Download LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOMED.INSTRUMENTATION SC.
FOURTH SEMESTER – APRIL 2010
BI 4954 - BIOMEDICAL INFORMATICS
Date & Time: 22/04/2010 / 9:00 - 12:00 Dept. No.
Max. : 100 Marks
PART-A
Answer ALL the questions
10x2=20 Marks
1. Comment on BLAST
2. Define ORF. What is the online software tool available to identify ORF?
3. Define Cheminformatics.
4. Comment on SOPMA?
5. Give the significance of Gap penalties.
6. List out the search engines for biological information.
7. What are web browsers? Give two examples.
8. Enumerate the activities of EMB net.
9. Comment on dendrogram.
10. Write a note on OMIM
PART-B
Answer any FOUR of the following
4x10=40 Marks
11. Describe the dot plot method for comparison of two sequences.
12. Explain Blast and types of blasts.
13. Give a detail account of FASTA.
14. Write notes on DNA sequence databases.
15. Describe Multiple Sequence Alignment and its significance.
16. Give an account on information resources.
PART-C
Answer any TWO of the following
2x20=40 Marks
17. Describe the Needleman and Wunsch and Smith - Waterman algorithm.
18. Explain in detail Structure and classification of proteins.
19. Describe the various ways to identify lead compound? Describe the steps involved in the
development of a new drug.
20. Discuss the available biological databases for proteins.
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