Download Introductory Molecular and Cell Biology (Shors, Kostman)

BIO 323: Introductory Molecular and Cell Biology
Spring Semester 2006
Lecturers:
Dr. Teri Shors, HS 155 [email protected]
Dr. Todd Kostman, HS 156 [email protected]
Office hours:
Dr. Teri Shors: Mondays 10:20-12:20 pm Fridays 1:50-2:50 pm.
Dr. Todd Kostman: M,W 10:30-12:30.
Lecture Hours: 9:10-10:10 am, Halsey 175
Textbook:
Cell and Molecular Biology, 4th Edition by Gerald D. Karp
Class NOTES/Attencance Policy: There are many details to learn regarding the molecular
biology of cells and cellular processes. For this reason, to help focus students on the most
important material, instructors will provide notes in the form of a powerpoint presentation
(available via D2L) ONLY IF class ATTENDANCE IS 90% IN THE CLASS. If attendance drops
below 90%, notes will no longer be provided.
Introductory Molecular and Cell Biology and Promoting the Liberal Arts: A liberal arts
education refers to studies in a college or university intended to provide general knowledge and
develop intellectual capacities. A liberal arts education prepares students to work in a variety of
jobs. This is different from other types of education where students develop professional or
vocational skills for a specific job. The Biology, Microbiology and Medical Technology Majors are
offered at UW-Oshkosh within the College of Letters and Science (COLS). The COLS emphasizes
a liberal arts education. It promotes a liberal arts education model proposed by Carol Geary
Schneider, president of the Association of American Colleges and Universities since 1998.
Schneider stresses the idea that ALL students receive an education of lasting value, relevant
for the 21st century. In her model learning should be: 1) "analytical, contextual and holistic
thinking;" 2) "effective communication using multiple illiteracies and forms of expression;" 3)
"critical reflection/informed action as citizens, producers, human beings;" 4) "ethical action for
local and global communities;" and 5) "integrative learning."
At UW-Oshkosh, you will have a broad exposure to the liberal arts, while focusing on a topic that
you are particularly interested in such as a biology or microbiology. BIO 323 (Introductory
Molecular and Cellular Biology) is core course within all three of the aforementioned majors. The
unifying theme in this course is the oneness of all earthly life forms, attesting to their common
evolutionary origin. As described in the COLS's learning objectives, in addition to studying the
factual content of the science, we will also consider its historical development, experimental basis,
and relationship to other aspects of science and society.
Cell Phones: Please turn off cells phones during the lecture or exams of this course as a
common courtesy.
Grading: Your grade will be based upon your performance on four lecture exams (100 pts. each)
and five quizzes that will be given (at random times) during the cell part of the course. Grading
Scale: 92-100%=A, 89-91%=AB, 82-88%=B, 79-81%=B/C, 72-78%=C, 68-71%=C/D, 60-67%=D,
below 60%=F. Your grade will be calculated by dividing the total number of points you earn over
the semester by the total number of points possible (450).
Make Up Exams: If you will not be able to attend an exam, it is your responsibility to contact Dr.
Shors or Dr. Kostman before the scheduled exam time. Make-up exams will only be given to
students suffering from a life-threatening illness and having a written medical excuse to
support that claim.
Academic conduct: You are expected to conduct yourselves in an honorable fashion. Any act of
cheating will be dealt with according to the UW Oshkosh Student Discipline Code. Cheating may
result in an F in the course and expulsion from the University.
Tentative Schedule:
Date:
Mon. Jan. 30
Fri. Mar. 3
Topic
Syllabus, Pre-Quiz Introduction
Howard Hughes Holiday Lecturers Scientist Clips
Film: Sequencing Life (16 minutes)
Ch. 12: The Cell Nucleus and the Control of Gene Expression
Film: Understanding the Power of Genes
Ch. 12: The Cell Nucleus and the Control of Gene Expression
Ch. 10: The Nature of the Gene and the Genome
Ch. 10: The Nature of the Gene and the Genome
NOVA: Secret of Photo 51
Chapter 13: DNA Replication and Repair
Chapter 13: DNA Replication and Repair
EXAM 1
Film: Hopeful Monsters: Evolution and Genetics
Chapter 11: Expression of Genetic Material: From
Transcription to Translation
Chapter 11: Expression of Genetic Material: From
Transcription to Translation
Chapter 11: Expression of Genetic Material: From
Transcription to Translation
NOVA: Cancer Warrior
Mon. Mar. 6
Wed. Mar. 8
NOVA: Brain Eaters
Ch. 12: The Cell Nucleus and the Control of Gene Expression
Fri. Mar. 10
Ch. 12: The Cell Nucleus and the Control of Gene Expression
Wed. Feb. 1
Fri. Feb. 3
Mon. Feb. 6
Wed. Feb. 8
Fri. Feb. 10
Mon. Feb. 13
Wed. Feb. 15
Fri. Feb. 17
Mon. Feb. 20
Wed. Feb. 22
Fri. Feb. 24
Mon. Feb. 27
Wed. Mar. 1
Mon. Mar. 20
Wed. Mar. 22
Fri. Mar. 24
Mon. Mar. 27
Wed. Mar.29
Fri. March 31
Mon. Apr. 3
Wed. Apr. 5
Fri. Apr. 7
Mon. Apr. 10
Wed. Apr. 12
Fri. Apr. 14
Mon. Apr. 17
Wed. Apr. 19
Spring Break March 13-17
Film: The Secret Life of the Brain: The Teenage Brain
Review
EXAM 2
Introduction: What is a Cell? Prokaryotic vs. Eukaryotic Cells
Basic Chemistry
Molecules
Membranes I: membrane function and plasma membrane
structure
Membranes II: Membrane proteins and fluidity
Membranes III: Transport and nerve impulse transmission
Endomembrane system
ER, Golgi, and vesicular transport
Lysosomes, endocytosis and post-translational uptake
Cytoskeleton, microtubules
Review for Exam 3
Fri. Apr. 21
EXAM 3 (Chapters 1,2,4, 8 and 9)
Mon. Apr. 24
Intermediate and Microfilaments
Wed. Apr. 26
Muscle contraction and non-muscle motility
Fri. Apr. 28
Cell signaling
Mon. May 1
G-protein and protein tyrosine mechanisms
Wed. May 3
Calcium, convergence and cross-talk
Fri. May 5
Programmed cell death
Mon. May 8
Genetics of cancer
Wed. May 10
Wrap-up and review for Exam 4
Fri. May 12
EXAM 4
The instructors reserve the right to modify this syllabus during the semester
Chapter
pp. 492-516.
pp. 492-516
Chapter 12
Chapter 10
Chapter 10
Chapter 13
Chapter 13
Chapter 11
Chapter 11
Chapter 11
Chapter 12
pp. 516-548
Chapter 12
pp. 516-548
1.1-1.3
2.4-2.5
2.5-2.6
4.1-4.3
4.4-4.6
4.7-4.8
8.1-8.3
8.3-8.5
8.6, 8.8-8.9
9.1-9.3
9.4-9.5
9.6-9.7
15.1-15.2
15.3-15.4
15.5-15.6
15.7-15.8
16.1-16.3