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Mutagenesis and Genetic Screens What is a mutation? What are the types of mutations? Consequences of point mutations Types of chromosome mutations What are the consequences of mutations? Consequences of point mutations within genes Figure 15-2 Sequence of the b-globin Gene Point mutations can alter mRNA splicing Consequences of point mutations on gene products How do mutations occur? Bases may take on rare tautomeric forms prone to mismatch Bases may take on rare tautomeric forms prone to mismatch Figure 15-8b Tautomeric shifts in DNA bases may cause mutations Indel mutations result in frameshifts Alternative pairings for 5-bromouracil (5-BU) Alternative pairings for 2-aminopurine Alkylation-induced specific mispairings Figure 15-16 Intercalating agents Figure 15-17a Intercalating agents Figure 15-17b UV-light-generated photoproducts Figure 15-18 Trinucleotide repeats in the FMR-1 gene hinder transcription Slipped mispairing causes repeat expansion Figure 15-13