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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 B.Sc. DEGREE EXAMINATION – MATHS & PHYSICS THIRD SEMESTER – APRIL 2014 AZ 3202 - BIOINFORMATICS - THEORY Date : 10/04/2014 Time : 09:00-12:00 Answer ALL the questions Dept. No. Max. : 100 Marks Part-A (10×2=20 Marks) 1. What are the broad areas of Bioinformatics ? 2. How do you depict a palindrome sequence ? 3. Write the principle involved in microarray. 4. Write the application of Rasmol ? 5. Comment on AUTODOCK. 6. State BLAST algorithm. 7. Define homology modelling. 8. Distinguish alpha helix from beta pleat. 9. Mention any two network topology. 10.Expand: a) DDBJ c) PDB. Answer any FOUR questions Part-B (4×10=40 Marks) 11. Enumerate the applications of Human Genome Project. 12. 13. 14. 15. 16. Write about the multiple sequence alignment. What are public domain data bases ? Write the data bases using respective tools. How do you compile and run a C-program ? What are the scope of Bioinformatics ? Write the procedure to sequence DNA. Part-C Answer any TWO questions (2×20=40 Marks) 17. Discuss the applications of Bioinformatics. 18. Elucidate the pharmacogenomic perspective of drug designing. 19. How to predict protein structures using proteomic tools ? 20. What are the tools being used in Genetic Engineering ? ************