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Cell Cycle Interphase • Cell normally functioning • Phase cell is in most of the time • G1, G0, S, G2 Mitosis-PMAT • • • • Prophase-Prepare Metaphase-Middle Anaphase-Apart Telophase-THE END Prophase-PREPARE • • • • • Cell PREPARES to divide Centrioles get into place Spindle fibers form Chromosomes condense Nuclear envelope dissolves Metaphase-MIDDLE • Chromosomes line up in the MIDDLE of the cell Anaphase-APART • Chromosomes are pulled APART by the centrioles and spindle fibers Telophase-THE END • The chromosomes are at each end of the cell and nuclear envelops form • The cell divides in two-Cytokinesis • THE END What does PMAT stand for? Prophase Metaphase Anaphase Telophase Prepare Middle Apart THE END Mitosis Controls on Cell Division • Cells only divide when growth is needed • Cyclins and Cyclin Dependent Kinases (CDK) are proteins that regulate the timing of the cell cycle Uncontrolled Cell Growth • When cells lose the ability to control growth it results in a mass of cells called a tumor. • Benign tumors – Do not metastasize (spread) • Malignant tumors-Cancer – Metastasize Skin Cancer Lung Cancer Cancer