Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Fig. 2 Genetic alterations and the progression of colorectal
Document related concepts
no text concepts found
Transcript
Cancer Genome Landscapes by Bert Vogelstein, Nickolas Papadopoulos, Victor E. Velculescu, Shibin Zhou, Luis A. Diaz, and Kenneth W. Kinzler Science Volume 339(6127):1546-1558 March 29, 2013 Published by AAAS Fig. 1 Number of somatic mutations in representative human cancers, detected by genome-wide sequencing studies. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 2 Genetic alterations and the progression of colorectal cancer. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 3 Total alterations affecting protein-coding genes in selected tumors. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 4 Distribution of mutations in two oncogenes (PIK3CA and IDH1) and two tumor suppressor genes (RB1 and VHL). Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 5 Number and distribution of driver gene mutations in five tumor types. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 6 Four types of genetic heterogeneity in tumors, illustrated by a primary tumor in the pancreas and its metastatic lesions in the liver. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 7 Cancer cell signaling pathways and the cellular processes they regulate. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 8 Signal transduction pathways affected by mutations in human cancer. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS
