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iGEM 2010: Idea Brainstorm Alejandro Virrueta Topics/Problems • Create a standardized vesicular transport system. Uses: gene therapy studies, cellular transport studies, etc. • Long-distance signaling. Uses: Detection/radar, population dynamics, etc. Mechanisms: Vesicular Transport • Choose a peptide sequence, which serves as an address. Fuse it to a protein sequence in DNA format. Insert plasmid into cell, express protein plus tag, protein directs to appropriate location. • Might expand to intercellular systems. • Standardize to facilitate targeting process. Mechanisms: Long-Distance Communication • Idea 1) Add a chemical inducer. One cell population secretes protein 1, other population produces protein 2. These two proteins associate to form protein 3. Bacteria sense protein 3 and swim towards it. Mechanisms: Long-Distance Communication • Idea 2) Form a neuronal circuit to transmit an electromagnetic wave. Might consist of 4 neurons, oriented anti-parallel to each other. Program in such a way as to control firing frequency to concentration of chemical inducer. Mechanisms: Long-Distance Communication • Idea 3) Fluorescence emission and detection. A population of cells produces of a luminescent protein in vesicles, while another population of cells forms rows of light sensitive chemicals. Activation leads to directed motility. • Might be modified for specific wavelength recognition, or behavioral pattern. Other Ideas • Modify cells to serve as electrical conduits for use in materials integration, i.e. neural prosthetics, brainmachine interfaces, etc.