM)
Published in Atlas Database: October 2008
Online updated version : http://AtlasGeneticsOncology.org/Genes/GLTSCR2ID40723ch19q13.html
DOI: 10.4267/2042/44552
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2009 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Homology
Identity
GLTSCR2 orthologs can be found in metazoans. In
addition, GLTSCR2 protein shares homology with
yeast Nop53p which is involved in ribosome
biogenesis.
Other names: PICT-1, PICT1, p60
HGNC (Hugo): GLTSCR2
Location: 19q13.32
Local order: Between D19S1160 and D19S1156.
Mutations
DNA/RNA
Note
There are several synonymous and nonsynonymous
SNPs reported for GLTSCR2 (S16R, Q169E, C325F,
A383V, Q389R).
Description
The GLTSCR2 gene comprises 13 exons resulting in a
transcript of 1567 bases. The start codon is in the 1st
exon; the stop codon is in the 13th exon. Northern blot
analysis shows a 1.5-kb transcript.
Implicated in
Transcription
Cancer
mRNA: ubiquitously.
Note
A number of groups have proven that the 19q13.32
locus where GLTSCR2 gene locates is frequently
altered in glioma and neuroblastoma; however, a tumor
suppressor gene(s) specifically encoded in this region
has yet to be identified and the implication of
GLTSCR2 gene in these tumors remains controversial.
Recent studies show aberrations in GLTSCR2
expression in glioblastoma and neuroblastoma.
Pseudogene
Not known.
Protein
Description
478 amino acids. GLTSCR2 protein contains a putative
PEST sequence (PEST score: +7.23, aa: 279-332) and a
potential nuclear localization signal (aa: 378-386).
References
Localisation
Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U,
Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser
HW, Louis DN, Jenkins RB. A transcript map of the
chromosome 19q-arm glioma tumor suppressor region.
Genomics. 2000 Feb 15;64(1):44-50
Nucleolus.
Function
GLTSCR2 protein binds to PTEN tumor suppressor
and regulates its stability in cells. Recent reports show
the implication of GLTSCR2 in cell proliferation and
apoptosis.
Atlas Genet Cytogenet Oncol Haematol. 2009; 13(9)
Mora J, Cheung NK, Chen L, Qin J, Gerald W. Loss of
heterozygosity at 19q13.3 is associated with locally aggressive
neuroblastoma. Clin Cancer Res. 2001 May;7(5):1358-61
624
GLTSCR2 (glioma tumor suppressor candidate region gene 2)
Maehama T
Hartmann C, Johnk L, Kitange G, Wu Y, Ashworth LK, Jenkins
RB, Louis DN. Transcript map of the 3.7-Mb D19S112D19S246 candidate tumor suppressor region on the long arm
of chromosome 19. Cancer Res. 2002 Jul 15;62(14):4100-8
Yim JH, Kim YJ, Cho YE, Ko JH, Kim SM, Kim JY, Park JH.
GLTSCR2 sensitizes cells to hypoxic injury without
involvement
of
mitochondrial
apoptotic
cascades.
Pathobiology. 2007;74(5):301-8
Maehama T, Okahara F, Kanaho Y. The tumour suppressor
PTEN: involvement of a tumour suppressor candidate protein
in PTEN turnover. Biochem Soc Trans. 2004 Apr;32(Pt 2):3437
Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park
JH. The putative tumor suppressor gene GLTSCR2 induces
PTEN-modulated cell death. Cell Death Differ. 2007
Nov;14(11):1872-9
Okahara F, Ikawa H, Kanaho Y, Maehama T. Regulation of
PTEN phosphorylation and stability by a tumor suppressor
candidate protein. J Biol Chem. 2004 Oct 29;279(44):45300-3
Kim YJ, Cho YE, Kim YW, Kim JY, Lee S, Park JH.
Suppression of putative tumour suppressor gene GLTSCR2
expression in human glioblastomas. J Pathol. 2008
Oct;216(2):218-24
Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y,
Maehama T. Critical role of PICT-1, a tumor suppressor
candidate, in phosphatidylinositol 3,4,5-trisphosphate signals
and tumorigenic transformation. Mol Biol Cell. 2006
Nov;17(11):4888-95
This article should be referenced as such:
Maehama T. GLTSCR2 (glioma tumor suppressor candidate
region gene 2). Atlas Genet Cytogenet Oncol Haematol. 2009;
13(9):624-625.
Ji D, Deeds SL, Weinstein EJ. A screen of shRNAs targeting
tumor suppressor genes to identify factors involved in A549
paclitaxel sensitivity. Oncol Rep. 2007 Dec;18(6):1499-505
Atlas Genet Cytogenet Oncol Haematol. 2009; 13(9)
625