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Mini-Toober Beta-Globin Folding
©
Kit©
Teaching Points
Proteins become real in your students’ hands as they fold 3 Mini-Toober β-globin
fragments and discover primary, secondary and tertiary structure in this model. Maps
guide students in marking the levels of structure onto 3 Mini-Toober fragments before
folding each into its 3D shape. These three fragments are then assembled to form the
completed structure. Connectors simulating hydrogen bonds help to stabilize the
structure, and selected sidechains are added to demonstrate salt bridges, heme
binding, and the site of the mutation leading to sickle cell anemia. Oxygen binding at
the heme group can also be demonstrated with the completed model.
Models in this Collection
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2 Mini-Toober β-Globin Folding Kits©
Model Details
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Each Mini-Toober β-Globin Folding Kit contains:
o 3 Mini-Toobers (blue, green, red)
o 3 Mini-Toober β-Globin Folding Maps (blue, green, red)
o 4 Zip bags with parts for each Mini-Toober (blue, green, red and yellow*)
Sidechains
Heme Group and Heme Connectors
Metal Clips
Markers
Support Posts
Colored Dots
Iron atom
Oxygen atom
o 3 Laminated Amino Acid Sidechain Lists
o 3 Wooden Dowels
o 1 CD
Teacher Notes
Blue Segment – Intro and Directions
Green Segment – Intro and Directions
Red Segment – Intro and Directions
Jmol images of folded segments
Documentation included
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Teaching points and inventory
How do the models fit in the suitcase?
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